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Intrinsic Extrinsic
Contact activated-contact negative Injury activated-TF combines activate
charge surface FVII
Physical Groupings
PROTHROMBIN FIBRINOGEN CONTACT GROUP
(1972) 15813 1112/1211
2,7,9,10 -1,5,8,13 -11,12
Protein C, S, Z(CSZ) -Thrombin acts on all -HMWK, PK
-Vitamin K dependent these factors
-Synthesized-liver -Synthesize-liver -synthesize in the liver
-SMALL MW 50,000- -LARGE MW 250,000 LARGE 80,000-173,000
100,00 -Except F8, vWF -activated upon contact on
-Domain critical for Ca -endothelial cells and negatively charged
binding megakaryocyte particle
-Heat Stable -All are consumed in the -not consumed in
-Inhibited by Warfarin clotting process coagulation, found in
serum
-ACTIVATE intrinsic and
fibrinolytic system
-liver parenchymal
disease
-vit K deficiency