UX-2000

Product Technology & Features

Copyright 2011 PT Sysmex Indonesia PT Sysmex Indonesia

Slide 1
 Content
Principles
Features
Integrated model
Advanced Technology
Flowcytometry
Friendly User
SNCS
Aids in Diagnosis Patient
UTI
Hematuria
Conductivity
Early stage nephropathy
Summary

Copyright 2011 PT Sysmex Indonesia Slide 2 PT Sysmex Indonesia

 UX-2000
Worlds First Fully Automated Integrated Urine Analyzer

Copyright 2011 PT Sysmex Indonesia Slide 3 PT Sysmex Indonesia

CHM Analysis Parameters

Urobilinogen

Keton body

Nitrite salt

Micro-Alb
Creatinin

Turbidity
Glucose

Specific
Gravity*
Protein

Bililbin
Blood

Color
WBC
pH
Name

Meditape9U N/A N/A I I I

Meditape10U N/A I I I

Meditape10K N/A I I I

Meditape 9U : Basic parameter of screening

Meditape 10U: Basic parameter of screening + CRE (For
concentration correction)
Meditape10K : Kidney disorder screening including m-Alb + CRE

* I = Performed by CHM Unit = Performed by Dipstick

Slide 4
UX-2000 Principle - CHM

Strips
Detector LED
LED
(Photo Diode)
Dual-
Wavelength
Reference
Method
Test Strip

Slide 5
UX-2000 Principle - CHM

Specific
Light Flow Cell Sample Prism Slit
Gravity (LED)

Transmission
Refractometry S.G.-Unit
Method

CCD-sensor

Slide 6
UX-2000 Principle - CHM

Cylindrical Cell
Photodiode
Color 470/525/635nm
Multi-LED
(Transmitted
light)
Hue
Reflectivity
Measurement
Method Photodiode
(Scattered light)

23 combination colors
NORMAL

Slide 7
UX-2000 Principle - CHM

Cylindrical Cell
Photodiode
470/525/635nm
(Transmitted
Turbidity Multi-LED light)

Light Scattering
Measurement
Method

Photodiode
(Scattered light)

Slide 8
 UX-2000 Principle - FCM
Fluorescence flow cytometry method using 635nm red
semiconductor laser

Copyright 2011 PT Sysmex Indonesia Slide 9 PT Sysmex Indonesia

 UX-2000 Features & Benefits

Copyright 2011 PT Sysmex Indonesia PT Sysmex Indonesia

Slide 10
 Integration
(Operator)

Aids in
Advanced
diagnosis
technology
patient
(Managerial)
(Clinicians)

Copyright 2011 PT Sysmex Indonesia Slide 11 PT Sysmex Indonesia

 Integration (and automation)

CHM FCM UX-2000

Consolidated analysis result

Comprehensive urinalysis result
Crosscheck function helps user in analysis samples

Consolidated workflow
Fast TAT with troughput approx. 100 samples/h (chemistry+sediment)
Less time spent in operating different instruments

Compact design
Saves space in labs with limited work area

Copyright 2011 PT Sysmex Indonesia Slide 12 PT Sysmex Indonesia

 Comprehensive Analysis Result

Scattergrams &
CHM results Histograms

FCM results Research

parameters

Crosscheck flag

Copyright 2011 PT Sysmex Indonesia Slide 13 PT Sysmex Indonesia

Appendix 1

Crosscheck Function
Check if 2 parameters
relating each other are
consistent or not

User-definable

Up to 10 conditions

Examples:
BLD x RBC
LEU x WBC
NIT x BACT
PRO x CAST

Slide 14
Appendix 2

Reflex Test
Automatically order a FCM
test according to CHM result
User-definable
Up to 10 conditions
SG, Turbidity and Color can
be used
Application choices:
sediment analysis or bacteria
only analysis
Examples:
GLU > 1.70mg/dL and
PRO > 2.10mg/dL

Slide 15
 Integration (and automation)
Standardization
Eliminates subjectivity (e.g. in urine strip color determinations,
urine particle recognition under microscope)
Eliminates error-prone analysis and minimizing causes of
variance (e.g. Aspirated sample volume, centrifugation, etc)

Copyright 2011 PT Sysmex Indonesia Slide 16 PT Sysmex Indonesia

 Advanced Technology
Flowcytometry proven technology
Dedicated sediment and bacteria channels for high sensitive
measurement
User-friendly software
SNCS available

