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Altered Repolarization
of the Myocardium

Release of Lysosomal
Enzymes

Anaerobic Lactic Acid

Glycolysis Production

Myocardial
Irritability
Decreased ANGIN
Contractility A
DYSRHYTHMI
A

Ventricular
Function

Preload CO

Blood Flow
to Brain

LOSS OF
CONS-
CIOUSNESS

3
 Enlargement of www.NursesLabs.com
Thrombus

Occlusive
WEAKNESS/FATIGUE (JULY 17- Thrombus
19)
Ischemia of Tissue in
PALPITATIONS
Region Supplied by
Artery
O2
Coronary Blood Supply
Less Than Demand

CO2
levels MYOCARDIAL CELL DEATH
(NECROSIS)
Bld
pH

DEEP & Stimulation of

LABORED Sympathetic NS
BREATHIN
G

O2
HR
need Afterload

Vasoconstrictio
Epinephrine n
&
Norepinephrin
e Production HTN
BMR

ARRHYTHMI Blood Supply

A to GI Tract

DIAPHORESI N/V
S

2
 PATHOPHYSIOLOGY OF ACUTE MI (BOOK-
BASED) www.NursesLabs.com
ACUTE MYOCARDIAL INFARCTION
.

MODIFIABLE FACTORS: NONMODIFIABLE

FACTORS:
Hypertension
Smoking (+) Family Hx of AMI
levels of triglyceride, total cholesterol & Aging
LDL Men and
DM Postmenopausal
Obesity Women
Excessive intake of saturated fats,
carbohydrates or salt
Sedentary lifestyle/physical inactivity
Stress/Type A personality
Drug Abuse

Change in the Condition of

Plaque in the Coronary
Artery

Activation of Platelets
Rest
Pain
Platelet Aggregation,
Adhesion, & Buildup of
Claudi- Platelet Mass
cation
ATHERO- THROMBOSIS
SCLEROSI
S
N/V
Release of
Thromboplastin

Fainting
Platelet release Thromboxane
A2, Serotonin, Platelet Factors
3&4
Sweating
Coagulation and
Vasospasm
Cool
extremities
Enlargement of
Thrombus
1