416 SEC TION III HEMATOLOGY AND ONCOLOGY `

HEMATOLOGY AND ONCOLOGYPHARMACOLOGY

Cancer drugscell cycle

Bleomycin Microtubule inhibitors

Paclitaxel
Vinblastine
Vincristine
G2 Mit M
os
Double check is
repair

is
nes
oki
Cy t
Topoisomerase inhibitors
Etoposide

INT
Teniposide RP

E
Irinotecan HASE
Duplicate
Topotecan DNA cellular content
synthesis Cell cycleindependent drugs
G1 Platinum agents (eg, cisplatin)
Antimetabolites GO Alkylating agents:
Azathioprine S Resting Busulfan
Cladribine Cyclophosphamide
Cytarabine Ifosfamide
5-uorouracil Rb, p53 modulate Nitrosoureas (eg, carmustine)
Hydroxyurea G1 restriction point
Methotrexate
6-mercaptopurine

Cancer drugstargets
Nucleotide synthesis DNA RNA Protein Cellular division

MTX, 5-FU: Vinca alkaloids:

Alkylating agents, platinum agents:
thymidine synthesis inhibit microtubule formation
cross-link DNA

6-MP: Paclitaxel:
Bleomycin:
de novo purine synthesis inhibits microtubule disassembly
DNA strand breakage

Hydroxyurea: Dactinomycin, doxorubicin:

inhibits ribonucleotide DNA intercalators
reductase
Etoposide/teniposide:
inhibits topoisomerase II

Irinotecan/topotecan:
inhibits topoisomerase I