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23 February 2017 07:20
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23 February 2017 ProQuest

 Daftar isi

1. Open Fractures; Findings from R. Otchwemah and Co-Authors Broaden Understanding of Open
Fractures (Bacterial contamination of open fractures - pathogens, antibiotic resistances and therapeutic
regimes in four hospitals of the trauma network Cologne, Germany)............................................................. 1

23 February 2017 ii ProQuest

Dokumen 1 dari 1

Open Fractures; Findings from R. Otchwemah and Co-Authors Broaden Understanding of Open
Fractures (Bacterial contamination of open fractures - pathogens, antibiotic resistances and
therapeutic regimes in four hospitals of the trauma network Cologne, Germany)
Link dokumen ProQuest

Abstrak:
Our news journalists obtained a quote from the research, "In this work, our aims were to characterize the
bacterial spectrum present in open fractures, analyze the bacterial resistance to antibiotic agents and question
the EAST guideline recommendations for antibiotic prophylaxis after open fractures in a German Trauma
Network. We conducted a retrospective cohort study and included all patients with open fractures from 1st of
January 2011 until the 31st of December 2014 in four hospitals of the trauma network cologne. Soft tissue
damage was classified according to the Gustilo Anderson classification. We included 123 patients. Forty-five
injuries (37%) were classified I degrees, 45 (37%) as II degrees and 33 (27%) as III degrees. Lower leg (34%)
was the most commonly injured location. An antibiotic prophylaxis was administered to 109 patients (89%). In
107 of them (98%) a cephalosporin or cephalosporin combination was given. In 35 of the patients (28%),
microbiological samples were taken of the fracture site. Wound cultures were positive in 21 patients (60%). Fifty
percent of the bacterial detections occurred in III degrees fractures. Coagulase negative Staphylococci (COST)
were the most frequent pathogens.

Teks lengkap:
2015 DEC 5 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness &Wellness Week -- Current
study results on Open Fractures have been published. According to news reporting out of Cologne, Germany,
by NewsRx editors, research stated, "The bacterial contamination of soft tissues and bone in open fractures
leads to an infection rate of up to 50%. Pathogens and their resistance against therapeutic agents change with
time and vary in different regions."
Our news journalists obtained a quote from the research, "In this work, our aims were to characterize the
bacterial spectrum present in open fractures, analyze the bacterial resistance to antibiotic agents and question
the EAST guideline recommendations for antibiotic prophylaxis after open fractures in a German Trauma
Network. We conducted a retrospective cohort study and included all patients with open fractures from 1st of
January 2011 until the 31st of December 2014 in four hospitals of the trauma network cologne. Soft tissue
damage was classified according to the Gustilo Anderson classification. We included 123 patients. Forty-five
injuries (37%) were classified I degrees, 45 (37%) as II degrees and 33 (27%) as III degrees. Lower leg (34%)
was the most commonly injured location. An antibiotic prophylaxis was administered to 109 patients (89%). In
107 of them (98%) a cephalosporin or cephalosporin combination was given. In 35 of the patients (28%),
microbiological samples were taken of the fracture site. Wound cultures were positive in 21 patients (60%). Fifty
percent of the bacterial detections occurred in III degrees fractures. Coagulase negative Staphylococci (COST)
were the most frequent pathogens. In II degrees open fractures one gram-negative strain was isolated. Fewest
resistances were seen against quinolones and co-trimoxazole. The recommended EAST guideline prophylaxis
would have covered all but one bacterium (97% of positive cultures). One Escherichia coli was found in a II
degrees open fracture and would have been missed. One of the isolated Staphylococci epidermidis and an
Enterococcus faecium were resistant against gentamycin and first- and second- generation-cephalosporin's
which were used as prophylaxis frequently. However, a regional adaption of the EAST guidelines seems not
justified due to the rather low number of cases in our study. The EAST guideline seems to be adequate in a
high percentage of cases (97%) in the setting of the trauma network cologne."
According to the news editors, the research concluded: "Further research should be guided at identification of

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initial open fracture pathogens to improve the efficiency of antibiotic prophylaxis."
For more information on this research see: Bacterial contamination of open fractures - pathogens, antibiotic
resistances and therapeutic regimes in four hospitals of the trauma network Cologne, Germany. Injury-
International Journal of the Care of the Injured, 2015;46():S104-S108. Injury-International Journal of the Care of
the Injured can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB,
Oxon, England.
Our news journalists report that additional information may be obtained by contacting R. Otchwemah, Cologne
Merheim Med Center, Inst Hyg, D-51109 Cologne, Germany. Additional authors for this research include V.
Grams, T. Tjardes, S. Shafizadeh, H. Bathis, M. Maegele, F. Mattner, S. Messler, B. Bouillon and C. Probst.
Keywords for this news article include: Antibacterial, Antibiotic Prophylaxis, Antimicrobials, Europe, Cologne,
Germany, Therapy, Hospital, Premedication, Open Fractures, Chemoprevention, Bacterial Infections and
Mycoses
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2015,
NewsRx LLC

Pengidentifikasi/kata kunci: Cologne Germany Europe Antibacterial Antibiotic Prophylaxis Antibiotics

Antimicrobials Bacterial Infections and Mycoses Chemoprevention Hospital Open Fractures Premedication
Therapy

Judul: Open Fractures; Findings from R. Otchwemah and Co-Authors Broaden Understanding of Open
Fractures (Bacterial contamination of open fractures - pathogens, antibiotic resistances and therapeutic regimes
in four hospitals of the trauma network Cologne, Germany)

Judul publikasi: Obesity, Fitness & Wellness Week; Atlanta

Halaman pertama: 400

Tahun publikasi: 2015

Tanggal publikasi: Dec 5, 2015

Tahun: 2015

Penerbit: NewsRx

Tempat publikasi: Atlanta

Negara publikasi: United States

Subjek publikasi: Medical Sciences

ISSN: 15316386

Jenis sumber: Trade Journals

Bahasa publikasi: English

Jenis dokumen: Expanded Reporting

ID dokumen ProQuest: 1735957349

URL Dokumen: https://search.proquest.com/docview/1735957349?accountid=25704

Hak cipta: Copyright 2015, NewsRx LLC

Terakhir diperbarui: 2015-11-25

Basis data: Public Health Database

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