Product Name Simparico Sentinel Sentinel Spectrum Iverhart Max

Active ingredient Sarolaner Milbemycin oxime - Milbemycin oxime, Ivermectin, Pyrantel

Lufenuron Lufenuron, and pamoate, and
Praziquantel Praziquantel

Species used on Dogs Dogs Dogs Dogs

Youngest age to be given 6 months 4 weeks 6 weeks 8 weeks
Safe in No No No No
pregnant/nursing/breeding
Mechanisms of action The pill is an acaricide Interferes with Prevents flea eggs from This anthelmintic
and insecticide that invertebrate hatching and kills the eliminates the tissue
inhibits the function of the neurotransmission and adult stage of stage of heartworm
neurotransmitter gamma eliminates the tissue stage hookworm, larvae in the dog so the
aminobutyric acid of heartworm larvae and roundworm, adults cant develop.
(GABA) receptor and adult stage of hookworm, whipworm, and
glutamate receptor. This roundworm and tapeworm.
results in uncontrolled whipworm. It also inhibits
neuromuscular activity in flea egg development.
the neuromuscular
junction and leads to
death.
Speed of kill Begins to kill fleas within Kills adult fleas within 30 Kills adult fleas within Information not provided
3 hours minutes of administration 30 minutes of
with the Capstar tablet. administration
Sentinel alone only
prevents the development
of flea eggs.
Adverse reactions Vomitting, diarrhea, Vomiting, Vomiting, Depression/lethargy,
lethargy, inappetence depression/lethargy, depression/lethargy, vomiting, anorexia,
pruritus, urticaria, pruritus, urticaria, diarrhea, mydriasis,
 diarrhea, anorexia, skin diarrhea, anorexia, skin ataxia, staggering,
congestion, ataxia, congestion, ataxia, convulsions and
convulsions, convulsions, salivation hypersalivation
hypersalivation and and weakness.
weakness.
Other parasites affected Fleas: Ctenocephalides Heartworm: Dirofilaria Heartworm: Heartworm: Dirofilaria
felis immitis Dirofilaria immitis immitis
Ticks: Amblyomma Roundworms: Toxocara Fleas: Ctenocephalides
americanum (Lone Star canis and Toxascaris felis Roundworms: Toxocara
tick), Amblyomma leonina Roundworms: canis, Toxascaris leonine
maculatum (Gulf Coast Hookworms: Toxocara canis,
tick), Dermacentor Ancylostoma caninum Toxascaris leonine Hookworms:
variabilis (American dog Whipworms: Trichuris Adult Hookworm: Ancylostoma caninum,
tick) Rhipicephalus vulpis Ancylostoma caninum Uncinaria stenocephala,
sanguineus (brown dog Fleas Whipworm: Trichuris Ancylostoma braziliense
tick) vulpi
Adult Tapeworm: Tapeworms: Dipylidium
Taenia pisiformis, caninum, Taenia
Echinococcus pisiformis
multilocularis,
Echinococcus
granulosus
How often applied Give once every month Given once every month Given once every Given once every month
month
Additional precautions Do not use in cats or let Dont give to a puppy that Dont give to a puppy Try to give on the same
children ingest is less than 2 pounds that is less than 2 day each month or the
pounds intervals will increase
between tablets and the
dose is less effective
Oral or Topical Oral Oral Oral Oral
References https://www.zoetisus.com/ http://www.virbacvet.com http://www.virbacvet.c http://www.virbacvet.co
products/dogs/simparica/p /pdf/product_pdfs/Sentine om/pdf/product_pdfs/S m/pdf/product_pdfs/IVE
df/simparica-pi-2016.pdf l_Flavor_Tabs_PIs.pdf entinel_Spectrum_PIs. RHART_MAX_Chewabl

