Epidemiology Clinical Features Diagnosis Treatment
Endocarditis Prosthetic valves Complications: High index of suspicion Antibiotics (bacteriocidal
(greatest overall) - local destructive and bacteriostatic); IV, 6 Injury to endothelium effects of bacteria Positive blood cultures weeks avg. - high velocity jet IV drug use: (greatest - embolization impacting on individual) - hematologic Visible vegetations Surgical excision surface seeding of remote (refractory bacteremia, - flow from high to MVP (most common sites New valvular regurg severe valve distruction, low pressure area structural abnormality - chronic Ab emboli, large vegetations, - flow through associated) response Minor: persistent fever, perivalvular abscess) narrow orifice vascular phenomena, Rheumatic Heart Disease Fever immunologic, thickened Antibiotic prophylaxis Bacterial resistance to valves on echo (prevention): valvular immunity Congenital Cardiac New murmur stenosis or regurg; VSD, Abnormalities: PDA, 2 major or 1 major and 3 valve replacement, MVP Platelet adherence and ventriculoseptal defect, Splenomegaly minor criteria w/ regurg; prior initiation of clotting bicuspid aortic valve endocarditis cascade Petechiae Labs: blood cultures, Microbiology: rheumatoid factor, - S. viridans Splinter hemorrhages anemia or chonic disease (overall) - S. aureus (IV drug Oslers nodes Echo: valve vegetations, abuse) perivalvular abcess - S. epidermidis Musculoskeletal (valve surgery symptoms 1st 60 days) Systemic emboli