Jasplakinolide, Jaspis johnstoni Size

Cat. No. 420107 50 g

Description: A cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide,

isolated from the marine sponge Jaspis johnstoni, is a potent inducer of
actin polymerization and stabilization in vitro. It competes with Phalloidin
(Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances
apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays
fungicidal, insecticidal, and anticancer properties.

Form: Yellow solid. Packaged under an inert gas.

CAS Number: 102396-24-7

Molecular Weight: 709.7

Molecular Formula: C36H45BrN4O6

HO
Structure: Br
H
N

H
N CH3
N
O CH3
O O O
O NH
H3 C H3C

H3C CH3

Purity: 95% by HPLC

Solubility: DMSO or warm methanol (0.5 mg/ml).

Storage: Freezer (-20C). Protect from light. This product is stable for 2 years as
supplied.

Toxicity: MSDS available upon request.

References: Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.

Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.

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E-mail address for technical inquiries: technical@calbiochem.com
Find our current product data sheets on the web: http://www.calbiochem.com

Revised: 14-May-01

 CN: 420107

Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

FOR RESEARCH USE ONLY. NOT FOR HUMAN OR DRUG USE.