Documenti di Didattica
Documenti di Professioni
Documenti di Cultura
paediatric
antimalarial medicines
UNICEF Supplier Meeting
21 October 2008, Copenhagen, Denmark
Silvia Schwarte
Global Malaria Programme
Outline
Burden of disease
Market situation, funding
Requirements for children medicines
Prequalification
Monotherapy
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GLOBAL
MALARIA PROGRAMME
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GLOBAL
MALARIA PROGRAMME
GLOBAL
MALARIA PROGRAMME
Forecast
180
80
160
160
70
140
130
120
50
97
100
82,7
40
80
30
60
40
20
31,3
10
20
0,5
0,6
2,1
0
2001
2002
ACT procured
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60
2003
2004
2005
2006
2007
2008
2009
No countries deploying
GLOBAL
MALARIA PROGRAMME
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GLOBAL
MALARIA PROGRAMME
Successful applications
to Round 6 and 7 of GFATM
900
800
700
600
500
400
300
200
100
0
Millions USD
Round 6
Round 7
Phase I Phase II
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GLOBAL
MALARIA PROGRAMME
GLOBAL
MALARIA PROGRAMME
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GLOBAL
MALARIA PROGRAMME
GLOBAL
MALARIA PROGRAMME
Suppositories
- heat stability
- rectal absorption
- cultural issues
- pre-referral treatment
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GLOBAL
MALARIA PROGRAMME
Brand name/manufacturer
Preservative
Active ingredient/dose
Content
stable*
Efficacy test
Sorbic acid
conforms
Methylparaben
failed
conforms
failed
Not conforms
failed
Not conforms
Propylparaben
Artesiane , Dafra Pharma, Belgium
Methylparaben
Propylparaben
Methylparaben
Propylparaben
Benzoic acid
Not conforms
Benzoic acid
Not conforms
Chlorbutanol?
No content
Not conforms
* preservative completely and immediately dissolved and levels unchanged during 7 days
preservative efficacy test against P. aeruginosa, S. aureus, E. coli, C. albicans, Z. rouxii, A. niger
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GLOBAL
MALARIA PROGRAMME
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GLOBAL
MALARIA PROGRAMME
Co-blister
Fixed-dose
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GLOBAL
MALARIA PROGRAMME
- Artesunate + Amodiaquine
- Artesunate + Mefloquine
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GLOBAL
MALARIA PROGRAMME
* Artesunate tablets to be used only in combination with either Amodiaquine, Mefloquine or Sulphadoxine + Pyrimethamine
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GLOBAL
MALARIA PROGRAMME
60
Substandard
medicines?
50
40
Not yet contacted
No intention disclosed
Intention to comply
30
20
10
0
Identified
in2005
17 |
Identified in
2006
Identified in
2007
Identified in
2008
GLOBAL
MALARIA PROGRAMME
Thank you
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GLOBAL
MALARIA PROGRAMME