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EMBRYOLOGY
It is the study of the formation and development of the
embryo from the moment of its inception upto
the time when it is born as an infant.
Gonads: no: of chromosomes in an
organism=23 pairs/46 no.
-----44 autosomes XY
----44 autosomes - XX
Karyotyping : Classification of chromosomes
based upon their differences that enable us to
identify each chromosome individually.
Spermatogenisis : The process of formation
and development of spermatazoan .
Formed in the wall of the
seminiferous tubules of testes.
Spermiogenesis (spermateleosis) : The
process of transformation of a circular
spermatid to a spermatozoan.
Mature spermatozoan: Has a head, a neck middle piece
and a principal piece or tail. Head is covered with a cap
called acrosome.
Length -50-60 microns
Golgi apparatus forms the acrosomic cap.
Nucleus forms head.
Mitochondrion forms the sheath of middle
piece.
Proximal centriole comes to lie in the neck.
Distal centriole becomes ring shaped and forms
the annulus.
Axial filament grows out from the centriole and
is present in middle piece and tail.
Viability of spermatozoa =4 days.
FOETAL CIRCULATION
Differs from adult circulation in
a) Source of oxygenated blood is not the lung
but the placenta.
b) Oxygenated blood from placenta comes to
foetus through umbilical vein and joins the left
branch of portal vein.
Small portion passes through the substance of
the liver to I V, but the greater part passes
direct to I V through the ductus venosus.
OSTEOLOGY
Study of bones.
Bones are divided according to their
1)Position
Human skeleton -------axial} bones of skull,
vertebral column, ribs, sternum, hyoid.
-------appendicular} bones of
pectoral, pelvic girdle ,upper and lower limbs
2) Shape
Long bones: eg: Femur, tibia, humerus, ulna,
radius, and fibula
Short long bones: eg: Metacarpals,
metatarsals, phalanges
Short bones: eg: Carpals, tarsals
Flat bones: eg : Scapula , sternum, ribs,
parietal and frontal.
Pneumatic bones : Maxillary ,sphenoid ,
ethmoid, mastoid part of temporal bone.
Irregular bones: eg: Vertebrae, skull bones
Sesamoid bone: eg: patella, pisciform, fabella
2)Structure
Compact bone =consisting of haversian system
Cancellous (spongy) bone = consisting of
irregularly placed lamellae.
Diploic =consisting of inner and outer tables of
compact bone with intervening porous layer.
3)Development
Ecto chondral bones: which develop in
membrane (membranous)
Endochondral bones: which develop in
cartilage. (cartilageneous)
Ossification
Process of gradual bone formation.
a)Ossification in membrane (direct)easy
process
Eg: clavicle, bones of face,vault of skull.
b)Ossification in cartilage (Indirect) ---gradual
process.
Eg: bones of limbs, trunk.
Secondary cartilage bone: eg: neck of
mandible, sternal end of clavicle.
Primary centres of ossification may be single or multiple
,appear before birth between 6th 8th week of foetal life
except cuneiform ,navicular bones .
Secondary centres of ossification are multiple
and appear after birth except lower end of
femur.
Ossification of acetabulum is complete at 16-
17 years
Growing ends of bones of upper limbupper end of
humerus & Lower end of radius and
ulna
Growing ends of bones of lower limbs ----
lower end of femur & Upper limbs of tibia and
fibula
In long bones, growing ends fuse with shaft at
20 yrs and opposite ends at about 18 yrs.
In other bones it is between 20-25 yrs.
Foramina of skull
Anterior cranial fossa :
1.Foramen caecum: lies between the alae of
crista galli of ethmoid and frontal crest.
Transmits an emissary vein.
Folds of duramater
Falx cerebri encloses superior
sagittal sinus, inferior sagittal sinus, straight
sinus
Tentorium cerebelli- encloses
transverse sinuses, posterior petrosal sinuses.
Falx cerebelliencloses occipital
sinus
Diaphragma sellaeencloses
anterior and posterior intercavernous sinuses.
