Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
The aim of this study was to assess the effect of Magnegita (gadopentetate dimeglumine) on routine
laboratory parameters in patients with impaired kidney or liver function undergoing MRI scans. Seventy-one
patients were included from whom we collected blood samples for three times. Our study showed
statistically significant results for certain parameters at both measurements performed after the injection of
contrast agent. We conclude that monitoring of laboratory values in patients with kidney and liver impairment
after injection of gadopentetate dimeglumine may be helpful by allowing the medical personnel to prevent
serious adverse events.
Keywords: gadopentetate dimeglumine, laboratory parameters, chronic kidney failure, hepatitis C
http://www.revistadechimie.ro
Table 2
REFERENCE RANGES OF THE
STUDIED PARAMETERS
Table 3
ALTERED PARAMETERS AT
BASELINE IN THE TWO
SUBGROUPS
http://www.revistadechimie.ro
809
Table 4
PATIENTS WITH ALTERED
PARAMETERS AT THE SECOND
MEASUREMENT
810
Third measurement
After analysing all the parameters 24 h after the injection
of Magnegita, we have compared the results with those
obtained at baseline and at the second measurement.
Statistically significant results were found for 14 of the
parameters (table 5).
Similarly to the second measurement, all parameters
were altered in most of the subjects. The greatest numbers
of subjects with increased levels, ranging from 60% to 100%
of the subjects, were found in the CKF subgroup (in
descending order): urea, creatinine (both raised in all
subjects), RBC (which was also higher in 60% of the HCV
subjects), HGB, HVT, sodium, chloride, lymphocyte
percentage, monocyte count, and AST. On the other hand,
the highest percentages (between 60 and 72%) of subjects
with decreased levels were recorded in the HCV subgroup,
as follows: chloride, lymphocyte percentage, ALT, urea and
calcium. Compared with the second measurement, five
of the parameters remained increased in over 50% of the
CKF subjects (urea, creatinine, lymphocyte percentage,
sodium and monocyte count), but none of those showing
decreases at the first two measurements. Finally, RBC was
increased in both subgroups at the third measurement,
but not at the second one, when it was decreased in most
of the HCV subjects. Total serum proteins (81%), monocyte
count (67%), lymphocyte percentage, HCT and AST (by
57% each) dropped, but potassium (86%), sodium (81%)
and chloride (67%) increased in more than half of controls.
Monocyte count remained the most altered parameter
as regards the number of patients affected coupled with
the mean rate of change towards baseline in both
subgroups (HCV-14; 62%; CKF-15; 33%), followed by
lymphocyte percentage in the CKF subgroup. The highest
http://www.revistadechimie.ro
Table 5
PATIENTS WITH ALTERED PARAMETERS
AT THE THIRD MEASUREMENT
http://www.revistadechimie.ro
811
812
http://www.revistadechimie.ro