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myeloid or lymphoid
"blasts"
2.
IV solution for SQ
administration, unlike TKI
which are all PO
formulations.
3.
Without, on an empty
stomach.
4.
TRUE
5.
6.
renally
7.
hepatically
8.
9.
10.
BP-CML
11.
More aggressive:
- standard 7+3
- modified 5+2
- FLAG-ida
- FLAG
- MEC
- G-CLAC
-HDAC
Less aggressive
-Low dose cytarabine
-Decitabine
-5-Azacytidine
12.
Chronic phase
13.
-MTX
-Cytarabine
-Hydrocortisone
*must all be preservative
free
15.
Myelosuppression
Hyperglycemia
16.
Age > 70
Radiation
Genetic disorders,
ex:Down syndrome
14.
17.
Environmental exposure
Chemicals (benzene)
Prior chemotherapy exposure
(alkylating agents,
antimetabolites,
topoisomerase inhibitors)
18.
race (caucasian)
advanced age
eastern european or russian
jewish decent
family history
19.
FCR: Fludarabine,
cyclophosphamide, and
rituximab
CVP: Cyclophosphamide,
mitoxantrone, and prednisone
20.
21.
-Hydroxyurea
-5-Azacytidine
-Decitabine
-SQ cytarabine
22.
-Rash
-Neurotoxicity (cerebellar)
-Conjunctivitis
23.
-AKI
-Hepatotoxicity
-Pneumonitis
-Neurotoxicity (cerebellar)
24.
0: lymphocytosis only
1: lymphocytosis with
lympadenopathy
2: lymphocytosis with
hepatomegaly or
splenomegaly
3: lymphocytosis with anemia
4: lymphocytosis with
thrombocytopenia
25.
Levofloxacin or Ciprofloxacin
26.
Valgancyclovir
27.
Posaconazole or Voriconazole
28.
Fluconazole
29.
Acyclovir
30.
Bactrim, dapsone,
atovaquone
31.
Leucovorin 10-25 mg IV
Q6h
Start 24-36 hours after
start of MTX infusion
32.
Glucarpidase, 50
units/kg IV bolus over
5 minutes
33.
34.
-Vincristine
-Anthracycline
-Corticosteroid
(Dex>Pred)
35.
-6MP
-MTX
-Vincristine
-Corticosteroids
+/-TKI
36.
-Blinatumomab
-Vincristine Sulfate
Liposome Injection
-Augmented
HyperCVAD +/Rituximab+/-TKI
-Corticosteroids + TKI
37.
Inhibits dihydrofolate
reductase
38.
Reversible protein
synthesis inhibitor
39.
QT prolongation
40.
B symptoms (fever,
night sweats, wt.loss,
fatigue)
CBC abnormalities
hepatomegaly,
splenomegaly,
lympadenopathy
infection
41.
Eliminate residual
leukemia cells
42.
Achieve complete
remission
43.
44.
-NSAIDS
-BACTRIM
-PPI
45.
46.
47.
48.
Ponatinib.