CEREBROSPINAL FLUID
(CSF)
Definition
CSF is a modified tissue fluid in the central nervous
system. It is contained in the ventricular system of brain
and the
subarad space of brain and spinal cord. CSF replaces
lymph in the CNS. It acts as a sensitive mirror which
reflects
diseases of the na system. Formation
1.The bulk of the CSF is formed by choroid plexuses of the
lateral ventricules, and the lesser amounts by the choroid
plexus
the third and fourth ventricles. '
2.Possibly it is also formed by the capillaries on
the surface of the brain and spinal cord.
Circulation
CSF passes from the lateral ventricles to the third
ventricle through foramina of Monro (interventricular
foramina). From
ventricle it passes to the fourth ventricle through cerebral
aqueduct. From fourth ventricle the CSF passes to the
subarachnoid
around the brain and spinal cord through the foramen of
Magendie and foramina of Luschka.
Absorption
1.CSF is absorbed chiefly by the arachnoid villi and
granulations, and is thus drained to the cranial venous
sinuses.
2.It is also absorbed partly by the perineural
lymphatics around I, II, VII and VIII cranial
nerves
3.And also by the veins related to the spinal
nerves.
Rate of Formation
200 cc/hour, 5000 cc/day.
Total Quantity About 150 cc.
Pressure:60-150 mm of fluid (or water).
Composition
Proteins 20-40 mg per 100 cc.
Sugar 50-75 mg per 100 cc.
Chlorides 720-750 mg per 100 cc.
Cells 0-5 per cubic mm
Functions
It is (a) protective, (b) nutritive, and (c)
excretory to the CNS.
Applied Anatomy
1.CSF can be obtained by (a) lumbar puncture, (b)
cisternal puncture, or (e) ventricular puncture. Lumbar
puncture is 1st
method of all and is commonly used. It is done in the
interspace between third and fourth lumbar spines.
2.Biochemical analysis of the CSF is of
diagnostic value, as the cases of meningitis
and spinal tumours.
3.Drainage of CSF at regular intervals is of therapeutic
value in meningitis. Certain intractable headaches of
unknown are
also known having been caused by a mere lumbar
puncture with drainage of CSF.
4.Obstruction to the flow of CSF in the ventricular system
of brain leads to hydrocephalus in children .Spinal
obstruction
leads to Froins syndrome.
Constrictions in oesophagus :
at commencement 15 cm from incisor teeth.
at crossing over by aortic arch 22.5 cm from
incisor teeth.
at crossing over by left principal bronchus 27.5
cm from incisor teeth.
at its point of piercing diaphragm 40 cm from
incisor teeth.
Stomach :
Cardiac orifice Behind left 7th costal cartilage
1" from its junction with sternum.
Pyloric orifice 1.2 cm (0.5") to the right of
midline on transpyloric plane.
Capacity at birth 30 ml; adults 1500 ml.
Length of small intestine: 6 to7 metres
Length of duodenum: 10 or 25 cm
1 st part: 5 cm
2nd part: 7.5 cm
3rd part: 10 cm
4th part: 2.5 cm
Length of large gut: 1.5 metres
Anal canal
Hilum of kidney Transpyloric plane (LI).
Kidney:Length: 11 cm, Breadth : 6 cm,
Antero-posterior diameter: 3 cm
Length of Ureter : 25 cm
Length of male urethra: 18-20 cm
Spermatic cord : 9-10 cm
Length of inguinal canal: 4 cm
Testis: Length-4.5 cm, Breadth-2.5cm,
Anteroposterior dr-3
Ovary: Length -3 cm, Width-1.5
cm,Thickness-1 cm
Uterus: Length-7.5 cm, Breadth-5 cm,Antero-
posterior diameter-2.5 cm
Weight :30 to 40 gms
Uterine tubes: Length-10 cm
Saphenous opening Height 1.5 to 8 cm;
Width 1 to 3 cm
Femoral sheath Length 3 to 4 cm.
Femoral canal Length 1.25 cm.
Tendo calcaneus Length 15 cm.
Weight of spinal cord 30 gms.
Length of spinal cord 45 cm.
Filum terminale 20 cm.
Internum 15 cm.
Externum 5 cm.
Commencement of spinal cord Cranial
border of C1 vertebra (Atlas).
Termination of spinal cord - lower border of
LI or disc between LI & L2 vertebrae.
Cervical enlargement of spinal cord
Circumference 39 mm. Extends from LI to SI
spinal segments.
