Stevia has anti-diabetic properties

and compares favorably with the

drug glibenclamide but without the
adverse effects. - GreenMedInfo Summary
Abstract Title:
Antidiabetic activity of medium-polar extract from the leaves of Stevia rebaudiana Bert.
(Bertoni) on alloxan-induced diabetic rats.

Abstract Source:
J Pharm Bioallied Sci. 2011 Apr ;3(2):242-8. PMID: 21687353

Abstract Author(s):
Himanshu Misra, Manish Soni, Narendra Silawat, Darshana Mehta, B K Mehta, D C Jain

Article Affiliation:
School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain - 456 010,
Madhya Pradesh, India.

Abstract:
OBJECTIVE: To investigate the medicative effects of medium-polar (benzene:acetone, 1:1,
v/v) extract of leaves from Stevia rebaudiana (family Asteraceae) on alloxan-induced
diabetic rats.

MATERIALS AND METHODS: Diabetes was induced in adult albino Wistar rats by
intraperitoneal (i.p.) injection of alloxan (180 mg/kg). Medium-polar extract was
administered orally at daily dose of 200 and 400 mg/kg body wt. basis for 10 days. The
control group received normal saline (0.9%) for the same duration. Glibenclamide was
used as positive control reference drug against Stevia extract.

RESULTS: Medium-polar leaf extract of S. rebaudiana (200 and 400 mg/kg) produced a
delayed but significant (P<0.01) decrease in the blood glucose level, without producing
condition of hypoglycemia after treatment, together with lesser loss in the body weight
as compared with standard positive control drug glibenclamide.

CONCLUSIONS: Treatment of diabetes with sulfonylurea drugs (glibenclamide) causes

hypoglycemia followed by greater reduction in body weight, which are the most
worrisome effects of these drugs. Stevia extract was found to antagonize the necrotic
action of alloxan and thus had a re-vitalizing effect on-cells of pancreas.

Article Published Date : Apr 01, 2011

Study Type : Animal Study
Additional Links
Substances : Stevia : CK(64) : AC(25)
Diseases : Diabetes Mellitus: Type 1 : CK(1130) : AC(301)
Pharmacological Actions : Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Beta Cell Regeneration : CK(78) : AC(29), Superiority of Natural
Substances versus Drugs : CK(1316) : AC(251)
Problem Substances : Glibenclamide : CK(122) : AC(3)
Adverse Pharmacological Actions : Hypoglycemic : CK(12) : AC(2)