Pathophysiology of Cervical Cancer

High risk HPV (16, 18, 31) Risk factors:

Early age of coitus
Multiple sexual partners
Unsafe sexual practices
 Invasion of the basal cell
of the squamous
epithelium of the cervix

Integration of viral DNA

p53 and pRB tumor

suppressor genes are Barrel-shaped
blocked/deactivated cervix

Mutation and cell

proliferation

CIN/SIL Tumor fills the entire

Co- Carcinoma in situ cervix
carcinogens

Metastasis to distant body

parts Invasive cancer Tissue necrosis and
sloughing
Increased tumor growth
Lymph invasion
Hypermetabolic Increased pressure to Fistula formation Hemorrhage Infection
activity of cell the surrounding Enlargement of
proliferation and tissues, nerves and lymph nodes
increased tumor bladder
growth needs Leakage of
urine and Metrorrhag Foul-
Venous and feces into ia smelling
Dysuria Ureteral the vagina Bleeding vaginal
Pelvic
obstruction after discharge
Anorexia and
coitus
Weight back
anemia
loss pain
Hydronephrosi Leg edema
s