Prior Art Search

CorMatrix Cardiovascular, Inc.

Extracellular Matrix Used in Conjunction with Bone and

Bone Cement to Improve Angiogenesis and Cell Ingrowth
Dr. Robert G. Matheny, Chief Scientist
Beecher Lewis, CEO

TABLE OF CONTENTS

Section Title Page

1. PRESENT ART.......................................................................................
2

1.1 Current Application Or Invention............................................................

2
1.2 Novel Points.............................................................................................
2
1.3 Priority Dates...........................................................................................
2

2. PATENT SEARCH.................................................................................
3

2.1 12/611,716– Bone Cement Compositions Having---...............................

3
2.2 12/499,041– Hydrophilic Interpenetrating Polymer---............................
3
2.3 12/372,425– Multi-Solution Bone Cements and---.................................
4
2.4 12/254,516 – Paste-Like Polymethylmethacrylate Bone---.....................
4
2.5 10/716,445 – Injectable Bone Substitute Material...................................
5
2.6 12/473,246 – Injectable Bone/Polymer Composite.................................
5
2.7 11/407,446 – Bone Graft Composition....................................................
5
2.8 11/262,904 – Injectable Soft Tissue Fixation Technique........................
6

3. PUBLIC DOMAIN SEARCH.................................................................

7

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3.1 USC 102(a) Printed Publication Bar........................................................
7
3.1.1 Fibrin Gel-Immobilized Primary Osteoblasts---......................................
7
3.1.2 Bone Graft Substitute Materials...............................................................
7

3.2 USC 102(b) For Sale or Offer for Sale Bar.............................................

7

1. PRESENT ART

1.1 Current Application or Invention

ECM used in conjunction with bone cement and bone to accelerate healing
by improving angiogenesis and cell ingrowth.

• Bone cement causes ends and sides of bone to stick together but do not
provide an environment for the material to become viable tissue. ECM
provides the particular environment for cell growth, migration,
metabolism, and phenotypic maturation.
• Mixing ECM to a cement or orthopedic will allow for bone ingrowth
• The ECM may come from any source, natural or grown in vitro.
• The ECM may be grown on the device by culturing the cells on the
device and then de-cellularizing the combination
• The ECM may be a powder and mixed into the bone cement adhesive
• The ECM may be placed in a sheet form around the cement or cortical
bone matrix
• The ECM may be mixed with cortical bone that has BMPs within it

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 • Mesenchymal stem cells may be mixed with the ECM prior to
placement in the bone or bone cement.

1.2 Novel Points

The invention is unique in the aspect of the use of ECM in combination

with bone and bone cement in an effort to accelerate healing.

1.3 Priority Date

N/A.

2. PATENT SEARCH

2.1 12/611,716– Bone Cement Compositions Having Fiber-Reinforcement

and/or Increased Flowability

Patent Status: Pending

Issue Date: N/A

Filing Date:

Inventor(s): Bryan Monro Armitage, Ira Ison, Mark Fulmer,

Sean Kerr, Michael Lehmicke, Patrick Leamy, William Schiffer

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 Assignee: Synthes USA LLC

Relation to Art: Mentions the combination of Bone Cement

with a separate material in an effort to increase strength.

2.2 12/499,041– Hydrophilic Interpenetrating Polymer Networks Derived

from Hydrophobic Polymers

Patent Status: Pending

Issue Date: N/A

Filing Date: July 7, 2009

Inventor(s): David Myung, Michael J. Jaasma, Lampros Kourtis

Assignee: N/A

Relation to Art: Polymers used in an effort to increase strength

and rigidity.

2.3 12/372,425– Multi-Solution Bone Cements and Methods of Making the

Same

Patent Status: Pending

Issue Date: N/A

Filing Date: Feb 17, 2009

Inventor(s): Danieli C. Rodrigues, Jeremy L. Gilbert, Julie M.

Hasenwinkel

Assignee: Syracuse University

Relation to Art: Very particular on combinations of Bone

Cement with other solutions, primarily with polymers and
monomers

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2.4 12/254,516 – Paste-Like Polymethylmethacrylate Bone Cement

Patent Status: Pending

Issue Date: N/A

Filing Date: Oct 20, 2008

Inventor(s): Sebastian Vogt, Hubert Buchner

Assignee: Heraeus Medical GMBH

Relation to Art: Claim 16 references biocompatible elastomers

in combination with the bone cement

2.5 10/716,445 – Injectable Bone Substitute Material

Patent Status: Pending

Issue Date: N/A

Filing Date: Nov 20, 2003

Inventor(s): Dirk Johannes Schaefer, Thomas Kiefer, Gerhard

Bjorn Stark, Ulrich Kneser

Assignee: Universitaetsklinikum Freiburg

Relation to Art: Specifically references various matrices used as

a bone healing agent. However, the specific combination of
bone cement and ECM are not present. Also does not
specifically mention bone cement

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2.6 12/473,246 – Injectable Bone/Polymer Composite Bone Void Fillers

Patent Status: Pending

Issue Date: N/A

Filing Date: May 27, 2009

Inventor(s): Scott A. Guelcher, Andrea E. Hafeman, Michelle

B. Brouner

Assignee: Vanderbilt University

Relation to Art: Mentions a polyurethane scaffold (Claim 10) in

conjunction with mineralized bone powder.

2.7 11/407,446 – Bone Graft Composition

Patent Status: Pending

Issue Date: N/A

Filing Date: Apr 19, 2006

Inventor(s): Jerome Connor, Qing-Qing Qiu

Assignee: N/A

Relation to Art: Uses acellular tissue matrix in conjunction with

deminerlized bone as opposed to PMMA in bone cement
specifically.

2.8 11/262,904 – Injectable Soft Tissue Fixation Technique

Patent Status: Pending

Issue Date: N/A

Filing Date: Oct 31, 2005

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 Inventor(s): Michael O'Neil, Alonzo Cook, John Voellmicke

Assignee: N/A

Relation to Art: Specifically mentions combination of ECM

(even SIS) and PMMA, but the over point is for soft tissue
connection, not bone ingrowth.

3. PUBLIC DOMAIN SEARCH

3.1 USC 102(a)

3.1.1
Kneser U, Voogd A, Ohnolz J, Buettner O, Stangenberg L, Zhang YH, Stark GB,
Schaefer DJ:
Fibrin Gel-Immobilized Primary Osteoblasts in Calcium Phosphate Bone
Cement: In vivo Evaluation with Regard to Application as Injectable
Biological Bone Substitute.
Cells Tissues Organs 2005;179:158-169 (DOI: 10.1159/000085951)

Abstract Excerpt:
“Osteogenic injectable bone substitutes may be useful for many applications. We
developed a novel injectable bone substitute based on osteoblast-fibrin glue
suspension and calcium phosphate bone cement (BC).”

3.1.2
Bone Graft Substitute Materials

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 http://emedicine.medscape.com/article/1230616-overview

Excerpt:
The use of allografts for bone repair often requires the sterilization and
deactivation of proteins normally found in healthy bone. Contained in the
extracellular matrix of bone tissue are the full cocktail of bone growth factors,
proteins, and other bioactive materials necessary for osteoinduction and,
ultimately, successful bone healing. To capitalize on this cocktail of proteins, the
desired factors and proteins are removed from the mineralized tissue by using a
demineralizing agent such as hydrochloric acid. The mineral content of the bone
is degraded, and the osteoinductive agents remain in a demineralized bone matrix
(DBM).

3.2 USC 102(b)

N/A

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