Functional Diagnostic Nutrition

EPP & UMP

Presenters:
Reed Davis & Michael McEvoy
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 People Want To Know
1. Do you know whats wrong with me?
Yes - malfunctions and dis-ease
all they do is treat symptoms
we are Health Detectives
2. Can you help me?
Yes lab work and FDN protocols
we identify healing opportunities
help restore normal function
3. Have you helped others like me?
Yes - 1000s have been helped!
FDN Family is growing strong welcome!

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People come to us with many
common health complaints
Allergies, acne, and rosacea
Blood sugar problems
Depression and anxiety, emotional fragility
Headaches and fogginess
Indigestion and bloating
Inflammation, pain, asthma, allergies
Insomnia and wakefulness
Low sex drive, PMS
Hypertension, cholesterol problems
Fatigue and lethargy
Weight gain and weight loss
Other Chronic Stress Related Disorders

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My Doctor Says Everything Looks Normal

many malfunctions are

overlooked by the medical model
Because bloodwork looks normal
doesnt mean its all in your head
Symptoms are not the problem, they
are the results of the problem

Headaches are not the result

of an aspirin deficiency
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 Rather than treat symptoms, the FDN model
focuses on investigating/handling causal factors
Adrenal related dysfunction
Circadian rhythm problems
Poor nutrient breakdown and absorption
Pro-oxidant and anti-oxidant imbalances
Dysbiosis and gut malfunction
Hormone dynamics
Inflammatory state, Immunodeficiency
Sluggish liver, detoxification problems
Bacterial and yeast overgrowth
Antigenic overload and pathogenic conditions
Environmental pollutants, toxicity, metals
And acting upon those healing
opportunities instead of treating the
symptoms

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 Heres How I Work
Functional lab testing to identify malfunctions
and healing opportunities within the
Hormone
Immune
Digestion
Detoxification
Environmental
Neurotransmitter
H.I.D.D.E.N stressors and
dysfunctions at the root of
most health complaints

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Lifestyle based protocols and potent, proven,
professional botanical/bio-identical products
Drugless protocols & behavior requirements
supporting bodys innate healing ability and
Diet
Rest
Exercise
Stress Reduction
Supplements
D.R.E.S.S. for Health
Success

Copyright 2008 - 13 Functional Diagnostic Nutrition

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We offer healing opportunities more
than assurances of outcomes

Process of probing and analyzing

and continuous course correction
until the body heals and normal
function/health returns
commitment
consistency
follow-through
follow-up
honest feedback
willingness to learn
possible retesting

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 Not a Medical Approach
Do not diagnose or treat disease
Seek out and act on the healing opportunities
medical treatment is for specific diseases or
diagnosis
FDN works in a non-specific manner on rebuilding
health, restoring function and cleaning up
inflammation and toxicity
medical treatment depends on drugs and surgery
FDN depends on lifestyle modifications, natural
therapies included in the DRESS for Health
Success system

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 Distress?
or
Eustress?

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Copyright 2008 - 12 Functional Diagnostic Nutrition
Stress is any influence, internal or external, that
causes or leads to malfunction ~ Reed Davis

Mental/Emotional
Fear
Worry
Excitement
Anxiety
Relationship
Existential Angst
Lack of purpose
Covertness
Negative perceptions
Bad attitude

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Physical trauma accumulates over time and can
manifest at any time, any place Reed Davis

Physical/Biomechanical
Trauma, micro-trauma
Fractures
Muscle injuries, weakness
Nerve compression
Repetitive, positional injury
Intense, prolonged exercise
Poor posture
Accidents

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Stress is often well hidden and may involve
several layers of investigation Reed Davis

Chemical/Biochemical/Functional
Inflammatory foods, additives
Pesticides, herbicides, GMOs
Alcohol, caffeine, blood sugar
Prescription, Recreational drugs
Environmental toxins, pollutants
Radiation, EMFs
Chemicals, metals, plastics
Anti-biotics, OTC meds
Exogenous hormones (BC)
Parasites, bacteria, fungi, viruses
Sleep deprivation, no exercise
Allergies, over-active immune

