Skelan Omnibus DA detailing script

Good day doctor,

Today I would like to talk to you about

the threat of arthritis and what you can
do to safeguard your patients against a
lifetime of disability.

Luckily, we have strong allies on our

side in the form of Skelan Joint Forces:
Skelan, Skelan Protect and our new
secret weapon, Skelan Joint-Max
1500.

Through Skelan Joint Forces, we now

have the power to combat arthritis!

We must not underestimate the enemy,

osteoarthritis AKA OA. OA is a
formidable threat.

Did you know that osteoarthritis is the

highest ranking musculoskeletal
disease worldwide?

When we think of osteoarthritis, knee

pain often comes to mind. It is no
surprise that knee OA is estimated to
be the 4th and 8th most important cause
of disability in women and men,
respectively. In the Philippines,
osteoarthritis greatly impacts patients
well-being and quality of life.

If we are to win this fight, we must

provide comprehensive and holistic
care to our patients.

Doctor, I would like to share with you a

new secret weapon against
osteoarthritis known as glucosamine.
Because of its special properties, we
believe that glucosamine is the special
forces unit in the fight against
osteoarthritis.
Our new product, Skelan Join-Max
1500 is made from glucosamine
sulfate. Skelan Joint-Max 1500 will
truly give your patients the Power to
Endure Over Arthritis. Why?

One, because Skelan Joint-Max 1500

has both anti-inflammatory and
structure-modifying effects on joints
that help delay osteoarthritis
progression.

Two, Skelan Joint-Max 1500 reduces

knee OA pain and improves joint
function.

Three, Skelan Joint-Max 1500 may

delay osteoarthritis progression,
helping patients maintain function and
remain active longer.

Glucosamine stands out from the rest

because of its dual action, especially
for knee osteoarthritis:

As a disease-modifying agent,
glucosamine has been shown to
provide as much as a 54% reduction in
the 3-year progression of joint space
narrowing, an indicator of OA
progression.

As a symptom-modifying agent,
glucosamine minimizes long-term joint
pain and stiffness and improves joint
function.

But not all forms of glucosamine are

equal. We stand by our new product,
Skelan Joint-Max 1500 and heres
why...
Skelan Joint-Max 1500 is made from
glucosamine sulfate that is more
effective than glucosamine
hydrochloride found in other
supplements.

This is because the sulfate anion may

itself promote chondoitin sulfate
synthesis that is vital for proteoglycan
and cartilage production.

Skelan Joint-Max 1500 has a

comparable action to the competing
brand.

This table shows the effect of Skelan

Joint-Max 1500 and the competing
brand on the release of nitric oxide
from macrophages.

Nitric oxide is a substance that is

implicated in causing osteoarthritis
progression. In the lab, we can
replicate the release of nitric oxide
from macrophages by adding
lipopolysaccharides (LPS). The first
red bar shows how much nitric oxide is
released when LPS is added.

We see that as we increase the

amount of Skelan Joint-Max (light
green bars), there is less concentration
or amounts of released nitric oxide.
The strength of Skelan Joint-Max (light
green bars) in lowering nitric oxide
release is very similar to Brand V
(purple bars). At higher doses, the
amount of nitric oxide is the same as
when LPS was not added to the
macrophages (second red bar).
Skelan Joint-Max has an economical
advantage over the competing brand. It
costs 42% less per 1,500 mg sachet.
This is very important because
glucosamine works best when used
continuously. At just P45 per day,
Skelan Joint-Max 1500 is very
affordable and amounts to hundreds of
pesos worth of savings.

Doctor, as you know, NSAIDs are

useful in giving symptomatic relief for
patients with osteoarthritis. But the
appropriate choice of NSAID must be
guided by the gastrointestinal and
cardiovascular risks of the patient.

This chart summarizes the approach to

symptomatic OA treatment. As you can
see, naproxen plus a proton pump
inhibitor is the preferred choice for
patients with a high cardiovascular risk.

I would like to present you with the

Stars of Skelan, your other allies in the
battle against arthritis:

Skelan is naproxen sodium, an NSAID

that can combat osteoarthritis pain.

For patients with a high GI risk, we

recommend Skelan Protect, a
combination of naproxen sodium and
omeprazole that offers a combined
defense against arthritis and NSAID-
induced gastritis.
So doctor, I urge you to join forces with
Skelan Joint Forces and give all your
patients the power they need to
combat arthritis. Remember your
powerful allies: Skelan, Skelan Protect
and of course, Skelan Joint-Max 1500.

Last but not least, let us not forget that

non-pharmacologic interventions are
just as important to combat arthritis
and work hand-in-hand with medical
treatment. These are the SWAT team
which includes:

Promoting patient Self-care and

education,
Initiating appropriate Weight loss
measures for patients who are
overweight,
Encouraging physical Activity and
exercise,
And using other non-pharmacologic
Therapies such as acupuncture or
transcutaneous electrical nerve
stimulation (TENS).

Thank you, for your time. We hope you

can join us win the war against our
sworn enemy known as arthritis!