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Volume Therapy
Gelofusine
Worldwide tried and tested Efficient and reliable volume effect when compared
Gelofusine is a colloidal volume replacement fluid based on to modern HES 130
4% modified fluid gelatin. Due to the special molecular structure with negative charges
on the surface, Gelofusine results in an efficient and reliable
Several decades of experience in production and use of modified volume effect when compared to modern HES 130 products:
fluid gelatins recommend B. Braun as the partner of choice in Over the 6 hours following infusion, the magnitude and duration
the field of volume therapy. of the volume effect of 4% modified fluid gelatin was similar
compared to Voluven and significantly greater than volume
Over the years, B. Braun has put together an impressive track effect produced by 0.9% NaCl in healthy volunteers (Fig. 2)1.
record with Gelofusine with proven pharmaceutical quality
and demonstrated therapeutical value. Due to its stretched polypeptide chains and the negative charge,
retention of Gelofusine in the circulation is prolonged.
Important advantages in comparison with other gelatins make Like albumin, Gelofusine is repelled by negatively charged cap-
Gelofusine the most often used gelatin for modern volume illary endothelium and provide a colloid osmotic pressure (COP)
therapy. that is comparable with albumin for effective treatment of
hypovolemia (Fig. 3)3.
[ml] 700
Gelofusine (G) 4%
modified fluid gelatin
600
Change in blood volume
400
300 0.2
200
0.1
100
0 0
0 1 2 3 4 5 6 Urea-linked Human Gelofusine
Time [hours] Gelatin Albumin
Fig. 2: Changes in blood volume and extravascular fluid volume after infusion of Fig. 3: COP50 /COP10 ratios (as indicator for plasma retention). Adapted from3. .
5
1 litre of 0.9% saline (S), 4% modified fluid gelatin (G) and 6% HES 130 (V)
over 1 hour 1.
1. Lobo DN:
Effect of volume loading with 1 liter intravenous infusions of 0.9% 4. Wilkes N J et al.:
saline, 4% succinylated gelatine (Gelofusine) and 6% hydroxyethyl starch The effects of balanced versus saline-based hetastarch and crystalloid
(Voluven) on blood volume and endocrine responses: a randomized, three-way solutions on acid-base and electrolyte status and gastric mucosal perfusion
crossover study in healthy volunteers. in elderly surgical patients
Crit Care Med. 2010 Feb; 38(2): 464-70 Anesth Analg 93 (2001) 811-816