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The Stress Cascade is invariably in play ~

Stress related interferences

and imbalances in one area

if not soon resolved

cascade into other areas

causing serious malfunctions

leading to dis-ease
and symptoms

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Symptoms may be very far removed from
their causal factors or stressors ~ Reed
Adrenal, Circadian rhythm issues
Poor nutrient breakdown and absorption
Pro-oxidant and anti-oxidant imbalances
Environmental toxins, pollutants
Radiation, EMFs
Chemicals, metals, plastics
Dysbiosis and gut malfunction
Hormone dynamics
Inflammatory state, immunodeficiency
Sluggish liver, detoxification problems
Bacteria and yeast overgrowth
Neurochemistry, neurotoxin problem
Acting on healing opportunities rather than
treating symptoms leads to better health - Reed
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 FDN Functional Assessments
(Biochemical/Physiological Level)

Hormone/Immune System
BH205 Adrenal Stress Profile, Plus V (saliva)
Digestion/Detoxification/Immunity
BH101 Metabolic Assessment Profile (urine)
BH304 Intestinal Barrier Function (saliva)
Antigenic/Pathogenic/Inflammatory
BH401H GI Pathogen (stool)
Signet Mediator Release Test (blood)
Medical Director Program/FDN Masters
Multiple labs available for advanced investigation into
hidden stressors and dysfunction
Always seeking new/deeper healing opportunities
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US BioTek Environmental Pollutants (EPP) &
Urinary Metabolic Profile (UMP)

Michael McEvoy FDN, CNC, CMTA

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 EPs: Unprecedented Level of
Environmental Chemical Toxicity

Over 80 K chemicals introduced into the environment

Few tested for safety and toxicity to humans
Studies demonstrate harmful effects on DNA, brain,
blood, nervous, endocrine systems
Effect of multiple chemical exposures not known.
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 Infants, Children & Expectant Mothers

In a study published by
the Environmental
Working Group
(www.ewg.org), entitled
Body Burden II, the cord
blood of the average
baby at birth contains 200
chemicals.

Phthalates, xylene, toluene, benzene, styrene, and

dimethylbenzene are all developmentally toxic.
Mark Schauss

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 Common Chemical Sources (short list)

In Your Home: Childrens pajamas & toys, mattresses, bedding

& carpeting, PVC flooring, pool covers, cigarette smoke
That new car smell
Cosmetics: hair dyes, lipstick, eyeliner, shampoos, detergents,
skin creams, perfumes, hair gels, antiperspirants, shaving gels,
baby lotions
In Your Food: Packaged foods, water bottles
From Your Car: automotive exhaust,
Industrial: oils, stains, paints, dyes, latex, pharmaceuticals,
fiberglass, pipes, polyester, polystyrene, pesticides, herbicides
Many more things not listed here

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 US BioTek
Environmental
Pollutants (EPP)
& Urinary Metabolic
Profile (UMP)

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 What Is It?
EPP Environmental
Pollutants Panel
Important screening test to
detect exposure and excretion
capacity of 7 major
environmental chemicals
Excellent test for tough client
cases
UMP Urinary Metabolic
Profile
Urinary organic acid test, which
assesses detoxification activities: B-
12, glutathione, CoQ10
Features comprehensive metabolic
pathway analysis
Ideal when paired with EPP
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 Why Run the EPP/UMP?
EPP & UMP - tools of continued investigation into
hidden stressors, damage to metabolic pathways
and may guide/gauge expanded therapies
EPP identifies chemical toxicity & exposure
levels
UMP identifies detoxification capacities
EPP & UMP together identify chemical
toxins & hidden stressors affecting
metabolic pathways

FDN a process of continued investigation into hidden stressors

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 Clinical Objectives: When to Run The EPP/UMP

Run your basic labs

& investigate main
complaints. Initiate
Protocol
Clients main
complaints persist
Challenging
Clinical Identify deeper, hidden
presentation stressors:
warrants deeper Chemical toxicity
investigation Blunted detoxification
mechanisms

Deepen protocol
Improve function
Improve outcome

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 Who Will Benefit?
Many of your tough cases
Those with chemical sensitivities & severe oxidative stress
Clients with elevated Urinary Lipid Peroxides
Those with neurological symptoms
Expecting mothers, or those wanting to become pregnant
Clients with: tachycardia, bradycardia, fainting spells,
dizziness, frequent vomiting, nausea
Men & women with high estrogen
Men with low testosterone
Those with known MTHFR gene defects & suspected poor
detoxification

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 Deeper Look At
Specific Chemicals
Tested on The EPP

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 3 Classifications of Chemical Toxins

Mutagen - A physical or chemical agent

capable of changing genetic material and
causing genetic mutations.

