Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
E-Journal of Chemistry
http://www.e-journals.net 2009, 6(1), 89-92
*
Department of Pharmaceutical Sciences,
Dr. H.S. Gour Vishwavidyalaya, Sagar (M.P.), India.
#
IPS College of Pharmacy, Gwalior (M.P.), India.
GLA Institute of Pharmaceutical Research, Mathura-(U.P.), India.
alka0207@gmail.com
Introduction
Rosuvastatin calcium (ROSU) is chemically bis [(E)-7 [4-(4-fluorophenyl)-6 isopropyl- 2-
[methyl (methyl-sulphonyl) amino] pyrimidin-5-yl] (3R, 5S) -3,5-dihydroxyhept-6-enoic
acid] Calcium salt. It is a lipid-lowering drug1-2. It inhibits the enzyme 3-hydroxy-3-methyl
glutaryl coenzyme A (HMG-CoA) reductase, the rate limiting enzyme that converts HMG-
CoA to mevalonate a precursor of cholesterol and thereby checks the synthesis of
cholesterol. It is used in the treatment of hyper-cholesterolemia and dyslipidemia3-4. A
survey of literature5,6 showed few solid phase extraction using tandem MS, few LC-MS
methods7-9 and one HPTLC method10 for the estimation of ROSU in pharmaceutical
preparations and in biological fluids.
90 ALKA GUPTA et al.
Rosuvastatin
Figure 1. Rosuvastatin scanned in UV range (in Methanol).
Simple UV Spectrophotometric Determination of Rosuvastatin Calcium 91
International Journal of
Carbohydrate Journal of
Chemistry
Hindawi Publishing Corporation
Quantum Chemistry
Hindawi Publishing Corporation
http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014
Journal of
The Scientific Analytical Methods
World Journal
Hindawi Publishing Corporation
in Chemistry
Hindawi Publishing Corporation
http://www.hindawi.com Volume 2014 http://www.hindawi.com Volume 2014