The gameplay of Ms. Pac-Man very similar to that of the original Pac-Man.

The player earns points by eating pellets and avoiding ghosts

Eating an energizer causes the ghosts to turn blue, allowing them to be eaten fo
r extra points.
Bonus fruits can be eaten for increasing point values, twice per round.
As the rounds increase, the speed increases, and energizers generally lessen the
duration of the ghosts' vulnerability, eventually stopping altogether.
There are also some differences from the original Pac-Man:
The game has four different mazes that appear in different color schemes, and
alternate after each of the game's intermissions are seen.
Three of the four mazes (the first, second, and fourth ones) have two sets of wa
rp tunnels, as opposed to only one in the original maze.
The walls have a solid color rather than an outline, which makes it easier for a
novice player to see where the paths around the mazes are.
The ghosts' behavioral patterns are different, and include semi-random movement,
which prevents the use of patterns to clear each round. Blinky and Pinky move r
andomly in the first several seconds of each level, until the first reversal. In
ky and Clyde still use their same movement to their respective corners, again un
til the first reversal.
Instead of appearing in the center of the maze, the fruits bounce randomly aroun
d the maze, entering and (if not eaten) leaving through the warp tunnels. Once a
ll fruits have been encountered, they appear in random sequence for the rest of
the game, starting on the eighth round; this means that a 5000-point banana can
be followed by a 100-point pair of cherries, and vice versa.
The orange ghost is called Sue, rather than Clyde; her color was later changed t
o purple in Pac-Land to differentiate her.
When Ms. Pac-Man makes contact with a ghost and dies, she spins around rather th
an folding in on herself like the original Pac-Man did.
The three intermissions have changed to follow the developing relationship betwe
en the original Pac-Man and Ms. Pac-Man (from when they first meet to having a s
tork drop off their baby); the latter later served as the attract opening sequen
ce for Jr. Pac-Man.
The sound effects and music are very different from those of the original game,
including a new opening theme and death sound effect.
As with Pac-Man, this game has a bug in the subroutine that draws the fruit, whi
ch renders the 256th round unplayable. However, the game also has other bugs tha
t cause it to crash or become unplayable much sooner, making it impossible to re
ach Round 256 without the use of emulation.