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1. The Neuron
• Most neurons contain many dendrites (neuron’s receivers) – receive impulses then
carry toward the cell body.
• Most neurons have only one axon (neuron’s transmitter) – conducts impulses away
from the cell body.
• Axon splits near its end into branches called axon terminals (terminal fibrils).
• The tips of the axon terminals are called the synaptic knobs containing vesicle
(sacs) filled with chemicals, known as neurotransmitter – used for communication
between neuron and another cell.
• Nerve impulse is an electrical charge – is the signal that passes from one neuron to
the next and finally to an end organ.
• Changes in the membrane potential are signals used to receive, transmit and
integrate information within & between cells.
• These signals are of two (2) types – graded potentials & action potentials. Both
are electrical currents created by the movement of ions
Graded Potentials
• These are localized changes in the membrane potential – can be either
depolarizations or hyperpolarizations.
• These are triggered by local changes in the neuron’s local environment.
Action Potentials
• An action potential is a rapid and substantial depolarization of the neuron’s
membrane.
• Typically, membrane potential changes from the RMP -70 mV to a value of
+30 mV, and then rapidly returns to its resting value.
• All action potentials begin as graded potentials. Action potentials are
generated when enough stimulation occurs to cause a depolarization (at least 15 –
20 mV).
• That means if the membrane depolarizes from the RMP of -70 mV to a value
of -50 mV to -55 mV, the cell will experience an action potential.
• The minimum depolarization required to produce an action potential is called
the “threshold”.
• Any depolarization less than the threshold value of 15 – 20 mV will not result
in an action potential. This is the “All-or-None Principle”.
3. The Synapse
• The neuromuscular junction is where motor neuron communicates with the muscle
fiber.
• It involves:-
1. Presynaptic axon terminals (motor endplates),
2. The synaptic cleft, &
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5. Neurotransmitters
SUMMARY
1. Nerve impulses typically pass from the dendrites to the cell body and from the cell body
along the length of the axon to its terminal fibrils.
2. A neuron’s RMP of -70 mV results from the separation of sodium & potassium ions
maintained primarily by the sodium-potassium pump, coupled with low sodium permeability
& high potassium permeability of the neuron membrane
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3. Any change making the membrane potential more positive is a depolarization. Any change
making this potential more negative is a hyperpolarization. These changes occur when
ion gates in the membrane open, permitting ions to move from one side to the other.
4. If the membrane is depolarized by 15 -10 mV, threshold is reached & an action potential
results. Action potentials are not generated if threshold is not met.
6. In myelinated neurons, the impulse travels through the axon by jumping between
nodes of Ranvier (gaps between the cells that form the myelin sheath). This
process, salutatory conduction, is 5 to 50 times faster than in unmylinated
fibers of the same size.
9. A synapse involves:
• the axon terminals of the presynaptic neuron,
• the postsynaptic receptors on the dendrite or cell body of the next neuron, &
• the space (synaptic cleft) between the two neurons.
10. A nerve impulse causes chemicals called neurotransmitters to be released from the
presynaptic axon terminals into the synaptic cleft.
11. Neurotransmitters diffuse across the cleft and are bound to the postsynaptic
receptors.
12. Once neurotransmitters are bound, the impulse has been successfully transmitted
and the neurotransmitter is then either destroyed by enzymes or actively
returned to the presynaptic neuron for future use.
13. Neurotransmitter binding at the postsynaptic receptors opens the ion gates in that
membrane and can cause depolarization (excitation) or hyperpolarization
(inhibition), depending on the specific neurotransmitter and the
receptors to which it binds.
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CNS
• CNS is composed of the brain and the spinal cord.
• CNS houses more than 100 billion neurons.
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1. The Brain
Cerebrum
• Composed of the right & left cerebral hemispheres.
• These are connected to each other by fiber bundles (tracts) referred to as the
corpus callosum, allowing the 2 hemispheres to communicate with each other.
• The cerebral cortex (gray matter) forms the outer portion has been referred to as
the site of the mind & intellect.
• Cerebral cortex is the conscious brain. It allows us to think, to be aware of sensory
stimuli, & to voluntary control of movements.
• Cerebrum consists of 5 lobes: - 4 outer lobes & the central insula (not discuss)
1. Frontal lobe – general intellect & motor control,
2. Temporal lobe – auditory input & its interpretation,
3. Parietal lobe – general sensory & its interpretation,
4. Occipital lobe - visual input & its interpretation.
Diencephalon
• Composed of the thalamus & the hypothalamus.
