DOSAGES AND INDICATIONS OF THE CEPHALOSPORINS APPROVED FOR

VETERINARY USE
1. CATTLE, SHEEP AND GOATS

Approved Dose, mg Route Interval Major indications

cephalosporin per kg (Hour)
Ceftiofur 1.1-2.2 IM ,SC 24 Acute metritis , Retained
sodium, fetal membranes,
Ceftiofur Bacterial pneumonia, bovine
respiratory disease complex
HCL, 50mg/ml
(shipping fever),
Pododermatitis, acute
Ceftiofur bovine interdigital
6.6 SC 24 necrobacillosis , Severe
crystalline free
acid suspension coliform mastitis

Cefazolin 15-20 IV,IM,SC 12 bone, joint, respiratory, skin,

soft tissue infections
Mastitis
Cephapirin 10 IM 8
Mastitis
200mg Intramammary 12
totaldose
Cefoperazone 250 mg Intramammary Single
Total Mastitis
dose
dose
250 mg
total dose Intramammary Single Mastitis
Cefuroxime
dose
Cephacetrile 250 Intramammary
mgTD SD
55 skin, soft tissue infections
Cephalothin SC
6
25-50 24 Serious complicated
Ceftriaxone IM,IV respiratory, CNS,
Genitourinary tract
infections
25 12 n preruminant calves only ,
Cefadroxil PO
7 12 for wound infections
Cephradine PO

10 24 Upper respiratory tract and

Cefetamet PO urinary tract infections
(preruminant
calves)
IM Anti pseudomonal
Ceftazidime 20-40 12-24
cephalosporin
2. HORSES:

Approved Dose mg per Route Interval Major

cephalosporin kg (Hour) indications
Ceftiofur 2.2-5.5 IM,IV 24 Bone, joint,
sodium respiratory,
skin, soft
tissue, and
urinary tract
infections.

Cefotaxime Neonatal
20-30 IM,IV 8 sepsis and
secondary
bacterial
meningitis
Cephradine 10-20 IV 8 bone, joint,
(foals) respiratory, skin,
soft tissue, and
urinary tract
infections
Cefadroxil 10-20 PO 8-12 skin and soft
(foals) tissue infections
and urinary tract
infections
Cefazolin 10-20 IV 6-8 prophylaxis of
Perioperative
infections
Cephalexin skin and soft
25-33 PO 6 tissue infections
bone, joint,
Ceftriaxone respiratory, skin,
25-50 IM,IV 12-24
soft tissue,CNS
and urinary tract
infections
Cefamandole 10-30 IV,IM 4-8 General
indications of
Cefoperazone respective
30-50 IM.IV 6-8 generation
cephalosporins
Gram
Cefoxitin negative or
20 IV,IM 8 polymicrobial
anaerobic
 infections

Cephalothin 10-30 IM,IV 6

Susceptible
bacterial
infections
Cephapirin 20-30 IM,IV 8-12
50 PO 8-12

Serious
Cefpodoxime 5-10 PO 6-12 respiratory
proxetil infections, skin,
Cefepime soft tissue
2.2 IM 8 Nosocomial and
urinary tract
Cefpirome infections
11 IM 8

Ceftazidime Antipseudomonal
25-50 IV,IM 8-12 cephalosporin

Moxalactam 50 IV,IM 8

3. DOGS

Approved Dose mg Route Interval Major indications

cephalosporin per kg (Hour)
Cefazolin 10-30 IV,IM,SC 6-8 prophylaxis of
Perioperative
infections-
including bone
Cefaclor surgery
15-30 IV,IM, 6-8 susceptible
bacterial skin, and
soft tissue
infections
Cefixime 5-10 PO 12-24 bone, bladder,
respiratory ,skin
and soft tissue e
infections.
Cefoxitin 10-20 PO 8-12 G -ve anaerobes
15-30 IV,IM,SC 6-8
30 IM,IV 8 G-veor
Cefotetan polymicrobial
anaerobic
infections

25-50 IM,IV,SC 8-12 Major gram

Ceftazidime negative
including
Pseudomonal
infections
5-10 PO 12 Skin and soft tissue
Cefpodoxime infections
proxetil
10-30 IM,IV 4-8 Susceptible
Cephalothin bacterial infections

15-30 PO 12
Cephradine skin and soft tissue
infections
skin ,soft tissue
10-25 PO 8-12
infections
Cephalexin skin ,soft tissue
10-20 PO 12 infections
Cefadroxil skin inf.
(pyoderma),urinary
8 SC 14 days tract infections
Cefovecin

10-20 IM,IV 6-8 pyoderma

Cephaloglycin

10-20 8-12 6-8 Staphylococcal

Cephapirin 10-30 IM 8 infections
Cefamandole
15-50 IM,IV 24 bone, joint,
Ceftriaxone respiratory, skin,
soft tissue,CNS
and urinary tract
infections

Cefoperazone 20 IM 6-8 Antipseudomonal

20-40 IV,IM 8-12 Respiratory, skin,
Cefotaxime soft tissue, and
urinary tract
2.2 IM 24 infections
Ceftiofur
Respiratory, skin,
sodium
soft tissue, and
25-40 IV,IM 8-12 urinary tract
Ceftizoxime infections
10-15 IV 8-12
Cefuroxime Respiratory, skin,
soft tissue, and
urinary tract
4-8 PO 12-24 infections
Cefetamet
4. CATS

Approved Dose mg Route Interval Major indications

cephalosporin per kg (Hour)
Cephalexin 10-30 IV,IM, SC 6-8 Respiratory,
skin, soft tissue,
and urinary tract
infections
Cefotaxime Bone,respiratory,
20-40 IV,IM 8-12 skin, soft tissue,
and urinary tract
infections
Cefadroxil 10-20 PO 12 Skin and soft tissue
and urinary tract
infections
Respiratory, skin,
Ceftriaxone 15-50 IM, IV 24 soft tissue,CNS and
urinary tract
infections

5. PIGS

Approved Dose mg Route Interval Major indications

cephalosporin per kg (Hour)
Ceftiofur 3-5 IM 24
(Free acid) Respiratory tract
infections
Ceftiofur 5 IM 5days
crystalline oil
suspension
(100mg/ml)
1. POULTRY:

Approved Dose mg Route Interval Major indications

cephalosporin per kg (Hour)
Cephalexin 25-50 PO 8-12 susceptible bacterial
infections in cranes,
ducks, emu, pigeons, and
quails
Ceftiofur 1.3-2.6 IM 24 E. coli infections
(Free acid) susceptible bacterial
Cephalothin 100 IM 8-12 infections in cranes, ducks,
emu, pigeons, and quails