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Dear all,
Congrats for your GATE Result. Now, concentrate on your admission process
& carrying out admission process smoothly is as important as scoring good rank
in GATE.
Dear friends,
We have not seen many institutes but of the much we have seen and the much
we have heard, NIPER is amongst the best. We are sure most of you would be
aspiring of being in NIPER. Those who are sure of their capability and
competence should prove their worth. Those who are determined will find their
way at their own but if there is a helping hand, probability of success is higher.
So this is a small attempt to help those aspiring for a career in pharmaceutical
research at NIPER.
Here is a compilation of certain important points for each subject to be noted.
These are just grids for the study and are helpful for the exam. By the way most
of these are covered in B. Pharm syllabus. For the paper, our experience is that
one should revise the GATE syllabus and should
have grip on the FUNDAMENTALS (M.SC-SUBJECTS-ORGANIC
CHEMISTRY,ANALYSIS,BIOCHEMISTRY,MICROBIOLOGY,BIO-
TECHNOLOGY,M.B.A-MANAGEMENT RELATED ,LOGICAL). Most
of the questions in paper are quite easy. But be sure you are well prepared for it.
What to study???
The below mentioned topics are most frequently touched topics in last 5 yrs
March 16, 2009
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
REFERENCES:
JERRY MARCH +MORRISON AND BOYD+ I. L. FINAR
V.K.KAPOOR
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
REFERENCES:
REMINGTON’S PHARMACEUTICAL SCIENCES+
LACHMANN+
ALFRED MARTIN+SUBRAHMANYAM
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
NATURAL PRODUCTS:
In natural products more stress should be given on phytochemistry part rather
than pharmacognosy aspects but you should know about
biological sources and chemical constituents
1. Methods of extraction, isolation and characterization of natural products.
Various
separation techniques used for isolation of natural products.
2. Biosynthetic pathways.
3. Primary metabolites, their examples.
4. Secondary metabolites, various classes of secondary metabolites (eg.
Alkaloids, glycosides, tannins, lignans, saponins, lipids, flavonoids, coumarins,
etc.). Here most imp. part is chemistry of these classes.
5. Important therapeutic classes: antidiabetics, hepatoprotectives,
immmunomodulators, neutraceuticals, natural products for gynaecological
disorders, anti-cancer, anti-viral
(mainly anti-HIV), adaptogens etc.
6. Dietary antioxidants, Marine natural products, Plant growth regulators.
7. Fischer projection formulas.
8. Biological sources of important classes of natural products. (Selected ones
only)
9. Standardization of natural products, analytical pharmacognosy.
10. What is difference between natural products and pharmacognosy ?
11. Some knowledge about types and preparation of ayurvedic formulatios like
asava, arista etc.
REFERENCES: TREASE AND EVANS+ KOKATE�
March 16, 2009
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
PHARMACEUTICAL ANALYSIS:
1. Stability testing of pharmaceuticals, various stability tests, kinetic studies,
shelf life determination, thermal stability, formulation stability.
2. Various analytical techniques
3. Tests: physical and chemical tests, limit tests, microbiological tests,
biological tests, disintegration and dissolution tests.
4. Thermal techniques: DSC, DTA, TGA, etc.
5. Chromatography- detailed.
6. QA and QC: GLP, TQM, ISO system.
7. Solubility: pH, pka, surfactant HLB values, Rheology. (IMP)
8. Crystallinity, polymorphism, solvates and hydrates, crystal habits, porosity,
surface area flow properties.
9. Dosage forms, Stages of dosage form development
10. Osmolality, osmolarity, osmotic pressure, conductivity
REFERENCES-VOGEL,PAVIA,WILLARD,SKOOG,KASTURE
�BIOTECHNOLOGY
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
PRACTICE OF PHARMACY:
Adverse Drug Reactions,
Rational drug use as well as some typical case studies in diabetes and
hypertension and
some case study regarding cvs and antiinffective. Therapeutic drug monitoring
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
Hospital pharmacy
Clinical pharmacy
* You should give attention to statistics in which mean, median, mode, anova,
paired test.
*Pharmacy Act and D&C act. and knowledge about important laboratories of
India and
there location.
VERY FREQUENTLY ASKED QUESTION:
_Polarity of solvents for chromatography
_ Rf values for better separation.
_ Absorbent in reverse phase chromatography
_ Partition coefficient between liquid-liquid phase
_ Naming of peptides (i.e. pentapeptide, hexapeptide)
_ Hetero and homo diens
_ Setro of biphenyl,cyclohexane(conformations)
_ Haemllet equation and saturation kinetics
_ IR frequency of carbonyl compounds
_ Solvents for IR and NMR
_ Mechanism of action of barbiturates, pyrimethamine, co trimoxazole
_ Technique for separation of isomers and racemic mixture.
_ Applications of spectroscopic technique
_ Gas laws (boyle charles etc)
_ Polymers in pharmaceutics.
_ Calculation for J value (NMR)
_ Isomers of important phytopharmaceuticals and its use.
_ Alpha carotene contains how many rings
_ Squalene contains how many isoprene units
_ Use of each 5 HT receptors
_ Measurement of flow properties and its importance
_ Role of excipients and stage of addition of each
_ Solvents for oral use, iv use and reconstitution
_ All IP standards for tablets and capsules
_ Accelerated stability testing
_ Applications of various mixers and dryers
March 16, 2009
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.
SHIVANG CHAUDHARY
March 16, 2009 E MAIL ID- shivang47@gmail.com /MOBILE-9904474045
SHIVANG CHAUDHARY
B.PHARMA (NIRMA INSTITUTE OF PHARMACY)
M.S.PHARMA (PHARMACEUTICS)-NIPER-A.