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3 BS Pharmacy
ANTIBIOTIC GROUP
1. Aminoglycosi
des
2. Carbapenems
3. Cephalospori
ns
(1st gen)
EXAMPLE/S
Amikacin,
Gentamicin,
Neomycin,
Tobramycin, etc.
MECHANISM OF ACTION
Bind to the bacterial 30S or
50S
ribosomal
subunit,
inhibiting the translocation of
the peptidyl-tRNA from the Asite to the P-site and also
causing misreading of mRNA,
leaving the bacterium unable
to synthesize proteins vital to
its growth
Inhibition
of
cell
wall
synthesis
Ertapenem,
Doripenem,
Meropenem, etc.
Cefadroxil, Cefazolin, Same mode of action as
Cefalotin, Cefalexin
other beta-lactam antibiotics:
disrupt the synthesis of the
peptidoglycan
layer
of
bacterial cell walls
4. Cephalospori
ns (2nd gen)
Cefaclor,
Cefamandole,
Cefoxitin, Cefuroxime
11.
Tetracyc
lines
Demeclocycline,
Doxycycline,
Oxytetracycline,
Tetracycline
Inhibits
the
binding
of
aminoacyl-tRNA
to
the
mRNA-ribosome
complex.
They do so mainly by binding
to the 30S ribosomal subunit
in the mRNA translation
complex. But Tetracycline
cannot be taken together
with
all
dairy
products,
aluminium, iron and zinc
minerals.