WHAT IS PROTEOMICS

Proteomics is the large-scale study of proteins, particularly their structures and

functions.
Proteins are vital parts of living organisms, as they are the main components of
the physiological metabolic pathways of cells.
The word "proteome" is a blend of "protein" and "genome", and was coined by
Prof. Marc Wilkins (England) in 1994
The term "proteomics" was first coined in 1997 by P. James (Switzerland) to
make an analogy with genomics, the study of the genes.
Proteome
The proteome is the entire complement of proteins, including the modifications made
to a particular set of proteins, produced by an organism or system. This will vary with
time and distinct requirements, or stresses, that a cell or organism undergoes
Why is proteomics?
Proteomics is often considered the next step in the study of biological systems,
after genomics.
It is much more complicated than genomics, mostly because while an organism's
genome is more or less constant, the proteome differs from cell to cell and from
time to time.
This is because distinct genes are expressed in distinct cell types, meaning that
even the basic set of proteins which are produced in a cell needs to be
determined.
mRNA analysis can not give correct answer on the presence of protein in the cell
due to mRNA is not always translated into protein, and the amount of protein
produced for a given amount of mRNA depends on the gene it is transcribed
from and on the current physiological state of the cell.
Proteomics confirms the presence of the protein and provides a direct measure
of the quantity present
Post-translational modifications
Posttranslational modification (PTM) is the chemical modification of a protein
after its translation. It is one of the later steps in protein biosynthesis for many
proteins.
Post-translational modification of Insulin

NEW WORDS
Proteomics
Large-scale:
quy m ln
Particularly
adv
mt cch c bit
Function
n
chc nng
Vital
thuc s) sng, cn cho s sng, Sng cn, quan trng (cn thit
cho s tn ti, s thnh cng..) ,Nguy him n tnh mng,y sc sng, y ngh
lc, sinh ng; nng ng
Organisms
n
c th, sinh vt, c quan, t chc
Component
adj
hp thnh cu thnh
N
thnh phn, phn hp thnh
Physiological:
(huc) sinh l hc; (thuc) cc chc nng ca thn th
Metabolic pathways
nhng con ng chuyn ha
Blend
n
hn hp pha trn
V
pha trn,trn ln, hp nhau (mu sc)
Genome
n
b di truyn
Coin
v
to ra, t ra
Term
n
gii hn
Analogy
v
analogy with something) qu trinh suy lun da trn s ging
nhau; phep loi suy
Genomics
adj
thuc h gen, b gen
Proteome
Complement
n
th b, b th
Modification
n
s sa i, s bin ci
Vary
v
thay i, bin i, khc nhau vi
Distinct
adj
ring bit, d thy, r rng
Undergoes
v
chu ng, tri qua
Complicate
v
lm phc tp, lm rc ri
Constant
adj
ko thay i
Differ from sth
v
khc, khng ging
Express
adj
r rng
Analysis
n
bn phn tch
Transcribe
v
sao chep li
Confirm
v
xc nhn
Presence
n
s hin din, s c mt
Quantity
Post-translational
Biosynthesis
n
s sinh tng hp