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Total Marks: 75
QUESTION 1. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following is an anabolic hormone?
A) glucagon
B) thyroxine
C) growth hormone
D) cortisol
E) insulin
QUESTION 2. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Foods to be eaten in moderation in diabetes include:
1. green vegetables
2. tomato
3. meat extracts
4. milk
QUESTION 3. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding the mechanism of action of metformin (biguanide), which of the following statements is
incorrect?
A) have no hypoglycaemic effect in normal people
B) increases peripheral glucose uptake
C) stimulates insulin secretion
D) reduces hepatic gluconeogenesis
E) do not cause hypoglycaemia
QUESTION 4. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A 55 year old male patient presents with symptoms of febrile episodes accompanied by regional
adenopathy. On physical examination, an eschar is found with generalized red-brown rash
throughout his trunk. What is the most probable diagnosis?
A) typhoid fever
B) African trypanosomiasisi
C) relapsing fever
D) rat-bite fever
E) dengue fever
QUESTION 5. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Pathological changes typical of NIDDM include all of the following except
A) amyloid deposition in islets
B) reduction in the number of insulin secreting cells
C) islet cell atrophy
D) decreased anabolism
E) atrophy of glucagon secreting cells
QUESTION 6. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Gene implicated for susceptibility towards dengue shock syndrome:
A) major histocompatibility complex class I
B) interleukin-23 receptor
C) interleukin-28B
D) mannose-binding lectin
E) FUT2, fucosyltransferase
QUESTION 7. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Life-threatening features of acute severe asthma
1. bradycardia
2. tachycardia >120 per min
3. central cyanosis
4. unable to speak in sentences
QUESTION 8. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following is a homopolysaccharide?
1. dextrins
2. heparin
3. amylopectin
4. neuraminic acid
QUESTION 9. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding oxygen dissociation curve and oxygen binding to Hb, spot the incorrect statement:
A) fetal hemoglobin has a higher oxygen affinity than adult Hb
B) regulated by H+
A) eosinophils
B) basophils
C) lymphocytes
D) neutrophils
E) monocytes
QUESTION 26. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding immunogenicity of therapeutic preparations of insulin, sopt the correct statements?
A) protamine in insulin preaparation is highly immunogenic
B) acidity decreases immunogenicity
C) porcine insulin is most antigenic
D) newer insulin preparations contain trace amounts of pro-insulin
E) bovine insulin is most antigenic
QUESTION 27. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding the genetic susceptibility to diabetes (IDDM), correct is/are:
A) amino acid substitution at HLA-BQ beta chain
B) high susceptibility for Asp-positive homozygosity
C) amino acid substitution at HLA-DQ alpha chain
D) high susceptibility for Asp-negative homozygosity
E) high susceptibility for Asp-positive heterozygosity
QUESTION 28. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following contains Zinc as a cofactor?
A) EcoRV endonuclease
B) Vitamin B12
C) cytochrome c oxidoreductase
D) alcohol dehydrogenase
E) nitrogenase
QUESTION 29. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Community acquired pneumonia is most likely due to
A) Streptococcus pneumoniae
B) Klebsiella
C) E.coli
D) Staphylococcus aureus
E) Pseudomonas aeruginosa
QUESTION 30. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Cell derived mediators of acute inflammation include:
1. nitric oxide
2. histamine
3. prostacyclin
4. C3a
QUESTION 31. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Energy sources during the initial stages of strenous exercise is from:
A) oxidation of ketone bodies
B) oxidation of glycogen
C) anaerobic glycolysis
D) aerobic glycolysis
E) oxidation of fatty acids
QUESTION 32. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the statements True or False:
A) K+ is essential for development of action potentials in nerve cells
B) Cl is an important anion of intracellular fluids
C) Na is the predominant ionic constituent of blood plasma
D) Na+ is essential for development of resting potentials across membranes
E) Na+ is essential for development of action potentials in nerve cells
QUESTION 33. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Maternal deficiency of which vitamin is associated with neural tube defects of the newborn?
A) folic acid
B) riboflavin
C) thiamine
D) biotin
E) vitamin D
QUESTION 34. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A 35 year old male presents with intermittent fever, headache, pruritus and petechhiae on his left
leg. On laboratory examination, there is leukopenia. What is the most probable diagnosis?
A) malaria
B) dengue
C) typhoid fever
D) rat-bite fever
E) relapsing fever
QUESTION 35. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following statements regarding 'insulin preparations' are correct?
1. Duration of action of Hypurin isophane is 12 hrs
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Short-acting insulin:
1. Hypurin neutral
2. Hypurin protamine
3. Humulin S
4. Humulin Zn
QUESTION 42. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Dengue hemorrhagic fever is cause by a virus which belongs to genus
A) Alphavirus
B) Plebovirus
C) Reovirus
D) Bunyavirus
E) Flavivirus
QUESTION 43. Choose the SINGLE MOST CORRECT option (A-E) listed below.
S-Adenosylmethionine (SAM) is synthesized from
A) homocysteine and ATP
B) methionine and ATP
C) cysteine and ATP
D) 5-methyltetrahydrofolate and ATP
E) methionine and folic acid
QUESTION 44. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following is found in lowest concentration in normal seminal fluid?
