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Consequence
edited by Greet Van den Berghe
Water and sodium homeostasis: mineralocorticoid
and anti -diuretic hormone
Cortisol is required for the functioning of all tissues. It exerts important roles on
cardiovascular function, appetite, and on the immune system, properties that are
particularly relevant in understanding the pathophysiology of adrenal crisis.
CARDIOVASCULAR STABILITY
APPETITE
Glucocorticoids play a central role in glucose metabolism, and regulate
energy storage and utilisation through interaction with the sympathetic nervous
system. An underappreciated effect of glucocorticoids is its potent orexigenic
property ( 14). The appetite stimulating effect of glucocorticoids may involve
mediation by the endocannabinoid system (/5). Both animal ( 16 ) and human (17)
studies have demonstrated an increase in appetite and high -fat food ingestion in