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LORATADINE
Description
Structure
Synonyms
Loratadina [Spanish]
Loratadinum [Latin]
Brand mixtures
Chlor-Tripolon ND SRT
Liberator
Categories
Antipruritics
Anti-Allergic Agents
Antihistamines
Substructures
Phenylpropenes
Ethers
Aryl Halides
Halobenzenes
Isoprenes
Heterocyclic compounds
Aromatic compounds
Pharmacology
Indication
A self-medication that is used alone or in combination with pseudoephedrine sulfate for the
symptomatic relief of seasonal allergic rhinitis. Also used for the symptomatic relief of pruritus,
erythema, and urticaria associated with chronic idiopathic urticaria in patients (not for children
under 6 unless directed by a clincian).
Pharmacodynamics
Mechanism of action
Loratadine competes with free histamine and exhibits specific, selective peripheral H1
antagonistic activity. This blocks the action of endogenous histamine, which subsequently leads
to temporary relief of the negative symptoms (eg. nasal congestion, watery eyes) brought on by
histamine. Loratadine has low affinity for cholinergic receptors and does not exhibit any
appreciable alpha-adrenergic blocking activity in-vitro. Loratadine also appears to suppress the
release of histamine and leukotrienes from animal mast cells, and the release of leukotrienes
from human lung fragments, although the clinical importance of this is unknown.
Absorption
Metabolism : Hepatic
Substrate :Enzymes
Product :Loratadine
Toxicity
Affected organisms
Drug Interactions
Tacrine
The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the
anticholinergic, Loratadine, may be reduced due to antagonism. The interaction may be
beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both
agents.
Trimethobenzamide
Triprolidine
Triprolidine and Loratadine, two anticholinergics, may cause additive anticholinergic effects and
enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for
enhanced anticholinergic and CNS depressant effects.
Trospium
Trospium and Loratadine, two anticholinergics, may cause additive anticholinergic effects and
enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Food Interactions