• Thalamus is an important sensory integration center.
• All sensory input (except smell) enters the thalamus & is relayed to
the appropriate area of the cortex.
• Thalamus regulates what sensory input reaches the conscious brain, &
thus is very important for motor control.
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Cerebellum
• Located behind the brain stem.
• Connected to numerous parts of the brain & has a
crucial role in controlling movement.
Brain stem
• Composed of the midbrain, the pons, & the medulla oblongata.
• Is the stalk of the brain, connecting the brain & the spinal cord.
• All sensory & motor nerves pass through the brain stem as they relay information
between the brain & the spinal cord.
• Also contains the major autonomic regulatory centers that exert control over the
respiratory & cardiovascular systems.
• A specialized collection of neurons running the entire length of the brain stem,
known as the reticular formation, are influenced by & have an influence on nearly all
areas of the CNS. These neurons help:-
1. coordinate skeletal muscle function,
2. maintain muscle tone,
3. control cardiovascular & respiratory functions, &
4. determine our state of consciousness (both arousal & sleep).
The brain has a pain control system, called an analgesia system. The
enkephalins &
ß-enorphin are important opiate substances that act on the opiate receptors in the
analgesia system to help reduce pain. Exercise of long duration has been postulated to
increase the natural levels of these opiate substances.
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• Functionally, the PNS has 2 major divisions: sensory division & motor
division.
• The sensory division of PNS carries sensory information from sensory receptors
toward the CNS.
• Sensory (afferent) neurons originate in such areas: blood & lymph vessels, internal
organs, special sense organs (taste, touch, smell, hearing, vision), the skin, and
muscles & tendons.
• Sensory neurons in the PNS end either in the spinal cord or in the brain.
• Special muscle & joint nerve endings are of many types & functions, and each
type is sensitive to a specific stimulus:
o Joint kinesthetic receptors located in the joint capsules are sensitive to joint
angles & rates of change in these angles. Thus, they sense the position & any
movement of the joints.
o Muscles spindles sense how much a muscle is stretched.
o Golgi tendon organs detect the tension applied by a muscle to its tendon,
providing information about the strength of muscle contraction.
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• The motor division of PNS carries motor impulses out from the CNS to
various part of the body (target areas – muscles) through the motor (efferent)
neurons.
• The motor division is divided into 2 components: the autonomic nervous system
(involuntary) & the somatic nervous system (voluntary).
• The ANS controls the body’s involuntary internal functions. Some of these
functions that are important to sport & activity include heart rate, blood pressure,
blood distribution, & respiration.
• ANS has 2 major divisions: the sympathetic NS & the parasympathetic NS.
• The effects of the two systems are often antagonistic, but both systems
are always functioning together.
Functions not directly needed are slowed (e.g., renal function, digestion),
conserving energy so that it can be used for action.
Causes vasoconstriction; decreases urine formation (Kidney).
Decreases activity of glands & muscles; constricts sphincters (Digestive
System).
The Parasympathetic Nervous System
1. Sensory Input
• Sensory input can terminate in sensory areas of the brain stem, the cerebellum, the
thalamus, or the cerebral cortex.
• An area in which the sensory impulses terminate is referred to as an integration
center. This is where the sensory input is interpreted & linked to the motor system.
2. Motor Control
• Skeletal muscles are controlled by impulses conducted by motor (efferent) neurons
that originate from any of 3 levels: the spinal cord, the lower regions of the brain,
& the motor area of the cerebral cortex.
• The degree of movement complexity increases from simple reflex control to
complicated movements requiring thought processes.
• Motor responses for more complex movement patterns typically originate in the
motor cortex of the brain.
3. Reflex Activity
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• A motor reflex is a preprogrammed response; any time the sensory nerves transmit
certain impulses, the body responds instantly & identically
• Reflexes are the simplest form of motor control. They are preprogrammed
responses, therefore not the conscious response.
• All neural activity occurs extremely rapidly, but the reflex is the fastest mode of
response because the body does not need time to make a conscious decision.
Muscle Spindles
• MS are sensory receptors located in the muscle that senses how much the
muscle is stretched.
• A muscle spindle comprises specialized muscle fibers called intrafusal
fibers (inside the spindle) & these fibers are controlled by specialized motor
neurons, called gamma motor neurons.
