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111 minutes
111 marks
Page 1 of 36
Q1. A child has a sore throat. The mother takes the child to the doctor. The doctor says that the
child has a bacterial infection.
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(Total 2 marks)
Q2. (a) Explain, as fully as you can, how the bodys white blood cells respond to infections.
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(4)
(b) Describe, in as much detail you can, how one method of immunisation protects us from a
named disease.
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(3)
(Total 7 marks)
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Q3. (a) Antibodies help to defend the body against disease. The diagram represents the
reaction of antibody and antigen for disease X.
Using the diagram to help you, suggest why the body's defence against disease X would
not be effective against disease Y.
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(2)
(b) Tuberculosis is a disease which is caused by a bacterium. The body is able to produce
antibodies to destroy the bacteria which cause the disease. Some people are naturally
immune. A person can be tested to find if they are immune.
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(i) Suggest the possible cause of the reaction when a person who is already immune is
tested, as shown in diagram A.
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(2)
(ii) Explain why the injection of tuberculosis bacteria (diagram B) causes immunity but
does not cause the disease.
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(Total 7 marks)
Q4. Penicillin is an antibiotic which stops bacteria from reproducing. It was used a lot in the past
to treat bacterial infections in humans and other animals. In many hospitals there are now
strains of penicillin resistant bacteria.
Explain how natural selection could have produced these strains of penicillin resistant bacteria.
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(Total 5 marks)
Page 4 of 36
Q5. The diagram shows two methods which are used to give humans protection against
disease. Method A shows active immunity and Method B shows passive immunity. Method A
can be used against polio. Method B is often used against tetanus.
(a) What is the name of the substances produced by the body which destroy harmful viruses
and bacteria?
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(1)
(b) Why does Method A give long lasting protection against polio?
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(c) Why does Method B not give long lasting protection against tetanus?
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(d) In immunisation against polio a second dose of the weakened virus is given (this is known
as a booster). Suggest why this booster is necessary.
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(1)
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(e) Method A would not be helpful for a person who had just been infected with tetanus
bacteria. Explain the reason for this.
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(2)
(f) Why is Method B very good for dealing quickly with an infection of tetanus?
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(1)
(Total 7 marks)
Q6. Hepatitis B is a liver disease caused by a virus. The virus is found in body fluids such as
blood, saliva and urine. Diagram 1 shows the structure of the virus in cross section.
Diagram 1
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(a) The human body has several natural defences against viruses. Some of these prevent
viruses from entering the body. Others act once the viruses have entered.
Diagram 2
(1)
(ii) What type of chemical is released by some white blood cells to attack viruses?
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(1)
(b) Hepatitis B is more likely to be spread among people who share needles when they inject
drugs. Use information given at the beginning of this question to explain why this is so.
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(2)
(Total 4 marks)
Q7. (a) (i) Some diseases can be tackled by using antibiotics and vaccination.
Explain fully why antibiotics cannot be used to cure viral diseases.
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(2)
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(ii) A recent study found that babies in 90 % of hospitals are infected with the MRSA
bacterium.
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(2)
(b) A person can be immunised against a disease by injecting them with an inactive form of a
pathogen.
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(Total 7 marks)
##
The table shows changes in resistance to the antibiotic penicillin in one species of bacterium
between 1991 and 1996.
1991 92 7
1993 94 14
1995 96 22
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(1)
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(ii) Use the data in the table to suggest why the doctor should not prescribe penicillin.
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(Total 3 marks)
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(2)
The graph shows the death rate in Liverpool during three influenza epidemics.
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(i) The population of Liverpool in 1951 was approximately 700 000.
Calculate the approximate number of deaths from influenza in week 4 of the 1951
epidemic.
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(ii) In most years, the number of deaths from influenza in Liverpool is very low.
Explain, in terms of the influenza virus and the bodys immune system, why there
were large numbers of deaths in years such as 1918 and 1951.
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(3)
(Total 7 marks)
Q10. The MMR vaccine is used to protect children against measles, mumps and rubella.
(a) Explain, as fully as you can, how the MMR vaccine protects children from these diseases.
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Page 10 of 36
(b) Read the passage.
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(2)
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(Total 6 marks)
Page 11 of 36
Q11. Pathogenic bacteria and viruses may make us feel ill if they enter our bodies.
Bacteria .....................................................................................................................
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Viruses .......................................................................................................................
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(2)
(b) Most drugs that kill bacteria cannot be used to treat viral infections.
Explain why.
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(2)
Explain, as fully as you can, why there has been a large increase in the number of
antibiotic-resistant strains of bacteria.
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(Total 8 marks)
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Q12. Polio is a disease caused by a virus. In the UK, children are given polio vaccine to protect
them against the disease.
(a) In the sentences below, draw a ring around the correct words in each box.
produces antitoxins
(1)
active
(ii) The vaccine contains an infective form of the polio virus.
inactive
(1)
antibiotics
produce antibodies which destroy the virus.
drugs
(1)
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(b) The graph shows the number of cases of polio in the UK between 1948 and 1968.
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How many years did it take for the number of cases of polio to fall to zero?
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(iii) There have been no cases of polio in the UK for many years. But children are still
vaccinated against the disease.
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(1)
(Total 6 marks)
Page 14 of 36
Q13. Many people who are overweight try slimming programmes.
