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Charles B. Huggins
Nobel Prize for Hormonal Treatment of Prostatic
Cancer

Mai Hong Yn (Lala)

On my honor, I have neither received nor given any unauthorized aid
on this assignment.

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A world is gradually developing and becoming more modern till this 21st Century. The
researches of a lot of biologists are a part that contributes the great world of the present. Charles
B. Huggins, one of the legends of physiology, is also known as Charles Brenton Huggins. He
was born on Septemeber 22nd , 1901 in Halifax,Nova Scotia and died on January 12th , 1997 in
Chicago, Ill., U.S. Dr. Huggins was the great scientist who won the Nobel Prize for Hormonal
Treatment of Prostatic Cancer. Besides, He had married a woman named Bessie Maria Spencer
and his elder was Charles Edward Huggins, a pharmacist. Discovery is our business is
Charless motto in his job.
According to Nobelprize.org, cells grow up quickly without limit in every cancer. One of
Charless successful researches was about prostate cancer. Prostate cancer is a cancer which
attacks and causes negative effects a gland a part of male sex organ. Not only that, prostate
cancer is also the most common cancer in men. Quoting National Cancer Institute, when the man
is imbued prostate cancer, the prostate gland makes fluid that forms part of semen. The prostate
lies just below the bladder in front of the rectum. It surrounds the urethra (the tube that carries
urine and semen through the penis and out of the body). However, a process of prostate cancer
grows very slowly; most of the men who get this cancer are older than 65 years old and do not
die because of it.
As the information, Dr. Huggins was professional on the male urological and genital
tract. In the early 1940s, he found the way to slow down the growth of prostate cancer by
preventing the action of the patients male hormones with the amount of the female hormone
estrogen. This research of Charles proved that some cancer cells, such as ordinary body cells, are
dependent on hormonal signals to stay alive and grow. Therefore, if we remove cancer cells of
the correct signals, the growth of tumours could be slowed down. Although its effectiveness
doesnt last for a long time, but at least temporarily. According to John Easton, in order to
research and demonstrated the relationship the endocrine system and the normal action of the
prostate gland; Charles had to work all day and night with his excellent students: Clarence V.
Hodges and William Wallace Scott. Through many experiments on treatment of prostate cancer;

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Charles and his students showed that if we prevent the male hormones which are involved in
prostate function by removing the testicles or administration of estrogens, which would
neutralize the male hormones, it would cause the regression or throwback of prostate tumors.
Both of regression and the ensulting relief of pain often occur within many days or many hours
after treatment. However, four of twenty one hormone-therapy patients of Charles could live
more than 12 years with health in dynamic life.
Quoting Paul Talalay - Director of Pharmacology and Experimental Therapeutics at
Johns Hopkins University, Humanity owes Charles Huggins deep gratitude. Dr. Huggins
researches had totally changed the way that scientists used to think about the behavior of all cell
cancers. It also raised the development of science up the new treating advanced cancer. Charles
discovered the way to treat the prostate cancer and make the male patient can live a longer life.
"It heralded an era of rational chemotherapy of cancer," added Dr. Talalay. Dr. Huggins
pioneering contributions to the prostate cancer had made a lot of changes on cancer
chemotherapy. After the research about prostate cancer, Charles had moved to other objects,
such as breast cancer.
In my opinion, I can apply his discover by treating the men who have prostate cancer.

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Some pictures of Charles B. Huggins

Charles was old.

Charles was young.

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Works Cited
"Charles B. Huggins - Facts". Nobelprize.org. Nobel Media AB 2014. Web. 13 Oct 2016.
<http://www.nobelprize.org/nobel_prizes/medicine/laureates/1966/huggins-facts.html>
"Charles B. Huggins". Encyclopdia Britannica. Encyclopdia Britannica Online.
Encyclopdia Britannica Inc., 2016. Web. 13 thg 10. 2016
<https://www.britannica.com/biography/Charles-B-Huggins>.
Easton, John. The University of Chicago Medicine. N.p., n.d. Web. 13 Oct. 2016.
<http://www.uchospitals.edu/news/1997/19970113-huggins.html>.
National Cancer Institute. N.p., n.d. Web. 13 Oct. 2016.
<https://www.cancer.gov/types/prostate>.