28/11/2016 ExerciseTreatmentforMajorDepression:MaintenanceofTher...

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PsychosomaticMedicine:
September/October2000Volume62Issue5pp633638
OriginalArticles

Exercise Treatment for Major Depression: Maintenance of Therapeutic Benefit at 10 Months

Babyak,MichaelPhDBlumenthal,JamesA.PhDHerman,StevePhDKhatri,ParindaPhDDoraiswamy,MuraliMDMoore,KathleenPhDEdwardCraighead,W.
PhDBaldewicz,TeriT.PhD,andRangaKrishnan,K.MD

Abstract

Objective:Thepurposeofthisstudywastoassessthestatusof156adultvolunteerswithmajor
depressivedisorder(MDD)6monthsaftercompletionofastudyinwhichtheywererandomly
assignedtoa4monthcourseofaerobiceercise,sertralinetherapy,oracombinationofe
erciseandsertraline.
Methods:Thepresenceandseverityofdepressionwereassessedbyclinicalinterviewusing
theDiagnosticInterviewScheduleandtheHamiltonRatingScaleforDepression(HRSD)and
byselfreportusingtheBeckDepressionInventory.Assessmentswereperformedatbaseline,
after4monthsoftreatment,and6monthsaftertreatmentwasconcluded(ie,after10
months).
Results:After4monthspatientsinallthreegroupsehibitedsignificantimprovementthe
proportionofremittedparticipants(ie,thosewhonolongermetdiagnosticcriteriaforMDD
andhadanHRSDscore<8)wascomparableacrossthethreetreatmentconditions.After10
months,however,remittedsubjectsintheeercisegrouphadsignificantlylowerrelapserates
(p=.01)thansubjectsinthemedicationgroup.Exercisingononesownduringthefollowup
periodwasassociatedwithareducedprobabilityofdepressiondiagnosisattheendofthat
period(oddsratio=0.49,p=.0009).
Conclusions:AmongindividualswithMDD,eercisetherapyisfeasibleandisassociatedwith
significanttherapeuticbenefit,especiallyifeerciseiscontinuedovertime.

Copyright2000byAmericanPsychosomaticSociety

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