Product Name Effitix
Active ingredient Fipronil and Permethrin
Species used on Dogs
Youngest age to be given 12 weeks
Safe in Consult your veterinarian
pregnant/nursing/breeding
Mechanisms of action The permethrin has been
known to repel fleas,
mosquitos and flies.
Fipronil works to kill adult
fleas before they can lay
eggs and it also kills adult
ticks. It also provides
waterproof protection to
deter insects.
Speed of kill 6 hours
Adverse reactions Lethargy and pruritis
(itching)
Other parasites affected Ticks: Brown dog ticks,
American dog ticks, Lone
Star ticks, and Deer ticks
Fleas, Lice, Mites, Biting
Flies, Mosquitos
pdf e_Tablets_Insert.pdf
Preventic collar Frontline Plus Heartgard for cats
Amitraz Fipronil, (S)- Ivermectin
methoprene
Dogs Dogs and Cats Cats
12 weeks 8 weeks 6 weeks
No Yes Yes
Paralyzes the mouth of the Messes up the Eliminates the tissue
tick so it is unable to development cycle of stage of the Heartworm
attach to the dog. the insect and leads to larvae and removes and
death controls the adult and
immature hookworms.
48 hours 6 hours Not listed
Allergic reaction and Lethargy and pruritis Depression/lethargy,
irritation (itching) vomiting, anorexia,
diarrhea, mydriasis,
ataxia, staggering,
convulsions and
hypersalivation
Ticks Fleas, Lice, Mites Heartworm: Dirofilaria
Ticks: Brown dog immitis
ticks, American dog
ticks, Lone star Hookworms:
ticks, Deer ticks Ancylostoma tubaeforme
and A. braziliense
How often applied Applied once every month
Additional precautions Do not allow your dog to
swallow this as it is for
external use only and is
toxic if ingested.
Oral or Topical Topical
References https://vetrxdirect.naccvp.c
om/product/basic/view/102
3127?
u=country&p=msds&prod
num=1023127
Product Name Heartgard plus for dogs
Active ingredient Ivermectin, pyrantel
Apply new collar every 3 Applied once every Give once every month
months month
Humans taking MAOI for Avoid contact with the If the cat is already
diabetes should wash treated area until it is infected with adult
hands after application dry heartworms this
and be careful because medication will only
Amitraz is used in this prevent further infections
product
Topical Topical Oral
https://vetrxdirect.naccvp. http://www.frontline.co http://www.heartguard.co
com/product/basic/view/1 m/plus/Pages/About.as m/pdf/HEARTGARD-
023044? px#what-is-it Chewables-for-Cats.pdf
u=country&p=msds&prod
num=1023044 https://vetrxdirect.nacc
vp.com/product/basic/v
iew/1111014?
u=country&p=msds&p
rodnum=1111014
https://vetrxdirect.nacc
vp.com/product/basic/v
iew/1111013?
u=country&p=msds&p
rodnum=1111013
Certifect Seresto Advantage Multi
Fipronil, (S)-Methoprene, Flumethrin, Imidacloprid, moxidectin
and Amitraz Imidacloprid
Species used on Dogs Dogs Dogs and cats Dogs and Cats
Youngest age to be given 6 weeks 8 weeks Dogs: 7 weeks Dogs: 7 weeks
Cats: 10 weeks Cats: 9 weeks
Safe in Yes Yes Consult your No
pregnant/nursing/breeding veterinarian
Mechanisms of action Eliminates the tissue Kills all stages of ticks Repels and kills ticks. Kills adult fleas and
stage of the Heartworm and breaks the flea and Also prevents tick treats flea infestation as
larvae and provides lice lifecycle infestation and kills well as controlling ear
treatment and control for fleas before they can lay mites and parasites
roundworms and eggs.
hookworms.
Speed of kill Information not provided 6 hours 24 hours 24 hours
Adverse reactions Depression/lethargy, Lethargy and pruritis Scratching, redness, hair Cough, lethargy,
vomiting, anorexia, (itching) loss vomiting, diarrhea,
diarrhea, mydriasis, inappetence, dyspnea,
ataxia, staggering, tachypnea, death
convulsions and
hypersalivation

