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Electrochemical Biosensors based on

Acetylcholinesterase and
Butyrylcholinesterase. A Review
Article in International journal of electrochemical science September 2016
DOI: 10.20964/2016.09.16

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Miroslav Pohanka
University of Defence
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Retrieved on: 04 September 2016

Int. J. Electrochem. Sci., 11 (2016) 7440 7452

International Journal of

ELECTROCHEMICAL
SCIENCE
www.electrochemsci.org

Short Review

Electrochemical Biosensors based on Acetylcholinesterase and

Butyrylcholinesterase. A Review
Miroslav Pohanka
Faculty of Military Health Sciences, University of Defense, Trebesska 1575, Hradec Kralove, Czech
Republic; Department of Geology and Pedology, Mendel University in Brno, Czech Republic
E-mail: miroslav.pohanka@gmail.com
doi: 10.20964/2016.09.16
Received: 8 May 2016 / Accepted: 23 June 2016 / Published: 7 August 2016

Two cholinesterases are known: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The
both enzymes are presented in the body under physiological conditions and the both enzymes have
broad use in pharmacology, toxicology and analyses. In the current paper, construction of
electrochemical biosensors, a specific phenomenon in analytical chemistry, is reviewed. Development
of voltammetric and potentiometric methods using standard electrodes, nanostructured materials,
micro and nanoparticles is described here commonly with depicting of reaction principles and selection
of substrates for the cholinesterases. Survey of actual literature is also provided within the article and
disparate analytes used for the biosensors testing are introduced.

Keywords: Acetylcholinesterase; biosensor; butyrylcholinesterase; conductometry; nerve agent;

pesticide; potentiometry; voltammetry
FULL TEXT
2016 The Authors. Published by ESG (www.electrochemsci.org). This article is an open access
article distributed under the terms and conditions of the Creative Commons Attribution license
(http://creativecommons.org/licenses/by/4.0/).