Continuous Single Pot Fluid Bed Granulation Granulator & Fluid Bed granulation process Dryer + High containment + One-pot operation + Established technology + Small footprint and + One-pot operation + Limited number of + Very high throughput height requirement + Small footprint operators + Granulation process can (especially if directly + Granulation process can + Small footprint compensate fluctuations in integrated with tablet compensate fluctuations in + Possibility of additional raw material specification press) raw material specification unit operations + Possibility of additional + Minimal need of + Very fast changeover + Excellent compression unit operations operators + Easy and safe handling of behaviour of granules + Granulation process organic solvents produced can compensate + High Yield + Easy scale up fluctuations in raw + Limited need of operators material specification + Distinctive solution for + Fast changeover effervescent production + No process scale-up (time is the only relevant factor) + High Yield
- Limited throughput - Handling of organic - Limitation in yield - No possibility for
- No possibility for solvents - Large footprint additional unit additional unit operations - Height requirement - Large height operations - Scale up - Handling of organic - Long time for changeover - No possibility to solvents is more complex - Large number of work in gram scale operators - Handling of organic - Handling of organic solvents requires solvents requires complex complex setup set- up - Difficult scale up