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INTRODUCTION
Table 1
Highlighted comparisons of SOMAscan with mass spectometry
SOMAscan
Sensitivity
(pg/mL, median)
>1,000
<5
Coefficient of variation
(% median, plasma)
5-20
65
Sample volume
requirements (L)
30-100
1310 (relative)
50-200 (absolute)
< 500 (relative)
Dynamic range
(orders of magnitude)
4 (without dilutions)
Days to weeks
Throughput time
(large projects)
Weeks to months
No
Identifying protein-protein
complexes
No
No
Identifying proteomforms
(e.g, PTMs, sequence variants)
Yes
No
No
Days to weeks
6
VS.
Mass
Spectometry
Turnaround time
(large projects)
Weeks to months
Summary
Neither MS nor the SOMAscan assay provides a complete
solution for all proteomics needs, though SOMAscan has a
significant edge in hypothesis-free protein biomarker discovery
in terms of throughput, multiplexing, sensitivity and dynamic
range. In addition, individual SOMAmer reagents can enhance
MS-related methods that currently rely on antibodies. As both
technologies continue to evolve, the individual researcher
must determine which technology is best suited for his/her
particular needs.
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