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Brian Anicua

Ms. Shumate

English ll

17 May 2017

The effects on having Immunodeficiency

Many children get sick like a cold or flu, some tend to have diseases and talk

medicine to get better. In some rare cases some newborns get Severe

Immunodeficiency (SCID). This disease happens to effect the child from ever being a

normal child. SCID is a disease that affects the person/ child by body because there

body doesn't know how to handle the real world viruses and disease, many of these

children wish to live a normal live but for some its difficult because of some certain

diseases and family struggles they go through.

In this case the characterisation of cytokines that can promote proliferation (required

for retroviral transduction) of hematopoietic cells without compromising their

reconstitution capacity; the ability to concentrate vector to achieve high-titre

preparations; and the definition of optimum conditions for direct contact between the

retroviral particle and the target. All these advances contributed to the successful

treatment of children with X-linked SCID. This helps those with SCID and it make there

live more enjoyable.

It's hard to tell for newborns but overtime when the patient of older with the SCID,

they're more likely to get other types of diseases, something that their bodies can't really
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handle. Every patient's bodies different Early results demonstrated gene-transduced

cells, sustained thymopoiesis, and a diverse T-lymphocyte repertoire with normal

function. Serious adverse effects were subsequently reported in 5 of 20 patients, with T-

lymphocyte leukaemia developing, secondary to the viral vector integrating adjacent to

a known oncogene. By oncogene, that means that there bodies could grow a tumor

like cancer. This typically happens overtime but the fact that since there bodies don't

react will to other diseases then it more like an open gate to getting very sick. There are

many doctors that do studies on how this disease is attached to cancer The present

study was aimed to explore the effects of shRNA-mediated targeting of YAP gene on

human gastric cancer metastases in severe combined immunodeficiency (SCID) mice.

With the technology that is being used now there's a chance to get a great and

supportive answer

Now, there are many people in the world that go through tough time but some go

through even tougher time when there diagnosed with a terrible disease and have no

way to live there life like a normal person. SCID has many downfalls and is a disease

closer to death but thankfully there doctors trying to find an answer for this rare disease

and a type of cure/therapy

Works Cited

Works Cited
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High, Katharine. A. "Gene Therapy in Haematology and Oncology." Lancet, vol. 356,

Dec2000 Supplement, p. s8. EBSCOhost, search.ebscohost.com/login.aspx?

direct=true&db=a9h&AN=20444744&site=ehost-live.

Works Cited

Heimall, Jennifer, et al. "Current Knowledge and Priorities for Future Research in Late

Effects After Hematopoietic Stem Cell Transplantation (HCT) for Severe Combined

Immunodeficiency Patients: A Consensus Statement from the Second Pediatric Blood

and Marrow Transplant Consortium International Conference on Late Effects After

Pediatric HCT." Biology of Blood & Marrow Transplantation, vol. 23, no. 3, Mar. 2017,

pp. 379-387. EBSCOhost, doi:10.1016/j.bbmt.2016.12.619.

Works Cited

Qasim, Waseem and Andrew Gennery. "Gene Therapy for Primary Immunodeficiencies:

Current Status and Future Prospects." Drugs, vol. 74, no. 9, 15 June 2014, pp. 963-969.

EBSCOhost, doi:10.1007/s40265-014-0223-7.

Works Cited

Xia, L.Q., et al. "Silencing of Yap Gene Inhibits Metastasis in a Severe Combined

Immune Deficiency Mice Orthotopic Implantation Gastric Cancer Model." European

Journal of Inflammation (BIOLIFE, S.A.S.), vol. 12, no. 3, Sep-Dec2014, pp. 507-514.

EBSCOhost, doi:10.1177/1721727X1401200312.