Other parasites affected Heartworm: Dirofilaria Ticks: Deer ticks, Gulf Ticks: Dermacentor Heartworm: Dirofilaria
immitis Coast ticks, Black legged variabilis (American immitis
Roundworm: Toxocara ticks, Brown Dog ticks, dog tick), Ixodes Fleas: Ctenocephalides
canis, Toxascaris leonina American Dog ticks, Lone scapularis and Ixodes felis
Hookworm: Star ticks, Yellow Dog pacificus (deer ticks), Sarcoptic Mange
Ancylostoma caninum, ticks, European Dog ticks, Rhipicephalus Hookworm:
Uncinaria stenocephala, Wood ticks, and Paralysis sanguineus (brown dog Ancylostoma canium,
Ancylostoma braziliense ticks tick), Amblyomma Uncinaria stenocephala
Fleas americanum (Lone Star Roundworm: Toxocara
Lice tick) canis, Toxascaris leonina
Sarcoptic Mange Fleas Whipworm: Trichuris
Lice vulpis
How often applied Given once every month
Additional precautions If replacing another
heartworm preventative
product with Heartguard,
give to animal 30 days
after the last dose of
former medication. Make
sure to treat current adult
heartworms and
microfilariae first before
starting Heartguard.
Oral or Topical Oral
References http://www.heartguard.co
m/pdf/HEARTGARD-
Plus-for-Dogs.pdf
Applied once a month
Do not use on dogs that
have been diagnosed with
Diabetes or heart
problems
Topical
https://vetrxdirect.naccvp.
com/product/basic/view/1
111121?
u=country&p=msds&prod
num=1111121
Apply collar every 8 Apply monthly
months
Do not store near food Do not allow children to
or water areas and wash touch the applied site for
hands thoroughly before 2 hours after application.
touching your animal If animal is sensitive to
after placing the collar Avermectins do not use.
on them
Topical Topical
https://vetrxdirect.naccv https://vetrxdirect.naccvp
p.com/product/basic/vie .com/product/basic/view/
w/1040080? 1040051?
u=country&p=msds&pr u=country&p=msds&pro
odnum=1040080 dnum=1040051

https://vetrxdirect.naccv https://vetrxdirect.naccvp
p.com/product/basic/vie .com/product/basic/view/
w/1040079? 1040052?
u=country&p=msds&pr u=country&p=msds&pro
odnum=1040079 dnum=1040052

Product Name Activyl Bravecto Capstar Program

Active ingredient Indoxacarb Fluralaner Nitenpyram Lufenuron

Species used on Dogs and Cats Dogs and Cats Dogs and Cats Dogs and Cats
Youngest age to be given 8 weeks 6 months 4 weeks 6 weeks
Safe in No No Yes Yes
pregnant/nursing/breeding
Mechanisms of action Stops fleas from feeding,
kills adult fleas and flea
larvae, and inhibits the
development of fleas in
the environment
Speed of kill 8 hours
Adverse reactions Redness, scratching,
discomfort
Inhibits the arthropod Interferes with the Inhibits the synthesis of
nervous system and the normal nerve chitin in the development
GABA receptors of the transmission in the flea of flea larvae and eggs
fleas and ticks and leads to death
8 hours 30 minutes 30 minutes
Vomiting, pruritis, Hyperactivity, panting, Vomiting, diarrhea,
diarrhea, alopecia, lethargy, itching, lethargy (sleepiness),
decreased appetite, vocalization, vomiting, depression and itching,
lethargy, scabs, lesions fever, decreased redness and rashes of the
appetite, nervousness, skin
diarrhea, difficulty
breathing, salivation,
incoordination, seizures,
pupil dilation, increased
heart rate, and
trembling.

