MicB 4151

Molecular and Genetic Basis of Microbial Pathogenesis

Spring 2016
Professor Wade Bresnahan: Microbiology Research Facility (MFR) 1-111
E-mail bresn013@umn.edu
Phone: 626-5876
Lecture: MW 4:00 pm5:15 pm, Room Jackson Hall 2-137
Course materials available on Moodle
Office hours for Dr. Bresnahan: by appointment only, schedule by email (preferred) or phone
Textbook (required): Schaechters Mechanisms of Microbial Disease, 5th edition.
Lecture

Date

Topic

1/20

Genetic Plasticity of Pathogens

Course Intro; Emerging infections

1/25

Antibiotics: mechanisms and resistance

1/27

Plasmids, mobility of virulence genes, quorum

sensing

2/1

2/3

2/8

2/10

2/15

2/17

10

2/22

11

2/24

12

2/29

13

3/2

14

3/7

15

3/9
3/14
3/16

Reading

Bresnahan
Chapters 3, 5,
and 30
Chapter 57
p560-566 and
Online reprint

Discovery of virulence genes: genetic screens and

Chapter 4
selections in vivo gene expression technologies
Bacteriophages and mobility of virulence genes:
Chapter 16
Vibrio cholerae and the disease cholera
Colonization of Hosts and Tissues
Chapter 2 and
Human microbiota:
p236-237
Adhesins and infection specificity - pathogenic
Chapter 16
Escherichia coli
Mucosa or Blood Salmonella gastroenteritis
Chapter 17
versus typhoid fever
Biofilms and Type III Secretion Pseudomonas and
Chapter 22,
Helicobacter
Chapter 18
Exam I
Bacterial Toxins
Adenyl cyclases & ADP-ribosylating toxins:
Diphtheria, cholera, and pertussis
Clostridium species and their toxins

Lecturer

Chapter 9,
Chapter 19
Chapter 20
and p756-757

Staphylococcus aureus - superantigens and cytolytic

Chapter 11
toxins
Avoidance of Immune Responses
Innate and Adaptive Immune Response
Chapter 6 & 7
Viral Avoidance of the Immune Response Chapter 42
Cytomegalovirus
Spring Break
Spring Break

Thiede
Dale
Dale
Aagesen

Hunter
Brickman
Brickman
Mohr

Armstrong
Armstrong
Armstrong
Bresnahan
Bresnahan

MicB 4151
Molecular and Genetic Basis of Microbial Pathogenesis
Spring 2016
16

3/21

17

3/23

18

3/28

19

3/30

20

4/4

21

4/6

22
23
24

4/11
4/13
4/18

25

4/20

26

4/25

27

4/27

28

5/2

29

5/4

Streptococcal pathogenesis

Chapter 12
Chapter 13,
Capsules production and bacterial meningitis
Chapter 14,
Streptococcus pneumoniae, Haemophilus
Chapter 61:
influenzae, Neisseria meningitidis
p612-615; 618621
Chapter 14,
Antigenic variation: gonorrhea and syphilis
Chapter 24
Vector-borne and Respiratory Diseases
Exam II
p 566-567 and
Yersinia pestis: fleas and plague
On-line reprint
Antigenic shift Lyme disease, relapsing fever and
Chapter 25
other spirochetes
Respiratory Viral Infections
Team Presentations in class
Team Presentations in class
Intracellular Invasion and Host Cell Manipulation
Chapter 21,
An Obligate Intracellular life style Legionella,
Chapter 27,
Chlamydia and Rickettsia
Chapter 28
Invasion of the mucosal epithelium Shigella and
Chapter 17,
Listeria
On-line reprint
Mycobacterial infections: tuberculosis, survival in
Chapter 23
macrophages
Pathogenic Fungi
Chapter 46,
Properties of fungi, pathogenic yeast and antibiotic
Chapter 50,
therapy
Chapter 48
Chapter 47,
Cryptococal infections,Skin mycoses, systemic
Chapter 48,
mycoses
Chapter 49
th
Cumulative Final Exam Monday May 9 4pm-6pm
2-137 Jackson Hall

Armstrong

Armstrong

Brickman

Aagesen
Thiede
Fiege
Bresnahan
Bresnahan

Brickman
Brickman
Baughn

Davis

Okagaki