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Course No: MGGC2107 University of Palestine Instructor Name: Dr.

Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

Read instruction and questions carefully before answering.

I. MCQs: Select only one answer. (35 marks)

1. Fungi reproduce by:


A Spore formation B Bud formation
C Binary fission D Host cell synthesis of bacterial
components
E A & B are correct

2. Lipopolysaccharide are correctly described as:


A Found in gram-negative B Able to produce a febrile response
bacteria of all species
C Possessing somatic antigen D Containing lipid A as an integral part of
specificity their structure
E All of the above

3. Bacteria H antigen is derived from:


A Microtubule B Hemolysin
C Pillin D Flagellin
E Endotoxin

4. The endotxin of gram-negative bacteria is associated with :


A Mesosome B Cytoplasmic membrane
C Capsule D Cell wall
E Pilus

5. The most common stain used in the clinical microbiology laboratory for detecting the
presence of bacteria and assessing the quality of specimens is the:
A Auramine-rhodamine stain B Grams stain
C Silver stain D Ziehl-neelsen stain
E Giemsas stain

6. In the Grams stain, forgotten the decolorization step will make the gram-negative bacteria
to appear:
A Blue in color B Red in color
C Colorless D Green in color
E None of the above

7. Two hundred and fifty colonies were counted on a plate on which 0.1 mL of 10-3 dilution of
a urine sample was inoculated. The number of bacteria per 1 mL of the urine is:
A 2.5 x 105 B 25 X 105
C 2.5 X 106 D 2.5 X 107
4
E 25 X 10

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

8. A gram-positive coccus that grows in pairs or short chains and that is alpha-hemolytic and
optochin-sensitive is:
A Streptococcus pyogenes B Neisseria meningitidis
C Staphylococcus epidermidis D Staphylococcus aureus
E Streptococcus pneumonia

9. Most organisms that cause urinary tract infection come from:


A Toilet seats B Normal bowel flora
C Sexual partners D The environment
E Normal skin flora

10. Characteristics of the genus Neisseria include all of the following EXCEPT they are:
A Cocci B Gram-negative
C Oxidase-negative D Not acid-fast
E Found only in humans

11. The primary site of infection with Entamoeba histolytica in humans is the:
A Skin B Duodenum
C Cecum and colon D Liver
E pericardium

12. All of the following bacterial agents can cause dental carries EXCEPT:
A Streptococcus mutans B Lactobacillus species
C Actinomyces species D Veillonella species
E None of the above

13. The most effective anti-plaque agent is:


A Chlorhexidine B Sodium lauryl sulphate
C Tetrahydropholate D Sodium fluoride
E All of the above

14. All of the following factors may prevent penetration of intact oral mucosa by micro-
organisms EXCEPT:
A Saliva B Keratin
C Granular layer D Basement membrane
E None of the above

15. Lactoferrin that present in saliva and working as antimicrobial agent is described as:
A Heat stable protein, bacteriostatic to B Heat labile protein, bacteriostatic to
many microorganisms many microorganisms
C Heat stable antibacterial enzyme D Heat labile antibacterial enzyme
E Bactericidal by splitting the cell
wall

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

16. This form the major proportion of bacteria found in the dental plaque, especially at a
proximal sites:
A Staphylococci spp. B Streptococci spp.
C Actinomyces spp. D Lactobacilli spp.
E Neisseria spp.
17. Factors affecting the growth of oral micro-organisms include all of the following
EXCEPT:
A The diet B Host defences
C Salivary components D Hydrogen tension
E None of the above

18. This hepatitis virus do not pose a major cross-infection hazard in dentistry:
A HBV B HAV
C HGV D HDV
E HCV

19. Which one of the following outcomes is MOST common following a primary herpes
simplex virus infection?
A Complete eradication of virus B Persistent asymptomatic viremia
and virus-infected cells
C Establishment of latent infection D Persistent cytopathic effect in infected cells
E None of the above

20. Each of the following viral pathogens is likely to establish chronic or latent infection
EXCEPT:
A Cytomegalovirus B Hepatitis A
C Hepatitis B D Herpes simplex virus
E Human Immunodeficiency
Virus (HIV)

21.Herpes simplex virus and cytomegalovirus share many features. Which one of the
following features is LEAST likely to be shared?
A Important cause of morbidity B Important cause of serious disease in
and mortality in the newborn immunosuppressed individuals
C Mild or Inapparent infection D Congenital abnormalities due to
transplacental passage

