Age

BRCA1

HER PR
2/ne
u
-

BRCA2

LCIS

Luminal PM
A (NST)

Luminal
B (NST)

++

Normal
breast
like
(NST)
Basal
(NST)

HER2+
(NST)
(Paget
cancer)
Invasiv
e
lobular

ER

Young wome
n
-

Distinct histology

BRC
A1

Basal-like phenotype

Grad
e

Prolifera
tive rate

Mets

High
grade
M-H
grade

Mucin + signet cells,

E-cadherin E3 gene profile, well
diff.

Mode
rate

Low

Triple positive cancer

High

High

LN
increas
ed risk

Similar gene profile

as normal tissue

Myoepithelial cell
markers

LowMod
(well
diff.)
High

High

High brain

High

High

High

Palpable mass with

Irregular borders
(3/4) Or

Prognosis

+
(ofte
n)

Low

See
below

Good response to
hormonal therapy;
poor response to
chemo
Standard chemo

Poor unless
chemosensitive
(15%)
??
Sensitive to
herceptive (but still
rsik of brain mets)
May have a greater
incidence of
bilaterality

 Well
differen
tiated

Invasiv
e
lobular
poorly
differen
tiated
Medulla 6th
ry
decad
e

Diffusely infiltrative
tumour with little
desmoplasia (1/4)

Dyscohesive
Mucin + signet cells
E-cahderin (CDH1
LoE)
Minimal desmoplasia
Luminal A gene
profile LCIS
association
Aneuploidy

Little desmoplasia
soft, fleshy, well
circumscribed
Aneuploidy
Pleomorphic nuclei
E-cadherin ++
Basal like gene
expression
Pushing margins
lymphocytic
response

High

+
High
(2/3r
ds
have
BRCA
1
hype
rmet
hylat
ion)
Abse
nce
of

Aggressive

High

LN
mets
uncom
mon

Better than NST

carcinomas despite
presence of poor
prognostic factors
like high nuclear
grade, aneuoploidy,
absence of hormone
receptors and high
proliferative rates

barr
body
Mucinu
ous/
Colloid

71
yrs

Tumour is
soft/rubbery
Consistency and
appearance of paleblue gelatin
Tumour cells are
arranged in clusters
and small isalnds of
cells within large
lakes of mucin
Pushing borders

Low

Tubular

Late
40s

Small (<1cm),
Multifocal tumours
Consist exclusively of
well-formed tubules
Absent myoepithelial
cells
Cribriform
Luminal calcification
Associated with aLH,
LCIS, DCIS

Low

Invasiv
e
papillar
y
carcino
ma
Invasiv
e

Low

LN
mets
uncom
mon

Axillary
LN
mets
uncom
mon

LN
mets
uncom
mon
+

LN
mets

Better than NST

microp
apillary
carcino
ma

commo
n

Invasive lobular carcinomas have different pattern of mets compared to other breast cancers:
Peritonieum & retroperitoneum
Leptomeninges
GIT
o Maybe mistaken for signet ring carcinomas of GIT
Ovaries (Krukenberg) & uterus