Scribd Logo
Carica

Benvenuto in Scribd!

  • Pharmacokinetics and Pharmacodynamics of Midazolam After Intravenous and Intramuscular Administration in Alpacas

    Caricato da

    Kanzell Han
    4 visualizzazioni2 pagine
    Pharmacokinetics and Pharmacodynamics of Midazolam After Intravenous and Intramuscular Administration in Alpacas

    Copyright

    © © All Rights Reserved

    Formati disponibili

    PDF, TXT o leggi online da Scribd

    Hai trovato utile questo documento?

    Questo contenuto è inappropriato?

    Segnala questo documento
    Pharmacokinetics and Pharmacodynamics of Midazolam After Intravenous and Intramuscular Administration in Alpacas

    Copyright:

    © All Rights Reserved
    Scarica in formato PDF, TXT o leggi online su Scribd
    Segnala contenuti inappropriati
    4 visualizzazioni2 pagine

    Pharmacokinetics and Pharmacodynamics of Midazolam After Intravenous and Intramuscular Administration in Alpacas

    Caricato da

    Kanzell Han
    Pharmacokinetics and Pharmacodynamics of Midazolam After Intravenous and Intramuscular Administration in Alpacas

    Copyright:

    © All Rights Reserved
    Scarica in formato PDF, TXT o leggi online su Scribd
    Segnala contenuti inappropriati
    di 2

    3/9/2016

    Pharmacokineticsandpharmacodynamicsofmidazolamafterintravenousandintramuscularadministrationinalpacas.PubMedNCBI

    PubMed

    Format:Abstract

    Fulltextlinks

    AmJVetRes.2013Feb74(2):2949.doi:10.2460/ajvr.74.2.294.

    Pharmacokineticsandpharmacodynamicsofmidazolamafterintravenousand
    intramuscularadministrationinalpacas.
    AarnesTK1,FryPR,HubbellJA,BednarskiRM,LercheP,ChenW,BeiD,LiuZ,LakritzJ.

    Authorinformation
    Abstract
    OBJECTIVE: TodeterminepharmacokineticandpharmacodynamicpropertiesofmidazolamafterIV
    andIMadministrationinalpacas.
    ANIMALS: 6healthyalpacas.
    PROCEDURES: Midazolam(0.5mg/kg)wasadministeredIVorIMinarandomizedcrossoverdesign.
    Twelvehourspriortoadministration,catheterswereplacedin1(IMtrial)orboth(IVtrial)jugularveinsfor
    drugadministrationandbloodsamplecollectionfordeterminationofserummidazolamconcentrations.
    Bloodsampleswereobtainedatintervalsupto24hoursafterIMandIVadministration.Midazolam
    concentrationsweredeterminedbyuseoftandemliquidchromatographymassspectrometry.
    RESULTS: MaximumconcentrationsafterIVadministration(median,1,394ng/mL[range,1,150to1,503
    ng/mL])andIMadministration(411ng/mL[217to675ng/mL])weremeasuredat3minutesandat5to
    30minutes,respectively.Distributionhalflifewas18.7minutes(13to47minutes)afterIVadministration
    and41minutes(30to80minutes)afterIMadministration.Eliminationhalflifewas98minutes(67to373
    minutes)and234minutes(103to320minutes)afterIVandIMadministration,respectively.Total
    clearanceafterIVadministrationwas11.3mL/min/kg(6.7to13.9mL/min/kg),andsteadystatevolume
    ofdistributionwas525mL/kg(446to798mL/kg).BioavailabilityofmidazolamafterIMadministration
    was92%.Peakonsetofsedationoccurredat0.4minutes(IV)and15minutes(IM).Sedationwas
    significantlygreaterafterIVadministration.
    CONCLUSIONSANDCLINICALRELEVANCE: MidazolamwaswellabsorbedafterIMadministration,
    hadashortdurationofaction,andinducedmoderatelevelsofsedationinalpacas.
    PMID:23363357 DOI:10.2460/ajvr.74.2.294
    [PubMedindexedforMEDLINE]

    PublicationTypes,MeSHTerms,Substances
    LinkOutmoreresources

    http://www.ncbi.nlm.nih.gov/pubmed/23363357

    1/2

    3/9/2016

    Pharmacokineticsandpharmacodynamicsofmidazolamafterintravenousandintramuscularadministrationinalpacas.PubMedNCBI

    PubMedCommons

    PubMedCommonshome

    0comments
    HowtojoinPubMedCommons

    http://www.ncbi.nlm.nih.gov/pubmed/23363357

    2/2

    Potrebbero piacerti anche