Carcinogen - Any substance directly involved in

causing cancer.

Endocrine Disruptor - Chemicals which can

interfere with the endocrine system, causing birth
defects, cancer or developmental disorders.

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Mutagens
Toluene
Xylene Carcinogens
Benzene
Toluene
Styrene
Xylene
Pthalates Benzene
Endocrine Disruptors
Styrene
Pthalates
Pthalates
Parabens

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 Xylene

What Is It? Where is it found? Carpets

Aromatic hydrocarbon Fingernail polish Leather tanning
How is it harmful? Glues/adhesives Rubber & plastic
Laquers cements
Mutagenic
Octane booster in Wood stains
Carcinogenic
gasoline Cigarette smoke
Can induce neurological
Paints, paint
symptoms
thinners
Leukopenia
Cleaning solvents
Liver & renal damage

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 Toluene

What Is It?
Aromatic hydrocarbon Where is it found? Rust preventatives
Aerosals Cigarette smoke
How is it harmful?
Vehicle emissions Leather
Mutagenic preservatives
Spray paint
Carcinogenic Cosmetics
Degreasers
Reproductive toxicant
Adhesives
Developmentally toxic
Pharmaceuticals
Liver & renal damage
Varnishes
Altercation of CNS
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 Benzene & Trimethylbenzene

What Is It? Where is it found? Leather

Petrochemical, aromatic Vehicle emissions preservatives
hydrocarbon Plastic bottles
Styrofoam
How is it harmful? Carpets Pesticides
Mutagenic Solvents & paint Printing ink
Carcinogenic, especially removers Paint thinners
blood & bone cancers Tire manufacturing
Nervous system toxicant Varnishes
Inhibition of red blood cells Cigarette smoke
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 Styrene

Where is it found? Childrens toys

What Is It?
Synthetic latex Chemical spills
Petrochemical
Rubbers Landfills
Polyester Automotive parts
How is it harmful? Fiberglass Houseware
Mutagenic Piping appliances
Carcinogenic Styrofoam cups
Nervous system toxicant Polystyrene
Reproductive & Cigarette smoke
developmental toxicant
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 Pthalates

What Is It? Where is it found? Childrens toys

Petroleum-based plastic Cosmetics: nail Lubricants & oils
softener polish make-up Food wrappers &
Vinyl flooring plastic containers
How is it harmful?
Weather stripping Pool covers
Endocrine disruptor
Detergents Medical
Suppresses testosterone equipment
Plastic bottles
Reproductive & developmental toxicant
Plastic bags
Children & infants at greater risk
Insulators
May be involved in insulin resistance
PVC
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 Parabens

What Is It? Where is it found? Antifungal creams

Petroleum-based Topical & Shaving gels
preservative injectable creams Processed foods
& drugs: Benadryl
Industrial oils,
Suppositories glues, shoe
How is it harmful? Soaps, polishes, textiles
conditioners,
Endocrine disruptor
shampoos
Suppresses testosterone
Facial creams
Pro-estrogenic
Ointments
Chapstick
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Mechanisms of
Detoxification

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 Mechanisms Of Detoxification
Cellular Antioxidants Primary mechanisms
Glutathione
SOD Capturing Toxins, ex: benzene
aiding in detox

Catalase

Circulatory
Lipoic acid
Lymphatic
CoQ10
Metallothionein

Primary Organs of
Processing, Elimination,
Bile/stools Excretion
Urine Excretion Liver
Sweat Kidneys
Exhalation Bowels
Skin
Lungs

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 Glutathione - Master Antioxidant

