Receptor Agonist potency Locations & selected Agonists Antagonists

type order action of agonist

all vascular smooth 1- agonists: 1- Blockers:

NE > E >> muscle, GI & urinary Prazosin, Terazosin,
sphincters, dilator muscle Tamsulosin, Trazodone
Isoproterenol of the iris, arrector pili
(isoprenaline) muscle of hair follicles NE, E, phentolamine,labetalol
Phenylephrine, Phenoxybenzamine
1 => mydriasis, TCAs: Amitriptyline,
vasoconstriction in Methoxamine, trimipramine, Doxepin,
the skin, mucosa and
abdominal viscera & Dopamine, clomipramine
Antihistamines:
sphincter contraction
of the GI tract and
oxymetazoline (H1- antagonists)
urinary bladder Hydroxyzine
Antipsychotics
Both the central and
E NE >> peripheral nervous Norepinephrine Phentolamine,
system, Pre- and Post-
isoproterenol synaptic =>negative Epinephrine, Phenoxybenzamine,
feedback control of Yohimbine, Trazodone
2 noradrenaline release Clonidine, ( is an antidepressant of the
serotonin antagonist and
Oxymetazoline reuptake inhibitor (SARI)
on liver cells, platelets,
and the smooth muscle of class)
blood vessels. Activation Typical & Atypical
of these receptors causes Antipsychotics
platelet aggregation, and
blood vessel constriction.

Isoproterenol Beta 1 receptors are Atenolol &

>E = NE located in the heart Isoproterenol Metoporolol
1 ( selective B1 blocker )
Dopamine,
Smooth muscle Dobutamine, Propranolol, Labetalol,
relaxation NE, E Nadolol, Bisoprolol
(Bronchodilation)
 2-receptors are also
mainly postsynaptic and - Blockers:
Isoprenaline > are located on a number Isoproterenol Labetalol
E >> NE of tissues including blood Salbutamol (Albuterol)
vessels, bronchi, GIT, Propranolol
skeletal muscle, liver Salmetrol
2 Timolol
and mast cell. Terbutaline
=> vasodilatation, Epinephrine Nadolol
bronchodilation,
relaxation of the GIT,
Butoxamine
glycogenolysis in the (selective 1-
liver, tremor in skeletal
muscle and inhibition
blocker)
of histamine release
from mast cells.

Isoprenaline= Enhance lipolysis, Isoproterenol

3 SR 59230A
NE > E promotes relaxation Norepinephrine
of detrusor muscle Amibegron
in the bladder Solabegron
Mirabegron