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

22. Each of the following statements concerning hepatitis C virus (HCV) and hepatitis D virus
(HDV) is correct EXCEPT:
A HCV is an important cause of B Delta virus is a defective virus with an
post-transfusion hepatitis RNA genome and a capsid composed of
HBsAg
C HDV is transmitted primarily by D People infected with HCV commonly
body fluids as blood become chronic carriers and are in risk to
develop hepatocellular carcinoma
E None of the above

23. Each of the following statements concerning hepatitis A virus is correct EXCEPT:
A The initial site of viral replication B Hepatitis A virus commonly causes
is the gastrointestinal tract asymptomatic infection in children
C The diagnosis is usually made by D Gamma globulin is used to prevent the
isolating the virus in cell culture disease in exposed persons

24. Each of the following statements concerning human immunodeficiency virus is correct
EXCEPT:
A The western blot test is more B Transmission of HIV occurs primarily by
specific for HIV infection than the the transfer of blood or semen in adults
ELISA is
C The CD4 protein on the T-cell D There is appreciable antigenic diversity
surface is the receptor for the virus in the envelope glycoprotein of the virus
E None of the above

25. This virus causes infectious mononucleosis?


A Epstein-Barr virus (EBV) B Cytomegalovirus (CMV)
C Rhinovirus D Adenovirus
E Parainfluenza virus

26. Neutrophils are attracted to an infected area by:


A IgM B C1 (complement)
C C5a (complement) D C8 (complement)
E Interferon

27. A primary immune response in an adult human requires approximately how much time to
produce detectable antibody levels in the blood?
A 12 hours B 3 days
C 3 weeks D 1 week
E 2 months

28. This immunoglobulin contains 10 heavy chain and 10 light chains:


A IgM B IgG
C IgD D IgA
E IgE
4/9
Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

29. Complement can enhance phagocytosis because of the presence on macrophages and
neutrophils of receptors for:
A Factor D B C3b
C TNF D Interferon
E Histamine

30. Artificially acquired active immunity:


A Resulting from infection B Acquired trancplacentaly or via
colostrums
C Vaccination D Injection of antibody
E All of the above

31. All of the followings are characteristics of IgE antibody EXCEPT:


A Monomer B Has receptor on red blood cells and
neutrophils
C Present in allergic reaction D Causes lysis of parasitic worms
E None of the above

32. All of the followings are capsular polysaccharide vaccines EXCEPT:


A Streptococcus pneumonia B Haemophilus influenza
C Salmonella typhi D Bordetella pertussis
E Neisseria meningitis

33. Which of the followings is live, attenuated bacterial vaccines ?


A Vibrio cholerae B Clostridium tetani
C M. tuberculosis D Bacillus anthracis
E Yersinia pestis

34. All of the followings are inhibitors of cell wall synthesis EXCEPT:
A Penicillin B Cephalosporin
C Vancomycin D Bacitracin
E Chloramphenicol

35. All of the following diseases can be transmitted via contaminated water or food EXCEPT:
A Shigellosis B Typhoid fever
C Cholera D Mumps
E Amoebic dysentry

II. Give the causative agent for the following diseases? (10 marks)
Disease Causative agent
Whooping cough
Tuberculosis

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

Pneumococcal pneumonia
Carbuncle
Impetigo
Syphilis
Gonorrhoea
Nongonococcal urethritis
Acne
Otitis externa
Subcutaneous mycoses
Chancroid (Soft Chancre)
Pyelonephritis
Hydatid Disease
Aflatoxins
Otitis media
Peptic ulcer
Scarlet Fever
Psittacosis
Viral pneumonia

III. Define the following terms (10 marks)


1. Probiotics:

2. Antiseptic agent:

3. Pasteurization:

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

4. Erysipelas:

5. Molluscum contagiosum:

6. STD:

7. Hapten:

8. ETEC:

9. Atypical pneumonia:

10. BCG:

7/9
Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

IV Assay questions (15 marks)

1. Compare between the microbial diseases of the upper respiratory system and lower
respiratory system with examples?

2. Enumerate the different actions of antimicrobial drugs with examples?

3. How you can differentiate between Streptococcus pneumonia and viridans Streptococci?

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Course No: MGGC2107 University of Palestine Instructor Name: Dr. Nahedh Al Laham
Course Title: Medical Microbiology Student No.: _________________
Date: 02/02/2009 Student Name: _______________
No. of Questions:(4) Final Exam College Name: _______________
Time: 2hours nd
1 semester 2008/2009 Dep. / Specialist: ______________
Using Calculator (No) Total Grade:(70) Using Dictionary (No)

4. Hypersensitivity reactions?

5. Just enumerate antibiotic susceptibility tests?

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