EFFECT PHYTOESTEROGEN OF SOY ISOFLAVON ON REPRODUCTIVE HORMONES IN

MEN : A SYSTEMATIC REVIEW

Rini Mulyawati
Faculty of Pharmacy, Ahmad Dahlan University Yogyakarta
Correspondence:
Rhiny.mulyawati@gmail.com

91

Abstract
Background: Soy contain isoflavones compounds with phytoesterogen activity. Phytoesterogen had a similar effects with hormone estrogen. From the research in men, it is
known that phytoeserogen can decreased concentration of hormone testosterone, but in the other study phytoesterogen had not effect on testosterone concentrations. So it is
unclear how phytoesterogen influence on reproductive hormones in men.
Objective : This study aimed to determination effect of soy consumption on reproductive hormones in men.
Methods / Design : To review the scientific data that met the inclusion criteria. The scientific data obtained through PubMed and Google scholar databases using P =
Phytoesterogen in men , I = Soya , isoflavones , genistein , soy protein , C = Placebo , Meat diet , O = Reproductive hormones , Testosterone , Sex Hormone Binding Globulin
( SHBG ).
Outcome : The effect of soy consumption on the concentration of testosterone and Sex Hormone Binding Globuline ( SHBG ) in men.
Results : Analyzed effect of consumption soy isoflavone in the six study in humans, only one study showed a decrease of testosterone concentration, while the five journal showed
no effect on testosterone, and from two study in animals showed a decrease testosterone concentration. In addition analyzed six study in humans, just the one study showed a
decrease of SHBG levels, but the others study doesnt significant effect of soy isoflavone intake.
Conclusion : Consumption of soy isoflavone compounds doesnt significant effect on the concentration of testosterone and SHBG. In conclusion soy consumption doesnt side
effects associated with changes in reproductive hormones in men.
Keywords: Phytoesterogen, Soya, isoflavon, genistein, Reproductive hormones, men
Title

Author

Soy Protein Isolates of D i l l i n g Varying Isoflavones ham et al.,

Content Exert Minor 2005
Effect on SerumReproductive Hormones
in Helthy Young Men

Dietary
soyphytoesterogens decrease testosterone
levels and prostate
weight without altering LH, prostate 5reductase or testicular
steroidogenic acute
regulatory peptide
levels in adult male
sprague dawley rats
Effect of protein
source and resistance
training on body composition and sex hormones

Methode and Sample Lenght

Methode: Randomized 57 days
Crossover Design
Sample: Men 20-40
years, consumption milk
protein
isoflavone
(MPI), low soy protein
isoflavone (SPI-), and
high soy protein isoflavone (SPI+)

Weber et Methode: Experimental 35 days

al., 2001
in vivo
Sampel: 114 adult male
Sprague-dawley (50
day), randomized consumption (1) phyto free
diet, (2) phyto rich containing diet

SHBG
A decline in testos- No significant change in
terone levels on day 29 consumption of soybeans
in the group SPI- and in each group .
on day 57 in the MPI
group , but did not differ significantly among
the three groups .
Therefore concluded
there was no significant
effect on serum testosterone after administration of soy
The concentration of
testosterone in the animals ( rats ) were given
phytoesterogen had
lower levels than those
not given phytoesterogen .

Kalman et Methode: Randomized 1

2 Supplementation of soy
for 12 weeks there was
al., 2007
control trial
weeks
no significant difference
Sample: 20 subjects
in testosterone concenhave a treatment for 12
trations between 4 exweeks, with 50 g/day
perimental groups , and
sample (soy concendid not lower the value
trate, soy isolate, mixof the concentration of
ture of soy isolate and
testosterone
whey, and whey)

Isoflavones Rich soy Hamilton- Methode: Randomized 6

protein isolate sup- Reeves et single blind parallel de- months
presses androgen re- al., 2007
sign
ceptor
expression
Sample: 58 men, 50-85
without altering estroyears, randomized trial
gen receptor exwith sample are (1) high
pression or serum horprotein
isoflavone
monal profiles in men
(SPI+), (2) low protein
at high risk of prostate
soy isoflavone (SPI-), (3)
cancer
milk protein isoflavone
(MPI)
The effect of soy and K r a e m e r Methode: Randomized 14 days
whey protein supple- et al., 2013 Crossover
mentation on acute
Sample: men 21,7
hormonal responses to
years, gives supplemenresistance exercise in
tations whey protein
men
isolate(WPI), soy protein isolate (SPI), and
placebo (maltodextrin)

OUTCOME

Result

No significant difference
of serum testosterone
concentrations after
consumption of soy and
no significant difference
between SPI + , SPIand MPI .

No significant effect on
the administration of soy
supplementation in each
group and between
groups for 12 weeks in
SHBG

There was a decrease in

SHBG levels significantly
when compared with before treatment , but no
difference between SPI
+ , SPI- , and MPI

Giving soybeans for 12 There was no difference

days did not affect se- in SHBG values on the
rum testosterone values provision of treatment
were significantly

Conclusion
Consumption of soy isoflavone compounds doesnt significant effect on the concentration of testosterone and SHBG. In conclusion soy consumption doesnt have side effects associated with
changes in reproductive hormones in men.
Refference

RESULT
Title

Author Methode and Sample

Effects of replacing meat with

soyabean in the
diet on sex hormones concentrations
in
healthy
adult
males
Effects of soybean isoflavones
on reproductive
parameters
in
Chinese mini-pig
boars

H a b i t o Methode: Randomized 4 weeks

et al., Crossover Design
2000
Sample: Men 35-63 years,
consumptions 290 g tofu/
day compare with 150 g
raw meat/day

Dietary supplements of soya

flour lower serum
testosterone concentrations and
improve markers
of oxidative stress
in men

Lenght

Yuan et Methode: Randomized 60 days

al., 2012 design
Sample : a 50 pigs 28
days, gives supplementations based of mays, soy
isoflavones, and diethylstilbestrol.
T h o r p e Methode: Randomized 6 weeks
et al., Crossover Design
2003
Sample: subject consumption soya flour 120 mg/
day

Result
T
No significant differences in serum testosterone
values
between giving Tofu
compared to raw
meat

SHBG
There is no significant
difference between
serum SHBG values
between giving tofu
compared to raw
meat .

Giving high doses of

isoflavones lowers serum testosterone in
the test animals

Value of serum testosterone volunteers who

consumed soy is lower
than the value of serum testosterone before treatment .

No significant differences in SHBG values

before and after consumption of soy

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