Other parasites affected Fleas Fleas: Ctenocephalides Fleas Fleas: Ctenocephalides

How often applied Apply monthly
Additional precautions Do not allow your pet to
lick or ingest this product
because it is toxic to them
felis felis and Ctenocephalides
Ticks: Dermacentor canis
variabilis (American dog
tick), Ixodes scapularis
(Black legged tick),
Rhipicephalus sanguineus
(brown dog tick),
Amblyomma americanum
(Lone Star tick)
Given every 90 days One time dose Given monthly or
injection every 6 months
Do not use on cats with a Do not give more than Make sure to administer
history of neurological one tablet per day the correct size tablets
abnormalities. This based on your pets size.
 product is also highly Dont split big tablets in
flammable so keep away half to give to a smaller
from heat and sparks pet.
Oral or Topical Topical Topical or Oral Oral Oral
References http://www.merck-animal- https://merckusa.naccvp.c http://ah.novartis.com.a http://www.pet-informed-
health- om/product/basic/view/10 u/pethealth_products/ca veterinary-advice-
usa.com/products/96- 47519 pstar_dog.html/section/4 online.com/program-flea-
59742-2/overview.aspx 74 control.html
https://merckusa.naccvp.c https://www.drugs.com/
https://merckusa.naccvp.c om/product/basic/view/10 vet/capstar.html
om/product/basic/view/10 47520
47493

Product Name Nexgard Ectoadvance for cats Ectoadvance plus Vectra for Cats

Active ingredient Afoxolaner Fipronil and (S)- Dinotefuran,

Fipronil & (S)-methoprene methoprene Pyriproxyfen

Species used on Dogs Cats Dogs and Cats Cats

Youngest age to be given 8 weeks 8 weeks 8 weeks 8 weeks
Safe in No Yes Yes No
pregnant/nursing/breeding
Mechanisms of action Afoxolaner blocks the Insecticide that disrupts Insecticide that disrupts Prevents all flea stages
transmission of chloride the nervous system of the nervous system of from developing
ions across the cell fleas and ticks until they fleas and ticks until they
membrane and creates die and (S)-methoprene die and (S)-methoprene
hyperexcitation of the inhibits the growth of flea inhibits the growth of
CNS, therefore killing eggs and larvae. flea eggs and larvae.
 insects.
Speed of kill 4 hours 48 hours 12 hours Kills fleas in 6 hours
Adverse reactions Vomiting, dry/flaky skin, Lethargy and pruritis Lethargy and pruritis Vomiting, diarrhea,
diarrhea, lethargy, and (itching) (itching) itching, redness at the
lack of appetite site of application
Other parasites affected Fleas: Ctenocephalides Fleas, ticks, chewing lice Fleas, ticks, chewing Kills all flea stages
felis lice
Ticks: Amblyomma
americanum (Lone Star
tick), Ixodes scapularis
(Black legged tick),
Dermacentor variabilis
(American dog tick)
Rhipicephalus
sanguineus (brown dog
tick)

How often applied Given once every month Apply monthly Apply monthly Given once every month
Additional precautions If fleas are common in Separate the treated cat Make sure to apply the Only apply behind the
the pets environment from other cats and dogs entire tube during each head in the scruff region.
year round, Nexgard for up to 24 hours use and dont divide the Do not get in your cats
should be given dose in half and give to eyes or mouth.
continually every single two separate cats.
month of the year
Oral or Topical Oral Topical Topical Topical
References http://www.nexgardfordo http://www.virbacvet.com http://vetapprovedrx.co http://www.vectrapet.co
gs.com/Style /pdf/product_pdfs/EctoAd m/ectoadvance-plus-for- m/cat/Home/About-
%20Library/nexgard/doc vance_Plus_for_Cats_MS cats-4310.html VCK/Product-
s/NexGard_PI.pdf DS.pdf Information

https://www.vetdepot.com https://www.drugs.com/v
/ectoadvance.html et/vectra-for-cats-
kittens.html
Product Name Vectra 3D for dogs Scalibor Revolution Cherisitin

