Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
ORGANOGENESIS
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STANDAR KOMPETENSI DOKTER INDONESIA
( SKDI ) 2012
LEVEL OF COMPETENTCY: 1 OR 2
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PROCESS & STAGES OF HUMAN DEVELOPMENT
SPERMATOZOON X OVUM
FERTILIZATION
CONCEPTUS
CLEAVAGE
STAGES OF DEVELOPMENT
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ORGANOGENESIS
DIFFERENTIATION
TERATOGENES
CRITICAL PERIOD
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PATHWAYS TO FERTILIZATION
VAGINA
3 CC EJACULATE ( 200 MILLIONS 300 MILLIONS SPERMATOZOA )
DAY 14 1 BEFORE NEXT MENSTRUATION : OVULATION : EXPELL
OF OVUM & SURROUNDING FOLLICULAR CELLS FROM OVARY
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FERTILIZATION AND DEVELOPMENT OF CONCEPTUS
MORULA
BLASTOCYST CAVITY
BLASTOMERE
FERTILIZATION: CAPACITATION, ACROSOMIC REACTION,
MEMBRANE PENETRATION, ZONA REACTION. 7
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IMPLANTATION ( NIDATIO , FECUNDATIO )
DAY 5 / 6 - 11 / 12
THREE STAGES :
1. MUSCULAR
2. ADHESIVE
3. INVASIVE
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DIFFERENTIATION OF BLASTOCYST
WEEK 2
EMBRYONIC POLE
( POLUS EMBRYONALIS )
INNER CELL MASS
EMBRYOBLAST
BLASTOCYST CAVITY
1. EMBRYOBLAST
1.1.ENTODERM(CUBICAL CELLS)
1.2.ECTODERM
(COLUMNAR CELLS)
2.TROPHOBLAST
2.1. CYTOTROPHOBLAST
(LANGHANS CELLS,
MONONUCLEATED)
2.2. SYNCYTIOTROPHOBLAST
( MULTINUCLEATED CELLS )
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DISCUS EMBRYONALIS TRILAMINARIS
WEEK 3 :
PROCHORDAL PLATE
CRANIAL INVAGINATION
ENTODERM
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DEVELOPMENT OF ECTODERM
BEGINNING OF WEEK 3
AMNION
NEURAL PLATE
NEURAL CREST
* (CRISTA NEURALIS) 12
DEVELOPMENT OF ECTODERM
END OF WEEK 3
NEURAL PLATE
LATERAL FOLDING
PRIMITIVE STREAK
NEURAL CREST
NEURAL FOLD
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FORMATION OF NEURAL TUBE
LATERAL FOLDING
NEURAL GROOVE
NEURAL CREST
ELONGATION
BRAIN ( ENCEPHALON )
SOMITES
ELONGATION
POSTERIOR NEUROPORE
(CLOSURE : 27TH DAY / 25 SOMITES STAGE)
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DERIVATIVES OF ECTODERM
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DIFFERENTIATION OF MESODERM
AMNIOTIC CAVITY
3.INTERMEDIATE MESODERM
ECTODERM
ENTODERM
MESODERM
NOTOCHORD
1.PARAXIAL MESODERM
2. LATERAL MESODERM
LATERAL
THIN LAYER FOLDING
DAY 17: 3 PARTS
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DIFFERENTIATION OF MESODERM
END OF WEEK 3
PARAXIAL MESODERM
SOMITES
LATERAL MESODERM :
1. PARIETAL(SOMATIC)
MESODERM
2. VISCERAL MESOD.
(SPLANCHNIC MESOD)
INTERMEDIATE MESODERM
INTRAEMBRYONIC COELOM
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DERIVATIVES OF MESODERM
NEURAL TUBE
PARAXIAL MESODERM
LATERAL MES.
