Figura 1 Estructura pared celular fngica(1)

Figura 2 Mecanismo inmunoestimulantes de -glucanos fngicos(2)

Figura 3 Terpenoides de Ganoderma lucidum(3)
Tabla 1 Algunos poliscridos inmunomoduladores aislados de macromicetos(4)
Compuesto bioactivo Fuente Beneficios
Heteroglucanos y homoglucanos Agaricus blazei, Anticancergeno y antitumoral
Ganoderma lucidum,
Lentinus edodes,
Grifola frondosa,
Coriolus versicolor,
Schizophyllum
commune

-(1,3)-glucano con ramificaciones -(1,6),-(1,2)- Agaricus blazei, Inmunomoduladores. Efecto del -

manano ramificado en -(1,3), -(1,3)-glucano, Cordyceps sinensis, glucan asociado con la activacin de
cordiglucano, lentinan, glucano, manoglucano, Cryptoporus volvatus, macrfagos, clulas T y NK.
galactomanano, grifolano, esquizofilano, poliscridos Ganoderma lucidum, Activacin y diferenciacin de los
cidos, heterogalactano, krestin, heteroglicano, Grifola frondosa, linfocitos T.
escleroglucano (-(1,3)- glucano ramificado -(1,6)- Hericium erinaceus,
monoglucosil), heteroglucanos Inonotus obliquus,
Lentinus edodes,
Morchella esculenta,
Phellinus linteus,
Pleurotus ostreatus,
Polystictus versicolor,
Schizophyllum
commune, Sclerotinia
sclerotiorum, Tremella
aurantialba

-glucanos y exopolysacridos Agaricus blazei, Efecto antidiabtico

Cordyceps sinensis,
 Lentinus edodes,
Phellinus baumii,
Tremella fuciformis

Tabla 2 Algunas Protenas Inmunomoduladoras Fngicas (FIPs)(3)

Name Producer
Immunomodulatory effect Refs
of FIP organism
Induction of mRNA expression of different cytokines (IL-
FIP- Antrodia
1b, IL-6, IL-12, TNF-a) and chemokines (CCL3, CCL4, CCL5, [28]
aca camphorate
CCL10)
Stimulation of mitogenesis in human peripheral
Flammulina
FIP-fve lymphocytes, suppression of systemic anaphylaxis reaction, [22]
velutipes
enhanced transcription of IL-3, INF-g
Ganoderma
FIP-glu Enhanced transcription of IL-2, IL-3, IL-4, IFN-g, TNF-a [23]
lucidum
FIP- Ganoderma
Down regulation of TNF-a [29]
gmi microsporum
Induction of cytokine secretion, cellular proliferation of
Ganoderma
FIP-gts human peripheral mononuclear cells (HPBMCs), enhanced [24]
tsugae
IFN-g expression
Ganoderma
FIP-gsi Enhanced production of IL-2, IL-3, IL-4, INF-g, TNF-a [25]
sinensis
FIP-
Poria cocos Enhanced production of IL-1b, IL-6, IL-18, TNF-a, NO [26]
pcp
FIP- Trametes Increased human peripheral blood lymphocytes, enhanced
[30]
tve versicolor production of TNF-a, NO
FIP- Volvariella
Enhanced expression of IL-2, IL-4, IFN-g, TNF-a [27]
vvo volvacea
Abbreviation: CCL, chemokine CC ligand.

Figura 4 Alineamiento mltiple de FIPs aislados de macromicetos(4)

Figura 5 Estrucutura primaria y secundaria de f Fip-gts(4)

1. Snchez J, Montoya S, Vargas LM. Polysaccharide production by submerged

fermentation. Polysaccharides Bioactivity Biotechnol. Springer; 2015;451-73.
2. Giavasis I. Bioactive fungal polysaccharides as potential functional ingredients in food
and nutraceuticals. Curr Opin Biotechnol. Elsevier; 2014;26:162-73.
3. El Enshasy HA, Hatti-Kaul R. Mushroom immunomodulators: unique molecules with
 unlimited applications. Trends Biotechnol. Elsevier; 2013;31(12):668-77.
4. Moradali M-F, Mostafavi H, Ghods S, Hedjaroude G-A. Immunomodulating and
anticancer agents in the realm of macromycetes fungi (macrofungi). Int
Immunopharmacol. Elsevier; 2007;7(6):701-24.