Glutathione
Antioxidant expressed in all
cells & tissues
Vital to health & function
Essential to prevent
carcinogenesis &
mutagenesis (4,5,6) induced
by chemicals & toxic metals
Chemical metabolites have
been shown to deplete
glutathione (13)

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 Coenzyme Q10 -
Essential Mitochondrial Antioxidant

CoQ10
Essential as mitochondrial
antioxidant & for cellular
energy production
CoQ10 works synergistically
with Vitamin E
Research shows CoQ10 has
an inhibitory effect against
chemical toxins (8)

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 Vitamin B-12

Vitamin B-12
Essential cofactor in
detoxification reactions,
including methylation &
dehalogenation
Critical for DNA synthesis
& repair
Sufficient B-12 prevents
glutathione depletion (10)

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 Deeper Look At the
Urinary Metabolic
Profile (UMP):

UMP Factors Related to

Detoxification

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 Indicators of Glutathione Activity

NOTE: Healthy individuals should be excreting

a significant amount of Pyroglutamate.
Low levels, such as the test above strongly suggest glutathione depletion & severe
oxidative stress.

NOTE: a-hydroxybutyrate is ideally <50. Elevated

levels of this metabolite suggest diversion from
glutathione synthesis & increased oxidative
stress.

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 Methylmalonate (MMA) - Vitamin B-12

NOTE: B-12 deficiency is possible ONLY when MMA is

elevated.
The above test is reflective of an increasing need for B-12

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 Indicators of CoQ10 Deficiency

NOTE: Both high & low hydroxymethylglutarate can reflect

CoQ10 deficiency

NOTE: Elevated Lactate is a possible indicator of CoQ10

deficiency

NOTE: Elevated Succinate is a possible indicator of CoQ10

deficiency

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Urinary Metabolic
Profile (UMP):

Case Studies
&
Protocols

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 Case Study

Male age 50
Tests: Elevated UBAS, Elevated lipid peroxides,
stage III AF
Symptoms: IBS, Insomnia, Fatigue

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 Individuals with the
lowest excretion of
styrene, mandelate and
phenylglyoxylate are
usually the most
symptomatic.
-Mark Schauss

It is the excretion
capacity of these toxins
that is most important in
helping people to achieve
any semblance of health.
-Mark Schauss

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 Individuals with the lowest pyroglutamate
are under severe oxidative stress,
indicating difficulty recovering glutathione.

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Elevated Lactate is one marker for an
increased need for CoQ10

Remember that LOW MMA is not

significant.

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Recommended Protocol
Clinical Objectives:
Reduce oxidative stress burden
Improve glutathione/pyroglutamate status

Protocol
NAC: 200-600mg
L-Glycine: 1000-2000mg (NOTE: 2000mg and more
will increase EP excretion. Glycine is one of three
amino acids needed for GSH synthesis)
P5P: 50-100mg: precursor to glutathione synthesis
Selenium: 200mcg
B-12 (methylcobalamin): 1000mcg
Vitamin C: 1000mg
CoQ10: 250mg

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 Case: 46 year old male
Chronic Lyme disease, Chronic Fatigue
5 Consecutive Pyroglutmate levels decreased
After adding detoxification protocol, Pyroglutamate increased
significantly & symptoms improved significantly

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Liposomal Glutathione?

This person was taking liposomal

glutathione for months before this test. It
isnt likely working.

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 Identify and Reduce Exposure

Identify hidden chemicals in your clients home

Teach your clients to read labels
Minimize use of and exposure to plastics & chemicals
Decrease or eliminate consumption of pesticide-containing
foods
Replace chemical body care products with non-toxic
products
Use UMP results to formulate individualized protocols

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Increase Excretion of Chemicals
Consume only EP-free liquids to increase excretion rate,
decrease tissue load
Exercise stimulates rate of detoxification through liver &
kidney pathways
Sweat through exercise and use of sauna aids in tissue
mobilization of EPs