SOMITE
SCLEROTOME
INTERMEDIATE MESODERM
CARTILAGE
KIDNEY
MYOTOME
GONADS
MUSCLE
SOMATIC SPLANCHNIC
DERMATOME
CIRCULATORY SYSTEM
DERMIS
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BODY CAVITY & ORGANS LINING/MEMBRANE 19
DIFFERENTIATION OF ENTODERM
PEDUNCULUS VENTRALIS
ALLANTOIS
ANT.& POST. INTESTINAL PORTALS
FORE GUT
HINDGUT
ECTODERM
ENTODERM
MIDGUT
VITELLINE DUCT
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DIFFERENTIATION OF ENTODERM
LUNG BUD
LIVER BUD
MIDGUT
VITELLINE DUCT
CLOACA
VITELLINE DUCT
BUCCOPHARYNGEAL MEMBRANE
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DERIVATIVES OF ENTODERM
BUCCOPHARYNGEAL MEMBRANE
RESPIRATORY BUD
HEPATIC BUD
FORE GUT
MOUTH (CAVUM ORIS), ESOPHAGUS
GASTER, DUODENUM, PANCREAS,
LIVER, GALL BLADDER & LUNGS
MID GUT
MESENTERIAL INTESTINE(JEJUNUM
& ILEUM ) & PROXIMAL COLON.
HIND GUT
DISTAL PARTS OF COLON & UPPER
PORTION OF ANAL CANAL
CLOACAL MEMBRANE
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TERATOLOGIA
DEFINITIONS
BRANCH OF EMBRYOLOGY THAT STUDY ABNORMAL
DEVELOPMENT OF CONCEPTUS ( CONGENITAL MALFORMATION )
INCLUDING ITS END RESULT
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ETIOLOGY OF CONGENITAL MALFORMATION
CONGENITAL MALFORMATION
ENVIRONMENT : 10%
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ENVIRONMENT ETIOLOGY
1. INFECTIOUS AGENTS:
1.1. VIRUS : TORCH , MEASLES
1.2. BACTERI : TREPONEMA PALLIDUM ( SYPHILIS )
2. RADIATION :
ATOMIC BOMB ( HIROSHIMA , NAGASAKI ) , X-RAY
3. CHEMICALS :
3.1. DRUGS : TERATOGENIC DRUGS ( THALIDOMIDE ,
ANOREXOGENIC DRUGS )
3.2. ALCOHOL
3.3. NICOTINE / CIGARETTES
3.4. ENVIRONMENTAL CHEMICALS : ORGANIC MERCURY
( MINAMATA BAY DISEASE )
4. HORMONES :
PROGESTINE , MATERNAL DIABETES
5. FOOD / NUTRIENTS DEFICIENCY
6. HYPOXIA
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MECHANISM OF CONGENITAL MALFORMATION
1. STAGNANT
1.1. AGENESIS : RENAL AGENESIS
1.2. STOP AT CERTAIN STAGE OF DEVELOPMENT :
1.2.1. PATHOLOGIC UMBILICALIS HERNIA
1.2.2. PALATOSCHIZIS
1.2.3. ATYPIC DIFFERENCIATION : CONGENTAL TUMORS
2. PROGRESSIVE
2.1. EXCESSIVE FORMATION :
2.1. GEMELLI
2.2. GIGANTISMUS
2.3. POLYDACTILIA
2.2. MISPLACEMENT : ECTOPIA TESTIS
2.3. DISPLACEMENT : DEXTROCARDIA
2.4. UNION : REN UNGUIS
2.5. SPLIT : URETER BIFIDA
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MECHANISM OF CONGENITAL MALFORMATION
3. REGRESSIVE.
3.1. FAILURE OF CLEAVAGE : CYCLOPIA
3.2. PERSISTENT : PERSISTENT ANAL MEMBRANE
3.3. UNION FAILURE : ACCESSORY SPLEEN
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REFERENCES
1. Dawn A Tamarkan, Ph D : University of Wisconsin : Anatomy
2. Langman , Jan : Medical Embryology
3. Module of Embryonic phase : The Carnegie Stages
4. Terminologia anatomica : Federative International Programme on
Anatomical Terminologies(FIPAT),2nd edit,Georg Thieme Verlag
5. UNSW : Embryology
6. Pictures :
5.1. smartmomz.com
5.2. web.duke.edu
5.3. www.dmacc.edu
5.4. www.dreamstime.com
5.5. www.embryo.chronolab.com
5.6. www.nature.com
5.7. www.nlm.nih.gov
5.8. www.studyblue.com
5.9. www.uptomed.ir
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