• Most movements used in sport activities involve control & coordination through the
higher brain centers specially:
The primary motoe cortex,
The basal ganglia, &
The cerebellum.
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The Cerebellum
• Cerebellum is crucial to control of all rapid & complex muscular
activities.
• It helps coordinate the timing of motor activities & the rapid
progression from one movement to the next by monitoring & making corrective
adjustments in the motor activities that are elicited by other parts of the brain.
• It assists the functions of both the primary motor cortex & the basal
ganglia.
• It facilitates movement patterns by smoothing out the movement,
which would otherwise be jerky & uncontrolled.
5. Engrams
• The motor nerve (neuron) and the group of muscle fibers it innervates form a single
motor unit.
• Each muscle fiber is innervated by only one motor neuron, but each motor neuron
can innervates up to several thousand muscle fibers.
• All muscle fibers within a single specific motor unit are homogeneous with respect
to fiber type. Thus we do not find a motor unit has both FT & ST fibers.
• Motor units are generally activated on the basis of a fixed order of recruitment.
This is known as the principle of orderly recruitment.
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• Motor unit are recruited in an orderly manner, therefore specific ones are called on
each time a specific activity is performed.
• The size principle explained that the order of recruitment of motor units is
directly related to their motor neuron size.
• Motor units with smaller neurons (ST fibers) will be recruited first before larger
neurons (FT fibers).
SUMMARY
1. The central nervous system is composed of the brain and the spinal cord.
2. The 4 major divisions of the brain are the cerebrum, the diencephalon, the
cerebellum & the brain stem.
4. The diencephalon includes the thalamus, which reveices all sensory input entering
the brain & the hypothalamus, which is a major control center for homeostasis.
5. The cerebellum, which is connected to numerous parts of the brain, is critical for
coordinating movement.
6. The brain stem is composed of the midbrain, the pons, & the medulla oblongata.
7. The spinal cord carries both sensory & motor fibers between the brain and the
periphery.
8. The PNS contains 43 pairs of nerves: 12 pairs of cranial nerves & 31 pairs of spinal
nerves.
9. The PNS subdivided into sensory division & motor division. The motor division also
includes the autonomic nervous system.
10. The sensory division carries information from sensory receptors to the CNS so
that the CNS is constantly aware of the current status & environment.
11. The motor division carries motor impulses out from the CNS to the muscles.
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12. The autonomic nervous system includes the sympathetic NS, which is the fight-or-
flight system, & the parasympathetic NS, which is the housekeeping system. Though these
systems often oppose each other, they always function together.
13. Sensory-motor integration is the process by which the PNS relays sensory input to
the CNS and the CNS interprets this information then sends out the appropriate motor
signal to elicit the desired motor response.
14. Sensory input can terminate at various levels of the CNS. Not all information
reaches the brain.
15. Reflexes are the simplest form of motor control. They are not the conscious
response. For a given sensory stimulus, the motor response is always identical and
instantaneous.
16. The level of nervous system control varies in response to sensory input according to
the complexity of movement necessary. Simple reflexes are handled by the spinal cord,
whereas complex reactions require involvement of the brain.
17. Muscle spindles trigger reflexive muscle action when the muscle spindle is
stretched.
18. Golgi tendon organs trigger a reflex that inhibits contraction if the tendon fibers
are overstretched.
19. The primary motor cortex, located in the frontal lobe, is the center of conscious
motor control.
20. The basal ganglia, in the cerebral white matter, help initiate some movements
(sustained & repetitive ones) & help control posture & muscle tone.
21. The cerebellum is involved in all rapid & complex movement processes & assists the
primary motor cortex & the basal ganglia in coordinating the response. It is an integration
center that decides how to best execute the desired movement, given the body’s current
position & the muscle’s current status.
22. Though not well understood, engrams are memorized motor patterns, stored in both
the sensory & motor areas of the brain, that are called upon as needed.
23. Each muscle fiber is innervated by only one motor neuron, but each neuron can
innervates up to several thousand muscle fibers.
24. All muscle fibers within a single motor unit are of the same fiber type.
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25. Motor units are recruited in an orderly manner, so that specific ones are called on
each time a specific activity is performed.
26. Motor units with smaller neurons (ST fibers) are called on before those with larger
neurons (FT fibers).
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