Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
Chemical
N-acetyl-
structure of the
paminophenol
drug
Non proprietary
Generic name
acetaminophen
Trade name or
Tylenol
1. Pharmacy
involved in the compounding, preparation,
collection, standardization and dispensing of the
drug.
2. Pharmacognosy
recognize the drugs (description, sources, chemical
composition, nature of doing, etc)
study of the physical and chemical properties of the
drugs with the description and identification of
their sources and nature.)
3. Biochemorphology
(structure activity relationship or SAR)
how the chemical structure of the drug is related to
physiological, biological and biochemical effects.
endogenous catecholamines
(isoproterenol)
ephedrine
acting sympathomimetic
symp
agent; CNS
mixed-acting
stimulation; not a catecholamine but its effects on
bronchi and other smooth muscles are
quantitatively similar to those of epinephrine
amphetamine
acts indirectly by releasing norepinephrine; also a
name
Proprietary name
brand name
BRANCHES OF PHARMACY
4. Toxicology
- study of the harmful effects of drugs and other
chemicals on human, animals and plants
5. Posology
- deals with the dosage of the drug required to
produce a therapeutic response
6. Molecular Pharmacology
studies the mechanism of
enzymatic level (gene therapy;
engineering)
action of a drug at
genetic
7. Developmental Pharmacology
- deals w// drug given to mother as it affects the
fetus during natal, prenatal,
perinatal &
neonatal periods.
8. Pharmacogenetics
- studies the influence of heredity on
the
pharmacokinetic and pharmacodynamic response
of the drug.
9. Pharmacogenomic
- describes the use of genetic information to guide
the choice of drug therapy on an individual basis
10. Pharmacoepidemiology
PURPOSE
establish safety
Establish efficacy and dose
Verify efficacy and detect ADRS
Obtain additional data following approval
I
ANIMAL
TESTING
Pre-clinical
testing
12. Ethnopharmacology
PHASE
drugs (ESSC
II
FDA
III
CLINICAL
TESTING
Cost
Phase II
Phase III
Absorption
Distribution
Metabolism (biotransformation)
Excretion
15. Pharmacodynamics (dynamic = drugbody)
- what the drug does to the body
- biochemical and physiological effects
of drugs
and their mechanism of action
(includes enzymatic or molecular level and also
toxicological or adverse effects.)
IV
New Drug
Application
(NDA)
- Review (BFAD)
- Marketing approval
V.
Post
Marketing
Surveillance
(PMS)
AntacidVasodilator
Pharmaceutical phase
(bioavailability)
(disintegration and dissolution)
Pharmacokinetic Phase
(ADME)
Pharmacodynamic phase
(drug-cell, drug-receptor, drug-drug interactions;
individual sensitivity; pathological conditions)
Effects
(toxic, therapeutic, subtherapeutic)
PHARMACEUTICAL PHASE
involves disintegration of dosage form (generally
water soluble) & dissolution
of active
ingredients (lipid soluble)
Bioavailability
fraction of unchanged drug reaching the systemic
circulation following administration by any route
PHARMACODYNAMIC PHASE
Drug-drug interaction
simultaneous intake of two different drugs, one drug may
displace another for Its binding site
another may reduce the metabolism of the other
Individual sensitivity interpatient variability (for
hyperactive and hypoactive people.
Pathological conditions renal, cardiac, hepatic
dysfunctions, malnutrition
Science of drug interactions between living systems & molecules introduced from outside
the system
The measure of the apparent space in the body available to contain the drug .
The measure of ability of the body to eliminate the drug
Is the time required to change the amount of drug in the body by one half during
elimination
-t1/2
LOADING DOSE
MAINTENANCE DOSE
PEAK AND THROUGH
LEVEL OF DRUGS
PHARMACODYNAMIC
EFFICACY
POTENCY
AFFINITY
AGONIST
PARTIAL AGONIST
MEDIAN EFECTIVE DOSE
THERAPEUTIC INDEX
RECEPTOR/SPARE
RECEPTOR
TOLERANCE
TACHYPHYLAXIS
OVERSHOOT OR REBOUND
PHENOMENOM
UP/DOWN REGULATION
IDIOSYNCRASY
PLACEBO/PLACEBO
RESPONSE
CLINICAL
PHARMACOLOGY
XENOBIOTICX
PHARCOEGENOMICS