Active ingredient Dinotefuran, Deltamethrin Selamectin Spinetoram

Pyriproxyfen, Permethrin
Species used on Dogs Dogs Dogs and Cats Cats
Youngest age to be given 8 weeks 12 weeks Dogs: 6 weeks 8 weeks
Cats: 8 weeks
Safe in No Consult your veterinarian Yes Consult your veterinarian
pregnant/nursing/breeding
Mechanisms of action Prevents all flea stages Kills fleas and ticks and Kills the adult fleas and Kills fleas and prevents
from developing and repels mosquitos prevents the eggs from further infestation
repels ticks, lice, flies, hatching
mosquitos and mites
Speed of kill 5 minutes 2-3 weeks 36 hours 12 hours
Adverse reactions Vomiting, diarrhea, Information not provided Pruritus, urticaria, Application site hair loss,
itching, redness at the erythema, ataxia, fever, hair change in texture,
site of application seizure, vomiting, redness, inflammation,
lethargy itching, inactivity and
vomiting.
Other parasites affected Fleas, ticks, lice, mites, Fleas: Ctenocephalides Fleas
mosquitos and flies sp. Fleas:Ctenocephalides
Ticks: (American dog felis
tick) Rhipicephalus
sanguineus (brown dog Heartworm: Dirofilaria
tick) Ixodes scapularis and immitis
Ixodes pacificus (deer
ticks) Ear mite: Otodectes
cynoti

Sarcoptic mange:
 Sarcoptes scabiei

Ticks: Dermacentor
variabilis.

Roundworm: Toxocara
cati

Hookworm:
Ancylostoma
tubaeforme

How often applied Applied once every Reapply a new collar Applied once every Applied once every
month every 6 months month month
Additional precautions Keep feline pets away Make sure to leave two Do not use on sick, Do not allow near your
from the dog for 24 finger widths between the weak or underweight pets food or water as it
hours. This medication is dogs neck and the collar. animals should never enter their
toxic to cats because they If excess collar remains mouth
cant metabolize once buckled around the
compounds in the dogs neck, cut off 2
product. inches from the buckle
and dispose wrapped in
newspaper into the trash
Oral or Topical Topical Topical Topical Topical
References http://www.vectrapet.co https://vetrxdirect.naccvp. https://vetrxdirect.naccv http://www.elanco.us/lab
m/dog/Home/About- com/product/basic/view/1 p.com/product/basic/vie els/Companion-
VDP/Product- 047301? w/3690134? Animals/Cheristin.pdf
Information u=country&p=msds&prod u=country&p=msds&pr
num=1047301 odnum=3690134
http://fleascience.com/wp
-
content/uploads/2015/05/
 Product-Label-for-
Vectra-3D-for-Dogs-and-
Puppies.pdf

Product Name Comfortis Trifexis

Active ingredient Spinosad Spinosad and milbemycin

oxime
Species used on Dogs and cats Dogs
Youngest age to be given 14 weeks 8 weeks
Safe in No Use with caution
pregnant/nursing/breeding
Mechanisms of action Kills fleas and prevents Prevention of Heartworm
and treats future flea disease and kills and
infestations prevents flea infestations.
Also treats and controls
hookworms, roundworms
and whipworms.
Speed of kill Information not provided Information not provided
Adverse reactions Vomiting, lethargy, Vomiting, pruritus,
weight loss, anorexia, lethargy, diarrhea,
diarrhea, cough, dermatitis, skin reddening,
polydipsia decreased appetite, pinnal
decreased/increased reddening
appetite, excessive
salivation
Other parasites affected Fleas: Ctenocephalides Heartworm: Dirofilaria
felis immitis
Fleas: Ctenocephalides
felis
Roundworm: Toxocara
canis, Toxascaris leonina
Hookworm: Ancylostoma
 caninum
Whipworm: Trichuris
vulpis
How often applied Given once every month Given once every month
Additional precautions If multiple animals are in Give the tablet with food
the household make sure for full effectiveness and
to treat all of them if canine vomits within an
individually with hour after administration,
approved flea product give one more full dose.
and the correct dosage Dogs should be tested for
for each species. existing heartworms first
before the first dose.
Oral or Topical Oral Oral
References http://www.elanco.us/lab http://www.elanco.us/labe
els/Companion- ls/Companion-
Animals/Comfortis.pdf Animals/Trifexis.pdf

Reference from the Drug Rep

https://ol.baker.edu/bbcswebdav/pid-1236991-dt-announcement-rid-54494645_2/courses/vet231-f2016-mu-u-t1.001/HSAH%20Flea-
Tick-HW%20Product%20Chart%202015.pdf