Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
London: WB Saunders,
1975:116-143
17 Marquez-Montes J, Rufilanchas JJ, Esteve-Alderete JJ, Mendez
J, Ugarte J, Rodriguez E, et al. Tratamiento quirurgico en 24
pacientes con sindrome de Wolff-Parkinson-White y taquicardias: diagnostico topografico de los haces de Kent y evaluacion de
resultados. Rev Esp Cardiol1981; 34:271-281
18 Josephson ME, Horowitz LN, Farshidi A, Spear JF, Kastor JA,
Moore EN. Recurrent sustained ventricular tachycardia: 2.
Endocardial mapping. Circulation 1978; 57:440-447
19 Janse MJ, Van Capelle FJL, Anderson RH, Touboul P, Billette J.
Electrophysiology and structure of the atrioventricular node of
the isolated rabbit heart. 1n: Wellens HJJ, Lie KI, et al, eds. The
conduction system of the heart. Leiden: Stenfert & Kroese, 1976:
296--315
--------~~---------------~--------------------------~L__
!
!
I
~~~~~~
f.
3LSB
~~~.,.
~.;.,.~,
Expiration
Inspiration
FIGURE 1. Respiratory change in the intensity of systolic murmur. During expiration the intensity of the
systolic murmur was increased whereas its intensity was markedly decreased during inspiration.
Reversed Rlvero-Carvallo's Sign (Ishikawa et 81)
___.~~~~L../\__i.-/\._
ICP
M 1 ---~~111!1""----~~!),~
M2
___ . ., "",;u;~.
--.,..rl!;_;~-:~...,---+-"'')~iti;
-----<::t,~,.,~
___
.oj,.._,__..,.....-
___..,. ;.~
H
lneplratlon
Expiration
FIGURE 2. lntracardiac phonocardiography recorded in the outflow tract of the right ventricle. The systolic
munnur became louder on expiration than on inspiration.
PA
RV
RA
3. Right heart catheterization. The pressure was continuously recorded while the catheter tip was
being slowly drawn from the pulmonary artery to the right atrium. There was a slight but clearly apparent
pressure gradient between the right ventricular outflow portion and inflow portion.
FIGURE
V2
VJ
1/2
1/2
V4
Vs
1/2
REFERENCES
Lockhart A, Charpentier S, Bourdarias JP, Ismail MB, Ourbak P,
Scebat L. Right ventricular involvement in obstructive cardiomyopathies; haemodynamic studies in 13 cases. Br Heart J
1966; 28:122
Azathioprine-Associated
Pulmonary Dysfunction*
Michael]. Krowka, M.D.t; Richard I. Breuer, M.D.:!:; and
Vs
CASE REPORT
A 35-year-old man was admitted for evaluation of intermittent
fever (39.4C). Crohn's disease had been diagnosed when he was
aged 17. Four bowel operations performed because of obstruction or
fistulas resulted in an ileostomy in 1970. Subsequent medical
therapy included a two-month trial of azulfidine because of radiologic demonstration of ileal recurrence two years prior to admission.
Kidney stones were passed in 1971, 1972, and 1979. Stone analysis
indicated 90 percent urate in each instance. Allopurinol therapy was
begun two years prior to admission and continued at doses ranging
from 100 to 200 m!day. Eight months prior to admission, ileal
obstruction resolved with tube decompression and initiation of
prednisone therapy, 60 mglday. The prednisone was decreased to 20
mglday, but four months later bleeding from the ileum recurred.
Azathioprine, 50 m!day, along with prednisone, 40 m!day, successfully controlled the bleeding. By one month prior to admission,
prednisone had been reduced to 40 mg every other day and
azathioprine had been increased to 125 m!day. At no time did the
patient complain of respiratory difficulties.
Physical examination indicated blood pressure of 120/80 mm Hg
without orthostatic changes. Temperature was 39.1C orally, respirations 18 per minute, with a regular pulse rate of90 per minute. The
chest was clear to auscultation and percussion. Cardiac examination
was within normal limits. Abdominal examination was significant for
mild, diffuse tenderness without rebound or hepatosplenomegaly.
There was no adenopathy, and the neurologic examination was
normal.
Fever workup included cultures of induced sputum, urine, blood,
spinal Ouid, and bone marrow. All were negative. Chest roentgenograms were normal. The WBC was elevated to 15,500/cu mm, with
65 percent polymorphonuclear leukocytes and no eosinophils.
Atypical lymphocytes were not seen on the peripheral smear.
Antinuclear antibody and rheumatoid factor titers were less than
1:20. Lymphocyte stimulation, immune complex, and complement
studies were not done. Hepatorenal function was normal, and the
urinalysis was unremarkable. Forty-eight hours after admission,
azathioprine and allopurinol therapy was stopped, and prednisone
administration continued at 40 mglday. A 07Ga scan obtained to locate
a possible abdominal abscess was unremarkable. However, both
lungs demonstrated spectacular uptake at 6, 24, and 48 hours after
Azalhloprlne-8SSOCialed Pulmonary Dysfunction (Ktowlra et al)