Copyright 2011 PT Sysmex Indonesia Slide 17 PT Sysmex Indonesia

 Advanced Technology

Copyright 2011 PT Sysmex Indonesia Slide 18 PT Sysmex Indonesia

 What is SNCS?
Software program developed by Sysmex Corporation

SNCS SV at Sysmex
Questra SV in Japan

CRM system at SAP

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 SNCS services

Scientific
Remote Preventive Remote
Online QC tools e.g.
service maintenance version up
Case study

Copyright 2011 PT Sysmex Indonesia Slide 20 PT Sysmex Indonesia

 SNCS on UX-2000

Online QC
3 lots of QC are chosen
Send QC results to server
Real time

Remote service
Sysmex & customers share same IPU screen
Error log automatically send to server when instrument is shut
down

Copyright 2011 PT Sysmex Indonesia Slide 21 PT Sysmex Indonesia

 SNCS Summary
Better quality control
Real time online QC
Integrate into laboratory computer network system
Improve laboratory operation
Increase customer satisfaction
Customer retention
Increase instrument value
Shorten downtime FREE of
Charge

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 Aids in Diagnosis Patients
UTI,
(Bacteria count, Leucocyte count, Leucocyte Esterase and Nitrite)
Hematuria (vs Hemoglobinuria),
(Erithrocyte count, Erythrocyte morphology, and Blood)
Conductivity of urine,
Early kidney diseases,
(A/C ratio and creatinine parameters)

Using spot urine (instead of 24h urin for albumine and creatinine
parameters), within minutes.

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 Protein : Creatinine (P/C) ratio
Persistent increased proteinuria is a sign of renal disease
Amount of protein excretion is a reflection of severity of the
disease

P/C results:
Diagnose patients with renal diseases
Monitor patients with renal diseases

Copyright 2011 PT Sysmex Indonesia Slide 26 PT Sysmex Indonesia

 Microalbumin : Creatinine ratio
(A/C ratio)
Albumin
Relatively small, often among the first proteins to enter the
urine after glomeruli are damaged

Microalbumin: low volume of albumin appear urine

Even minor kidney dysfunction is detectable with proper

diagnosis of microalbuminuria

Effective indicator for early detection of diabetic

nephropathy

Copyright 2011 PT Sysmex Indonesia Slide 27 PT Sysmex Indonesia

 Conductivity
Conduction is due to ions in the urine
Conductivity is influenced by the ion density
e.g. Sodium

High correlation coefficient between urine conductivity and

osmolality
Can be an indicator of renal failure
Useful marker for diuresis and antidiuresis state of the patients

Analysis results are indicated by numerical data and urine

concentration flags (rank values)

Copyright 2011 PT Sysmex Indonesia Slide 28 PT Sysmex Indonesia

Summary Operational view point

Features Advantages Benefits

Integrated Model Consolidated workflow Fast TAT
Comprehensive result Saves time in operating
High speed performance instrument
Easy to operate Increase confidence in result
Result in one screen reporting due to proven FCM
Standardized analysis technology, and crosscheck function
Compact design available
Less time spent on training
Customers are able to spend more
time on validating or reviewing
pathological samples
Eliminates human errors and
subjectivity
Saves space in labs with limited
work area

Slide 29
Summary Managerial view point
Feature Advantages Benefits
Advanced Technology FCM proven technology Decrease labor cost by
User-friendly software spending less time on
Dedicated sediment and screening all samples but
bacteria channels for high focus on pathological samples
sensitive measurement only
SNCS available Easy to operate, spend less
time on training and
troubleshooting
On-line QC for real time QC
result comparison with peer
group
Remote service to shorten
troubleshooting time, thus
decrease down time of
instrument

Slide 30
Summary Clinical view point
Feature Advantages
Aids in patient Microalbumin parameter
diagnosis available for A/C ratio
P/C ratio available
Value-added clinical
information: RBC morphology,
UTI info, Conductivity info
Slide 31
Benefits
Spot urine is used, more
convenient for patients
Screening test for early
detection of kidney disorder
and diabetic nephropathy
which leads to better patient
outcome
Aids in differentiating
glomerular and non-
glomerular kidney disease ->
timely patient management
from clinicians