Patofisiologi BPH

Aging

Regulatory TGF- Expression of

<< antiapototic gene
gene >>

Inhibitor
proliferation BCL 2
<<

Proliferatio
n >>

Hyperplasia

Produce & secrete GF

(HB-EEGF, bFGR/FGR-
2)
GF ECM Testostero
(extracellular ne
matrix)>> Enzyme
5

Promotes adhesion, DHT

migration,
proliferation epithel
and stromal cells
Reseptor
Expression CRY 61 >> (AR)
(an early immediate
respon gene)
Hormone complex
receptor

Affect normal
cell morphology
Tranformation
Imbalance nuclear
Masuk receptor
nuklesu
proliferation and cell dan melekat dgn
death kromatin

Expression
Capable VEGF
of secreting Trankripsi
Inflammation
Hyperpla
BPH Sintesis
Pertumbuhan
(potent
potent epithelial
epithelial
Activated T andprotein
mRNA>>
sia prostat >>
(Roerborn, 2004; Kramer, 2007; Rosette, 2006).

Roehrborn CG, Schwinn DA. 2004. Alpha1-adrenergic receptors and

their inhibitors in lower urinary tract symptoms and benign
prostatic hyperplasia. J Urol;171(3):102935.
Kramer G, Mitteregger D, et al. 2007. Is benign prostatic hyperplasia
(BPH) an immune inflammatory disease? Eur Urol ;51(5): 1202
16.
Rosette, J. de la. , G. Alivizatos, S. Madersbacher, C. Rioja Sanz, et al.
2006. Guideline Prostatic Hyperplasia: European Association of
Urology.