Lumbar enlargement of spinal cord
Circumference 35 mm. Extends from LI to S3
spinal segments.
Descent of testis:
At deep inguinal ring 7th month of intra
uterine life.
In inguinal canal 8th month of intrauterine
life.
At superficial inguinal ring 9th month of
intrauterine life.
Remnants
Remnant of ductus arteriosum is Ligamentum
arteriosum.
Ductus venosum Ligamentum venosum.
Urachus Median umbilical ligament.
Left umbilical vein Ligamentum teres of liver.
Right umbilical vein Disappears.
Vitello-intestinal duct Meckel's diverticulum.
Distal part of umbilical artery Medial umbilical ligament.
Proximal part of umbilical artery Superior vesical artery.
Wolfian duct Gartner duct (Gives rise to vaginal cyst).
Wolfian tubule Paraoophoron, Eoophron.
Left anterior cardinal vein Oblique vein of Marshall.
End Arteries
Artereis which do not anastomose with their adjacent one
are called end arteries. e.g.
(i) The best example being central artery of retina.
(ii) Central branches of central arteries.
(iii) Vasa recta of mesenteric arteries.
(iv) Arteries of spleen, kidney, and metaphysis of long
bones.
ABDOMEN
IMPORTANT RELATIONS
Relations of bile duct
A.Supraduodenal part (in the free margin of lesser
omentum)
1. Anteriorly : liver 2. Posteriorly : portal vein and
epiploic foramen.
3. To the left: hepatic artery.
B.Retroduodenal part
1. Anteriorly : first part of duodenum 2. Posteriorly :
inferior vena cava
3. To the left: gastroduodental artery
C. Infraduodenal part
1. Anteriorly : a groove in the upper and lateral parts of
the posterior surface of the head of the pancreas.
2. Posteriorly : inferior vena cava. 3. Relations of the
Kidneys
THORAX
MEDIASTINUM AND ITS CONTENTS
Subdivisions of Mediastinum
Superior mediastinum
Locationfrom inlet of thorax to plane extending from
level of sternal angle anteriorly to lower border of T4
vertebra posteriorly
Contents
a. Muscles attached to sternum (sternothyroid and
sternohyoid)
b. Remnants of thymus gland
c. Vessels
1. Arch of aorta
2. Origin of brachiocephalic, left common carotid, and left
subclavian arteries
3. Left and right branchiocephalic veins
4. Superior vena cava
d. Trachea
e. Esophagus
f. Nerves and plexuses
1. Vagusright and left
2. Left recurrent laryngeal
3. Phrenicright and left
4. Cardiac plexus (superficial)
g. Lymphatics
1. Brachiocephalic and tracheobronchial nodes
2. Thoracic duct
Inferior mediastinumhas three subdivisions that extend
downward from lower border of superior mediastinum to
diaphragm
1. Anterior mediastinum
a. Locationposterior to body of sternum and attached
costal cartilages, anterior to heart and
pericardium
b. Contents
1. Fat
2. Remnants of thymus gland
3. Anterior mediastinal lymph nodes
2. Middle mediastinum
a. Locationbetween anterior mediastinum and posterior
mediastinum
b. Contents
1. Heart and pericardium
2. Beginning or termination of great vessels
3. Pulmonary arteries and veins
4. Phrenic nerves
5. Bifurcation of trachea
6. Tracheobronchial lymph nodes
7. Cardiac plexus (deep)
Posterior mediastinum
a. Locationposterior to heart and pericardium, anterior to
vertebrae T5-T12
b. Contents
1. Esophagus
2. Descending aorta and origins of posterior intercostal
arteries
3. Azygos system of veins and termination of posterior
intercostal veins
4. Nerves
a. Vagus nerves
b. Splanchnic nerves
5. Lymphatics
a. Thoracic duct
b. Posterior mediastinal nodes
c. Tracheobronchial nodes
d. Bronchomediastinal trunk
Sympathetic Parasympathetic
system(thoracolumbar system(craniosacral
outflow) outflow)
Adrenergic cholenergic
Spleenic contraction
Coronary vasodilatation
Ciliary ganglion,
pterygopalatine
ganglion,oticganglion,
submandibular ganglion.