A) glycerylphosphorylcholine
B) magnesium
C) zinc
D) carnitine
E) acid-phosphatase
QUESTION 45. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following is involved in energy transfer reactions mediated by ATP?
A) Co
B) Sulphur
C) Mg
D) Zn
E) Cu
QUESTION 46. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the statements True or False:
QUESTION 52. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the statements True or False:
A) glipizide has a biological half-life of about 10-12 hrs
B) glibenclamide can induce severe hypoglycemia
C) biguanides have a very low incidence of side effects compared to sulphonylureas
D) tolbutamide can induce disulfiram-like reactions in some patients after taking with alcohol
E) chlorpropamide can induce SIADH
QUESTION 53. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Correct about normal CSF values:
A) CSF volume 150 mL
B) CSF pressure 50-120 mm H2O
C) Lymphocytes 30-50%
D) Ig G 0.5-.7.9 mg/dL
E) albumin 16.6-24.2 mg/dL
QUESTION 54. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Regarding non-insulin dependent diabetes mellitus (NIDDM) spot the correct statements:
A) hexokinase gene mutation is associated with MODY
B) Coxsackie B4 virus and reo virus type I are implicated in inducing NIDDM
C) HLA-linked polygenic inheritance
D) profound insulin resistance
E) have autoimmune etiopathology
QUESTION 55. Choose the SINGLE MOST CORRECT option (A-E) listed below.
The basic structure of histone in DNA is rich in
A) histidine and isoleucine
B) glutamine and methionine
C) glycine and alanine
D) arginine and lysine
E) asparagine and proline
QUESTION 56. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the following statements 'true' or 'false':
A) hyaluronic acid is an acidic mucopolysaccharide
B) galactose on oxidation gives mucic acid crystals
C) Indican is an example of aglycone
D) glucose on reduction gives mannitol
E) fructose on reduction gives sorbitol
QUESTION 57. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
The energy requirements of muscle at rest is from
1. fatty acids
2. glycogen
3. ketone bodies
4. pyruvate
QUESTION 58. Choose the SINGLE MOST CORRECT option (A-E) listed below.
The most important laboratory test in the evaluation of male infertility:
A) Semen analysis
B) GnRH simulation test
C) Antisperm antibodies
D) Testosterone concentration
E) FSH measurement
QUESTION 59. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A sulphur containing amino acid that requires folic acid as a cofactor
A) homocystine
B) cysteine
C) histidine
D) homocysteine
E) serine
QUESTION 60. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following is a second generation sulphonurea?
1. chlorpropamide
2. glibenclamide
3. tolbutamide
4. glipizide
QUESTION 61. Choose the SINGLE MOST CORRECT option (A-E) listed below.
The locus of HLA Class II genes associated with diabetes
A) long arm of chromosome 5
B) short arm of chromosome 6
C) short arm of chromosome 8
D) long arm of chromosome 6
E) short arm of chromosome 5
QUESTION 62. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Correct statements about the clinical features of insulin-dependent diabetes mellitus (IDDM):
1. positive family history of diabetes
2. autoantibodies against insulin not detected
3. obesity is a risk factor for IDDM
4. presence of ketonuria
QUESTION 63. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Characteristic pathological features of bronchial asthma include all of the following except:
A) shedding of the epithelium
B) mucus plugging
C) hypertrophy of the bronchial arteries
D) smooth muscle hypertrophy
E) plasma exudation
QUESTION 64. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Which of the following statements regarding Semen analysis is/are incorrect as per WHO one
sided reference values?
A) morphologically normal forms 8%
B) total sperm number 39 million per ejaculate
C) 58% live
D) progressive motility 32%
E) sperm concentration 15 million/mL
QUESTION 65. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Bond dissociation energy of single bond O-H is about
A) 435 kJ/mol
B) 414 kJ/mol
C) 470 kJ/mol
D) 348 kJ/mol
E) 419 kJ/mol
QUESTION 66. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Functions of insulin: Mark the statements True or False
A) increased lipoprotein lipase activity
B) increases fatty acid oxidation
C) decreases cellular potassium uptake
D) increased lipolysis
E) decreases glycogenolysis
QUESTION 67. Choose the SINGLE MOST CORRECT option (A-E) listed below.
D) acid-phosphatase
E) glycerylphosphorylcholine
QUESTION 73. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Diagnosis of diabetes is certain when there is
1. HbA1 > 7.0%
2. glycosuria
3. ketonuria
4. ketonuria with glycosuria
QUESTION 74. Choose the SINGLE MOST CORRECT option (A-E) listed below.
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding diagnosis of diabetes correct is when:
1. RBS >14 mmol/L
2. RBS >6 mmol/L
3. Urinary glucose conc. >1.11 mmol/L
4. Urinary glucose conc. >0.44 mmol/L
QUESTION 75. Choose the SINGLE MOST CORRECT option (A-E) listed below.
An example of a modified, delayed onset long acting insulin preparation:
A) Velosulin
B) Humulin S
C) Actrapid
D) Insulatard
E) Hypurin neutral
ANSWERS