A research study evaluated four different slimming programmes over 6 months.
Scientists selected a group of 40 people for each slimming programme and a control group.
Each of the five groups was matched for age, gender and mass.
The graph shows the results of the study.
Adapted from British Medical Journal, 2006, volume 332, pages 1309 1314.
(a) Give two control variables that were used in this study.
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(b) Give two conclusions that can be drawn from the results of this study.
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(c) The costs of the four programmes were:
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(Total 8 marks)
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(1)
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(b) The graph shows how the percentages of obese men and women in the UK changed
between 1994 and 2004.
(i) Describe how the percentage of obese women changed between 1994 and 2004.
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(2)
(ii) The percentage of obese men changed between 1994 and 2004.
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(2)
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(c) The chart below is published by the British Heart Foundation. It shows how death from
CHD is related to a number of different factors.
The bigger the circle, the more people are affected by the factor.
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(1)
(ii) Estimate the percentage of deaths from CHD related to high blood pressure.
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(1)
(iii) The data are shown as overlapping circles instead of a bar chart. The percentages
of deaths related to the different factors add up to more than 100%.
What does this tell you about some of the people who died from CHD?
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(1)
(Total 8 marks)
Page 18 of 36
Q15. Dr Semmelweiss collected data about the number of deaths in the two maternity wards in
the hospital where he worked.
From 1833 to 1838 there were the same number of doctors and midwives delivering
babies in both Ward 1 and Ward 2.
From 1839 to 1847 medical students and doctors delivered babies in Ward 1; midwives
delivered babies in Ward 2.
Dr Semmelweiss also noticed that doctors often came straight from examining dead bodies to
the delivery ward.
The table shows the number of patients and the number of deaths in the two wards.
Death rate as
Number of Number of
Years Ward deaths per
patients deaths
1000 patients
death rate =
to calculate the death rate for Ward 2 in the years 1839 - 1847.
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(ii) Suggest a hypothesis for the difference in the death rates on Ward 1 and
Ward 2 in the years 1839 - 1847.
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(2)
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(b) Antibiotics are now used in hospitals.
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(d) How can the work of Semmelweiss help to reduce the problems caused by MRSA?
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(Total 8 marks)
Q16. Many diseases are caused by viruses. Children are given vaccines to protect them against
viral disease.
viruses ......................................................................................................... .
Page 20 of 36
(b) In the 1990s many people thought that the MMR vaccine caused autism in some children.
This is why the Japanese government stopped using the MMR vaccine.
The graph gives information about the percentage of Japanese children who developed
autism during the 1990s.
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The data in the graph support the view that there is no link between MMR vaccination and
autism.
Explain why.
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(4)
(Total 7 marks)
Q17. Read the passage about the use of antibiotics in food production.
People do not always agree about the use of antibiotics in food production.
Some farmers put low doses of antibiotics in feed for animals such as cattle and
sheep. Antibiotics help to keep animals disease-free. Antibiotics also help animals to
grow.
The use of antibiotics in livestock feed means that there is a higher risk of antibiotic-
resistant bacteria developing. These could be dangerous to human health.
(a) Explain how a population of antibiotic-resistant bacteria might develop from non-resistant
bacteria.
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(3)
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(b) Suggest two reasons why it is an advantage to keep farm animals disease free.
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(2)
(Total 5 marks)
On Ward 2, babies were delivered by midwives. The midwives did not work on other
wards.
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(a) (i) 600 mothers gave birth on Ward 2 in 1845.
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Using data from the bar chart, give a reason for your answer.
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(b) In January 1848, Dr Semmelweiss asked all doctors to wash their hands before delivering
babies.
The table shows the number of deaths on the two wards in 1848.
Ward 1 3
Ward 2 1
(ii) What was the effect on the death rate on Ward 1 of doctors washing their hands
before delivering babies?
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(1)
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(1)
(Total 6 marks)
Page 24 of 36
M1. bacteria reproduce rapidly / increase rapidly in numbers produce poisons / toxins
each for 1 mark
2
[2]
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(ii) any three from
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(c) antibodies removed (from blood);
accept destroyed or
unable to make or
replace antibodies or
they are not human antibodies or
person has not made own antibodies
1
M6. (a) (i) diagram shows extensions of intact cell membrane around viruses
1
(ii) antibodies
allow enzymes re (ii)
allow interferon
ignore antitoxins / proteins
1
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(b) virus is transferred
1
(ii) mutation
ignore mutation caused by antibiotic
1
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(ii) any two from:
difficult for drugs to enter (body) cells / drug would kill (body) cell
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(ii) any three from:
by white cells
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(b) (i) (no)
no control used
2
(ii) (yes)
being paid by parents / lawyers
1
[6]
overuse of antibiotics
bacteria mutate
do not allow antibiotic causes mutation
reduced competition
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M12. (a) (i) lives inside cells
1
(ii) inactive
1
(iii) antibodies
1
(ii) 8 (years)
1
age
gender
mass
number in group
time
2
(c) (Atkins)
costs least
1
mass loss very similar to other diets or second highest mass loss
or as effective as other diets
1
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(d) any two from:
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(ii) women in Ward 1 infected
1
inactive
1
antibodies
1
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M17. (a) idea that bacteria mutate or that there is variation in bacteria
1
(ii) (ward 2)
or
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Page 36 of 36