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Improve Detoxification Mechanisms
Hydrate, Circulate, Oxygenate
Dietary protein stimulates liver detoxification
Supplement to increase glutathione synthesis
in cells & in liver: P5P, NAC, L-Glycine,
selenium, vitamin C, B-12
Phytonutrients in cruciferous vegetables are
liver-protective & anti-carcinogenic
L-Glycine 2000-3000mg daily will increase
excretion of chemicals

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EPP/UMP Summary
US Biotek EPP - Environmental Pollutants Panel
Urine test to identify presence of multiple,
potentially harmful chemicals
Excellent for identifying H.I.D.D.E.N.
stressors

US Biotek UMP - Urinary Metabolic Profile

Compatible urine test to identify H.I.D.D.E.N.
metabolic stressors
Refines protocols & deepens clinical
investigation

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 Research
1) Kozumbo WJ, Kroll R, Rubin RJ., Assessment of the mutagenicity of phthalate esters. Environ Health Perspect. 1982
Nov;45:103-9.
2) Norppa H, Vainio H.Genetic toxicity of styrene and some of its derivatives. Scand J Work Environ Health. 1983 Apr;9(2 Spec
No):108-14.
3) James Huff* and Peter F. Infante1 Styrene exposure and risk of cancer; Oxford Journals, 4-26-11
4) Minlei Zhang, Fude Fang Prevention of chemical carcinogenesis using glutathine S-transferase-pi (GST-pi) Chinese Science
Bulletin; December 1999, Volume 44, Issue 23, pp 2168-2174
5) Regina Brigelius-Floh, Anna Kipp Glutathione peroxidases in different stages of carcinogenesis. Department Biochemistry of
Micronutrients, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal,
Germany. Biochimica et Biophysica Acta (Impact Factor: 4.66). 04/2009; 1790(11):1555-68. DOI:10.1016/j.bbagen.2009.03.006
6) Ann M. Benson, Robert P. Batzinger, Suh-Yun L. Ou, et al: Elevation of Hepatic Glutathione S-Transferase Activities and
Protection against Mutagenic Metabolites of Benzo(a)pyrene by Dietary Antioxidants,Cancer Res December 1978 38; 4486
7) TADASHI WATABE, MASAKAZU ISOBE, TADASHI SAWAHATA, KUNIE YOSHIKAWA Metabolism and mutagenicity of
styrene Supplement 2. Proceedings of the International Symposium on Styrene: Occupational and Toxicological Aspects (1978),
pp. 142-155
8) Dugosz A1, Sawicka E, Marchewka Z.Styrene and ethylene glycol have a synergetic effect on lipid peroxidation that is better
protected than repaired by CoQ10. Toxicol In Vitro. 2005 Aug;19(5):581-8.
9) Yoshifumi Ogura, Keisuke Takagi,Yoshifumi Kawarada, Ryuji Mizumoto Pathophysiological effect of hepatic ischemia and
reperfusion after hepatectomy in dogs with obstructive jaundice, focusing on the effect of coenzyme Q10 and styrene-co-maleic
acid superoxide dismutase Journal of Gastroenterology June 1996, Volume 31, Issue 3, pp 379-386
10) Watson WP1, Munter T, Golding BT. A new role for glutathione: protection of vitamin B12 from depletion by xenobiotics.
Chem Res Toxicol. 2004 Dec;17(12):1562-7.

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 Research
11) Chen RS1, Huang CC, Chu NS. Coenzyme Q10 treatment in mitochondrial encephalomyopathies. Short-term double-blind,
crossover study. Eur Neurol. 1997;37(4):212-8.
12) Boitier E1, Degoul F, Desguerre I, Charpentier C, Franois D, Ponsot G, Diry M, Rustin P, Marsac C. A case of mitochondrial
encephalomyopathy associated with a muscle coenzyme Q10 deficiency. J Neurol Sci. 1998;156(1):41-6.
13) Shawn B. Bratton , Serrine S. Lau , and Terrence J. Monks * The Putative Benzene Metabolite 2,3,5-Tris(glutathion-S-
yl)hydroquinone Depletes Glutathione, Stimulates Sphingomyelin Turnover, and Induces Apoptosis in HL-60 Cells Chem. Res.
Toxicol., 2000, 13 (7), pp 550556

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Thank you

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