RESULTS

Help in
INTERPRETATION

E.I.S-01-USB System
Electro
Interstitial
Scan
Electrical Bio Impedance Analysis
Tissue and microcirculation

Manufacturer, Specification
developer: SOFTMED Technology
4,rue de la Presse,
1000-Brussels- Belgium

Medical device. Class 2 a

1

RESULTS AND INTERPRETATION

Electro Scan Gram: (ESG)

The Electro Scan Gram (ESG) is a graph of the conductivity values
measured in 3 steps by the EIS system
The EIS system uses a software to control, coordinate, and direct three specific preprogrammed sequences (1 A.C. & 2 D.C.) of brief, barely perceptible current pulses through
an array of 6 symmetrically placed surface electrodes: left & right forehead, left & right hands
(palms), and left & right feet (soles).
This 6-electrode array forms 22 electrode pairs, or volumes (see Table 2, on the folder
background of EIS system). The term volume refers to the 3-dimensional anatomical
space that lies between each electrode pair.
The conductivity values measuring by EIS system will be displayed in numerical forms on a
scale of +100 to 100 for each of the 22 volumes. We call this graphic an Electro Scan Gram
or ESG.
Initially, the conductivity (C) is in numerical forms on a scale from 0 to +100 (absolute
1
values).
These absolute values for conductivity are converted to the +100 to -100 ESG scale by the
determination of 2 quantities: items 0 N and item 0 A..
2
Item 0 N
Item 0 for the measurement N is determined by an empirically-derived coefficient related to
the age, height, weight, and the gender of the subject.
Item 0 A
Item 0 for the measurement A is determined by the arithmetic average of measurements of
absolute values.

Table 1 : EIS Procedure Involves 3 Consecutive Pulse Sequences*

Step

Duration of
each pulse
1s

Number of
pulses
24

localisation

Purpose(s)

Type of pulse
sequence
AC

Graph 1 in

DC

1s

22

DC

3s

22

Graph 1 in
blue
Graph 2 in
yellow(N1)
and in Red
(A1)
Graph 1 in
yellow
Graph 2 in
braun(N3)
and in green
(A3)

1.Body composition
2.Improved signal-tonoise ratio in subsequent
D.C measurement
Interstitial conductivity
measurement

Interstitial biochemical
analysis

Measurement 1: The A.C. pulse sequence occurs first. Each of the 6 electrodes pairs
(from this point on called volumes) receives a 1 second A.C. pulse of electricity at 5 Hz,
50 kHz and 200 KHz frequency at 800 A current. This 1 second A.C. pulse has 2
purposes. The first is to determine body composition (BIA), much like the typical
commercial A.C. BIM devices. The second reason to start with the A.C. pulse is that it

has been observed that D.C. impedance readings have less noise when preceded by an
A.C. pulse32.
The 2 sets of D.C. pulse sequences are identical in tension at 1.28 V D.C.
However, the1st D.C. set sends 1-second duration pulse of electricity through each of the
22 volumes of the sequence, while the 2nd D.C. set sends a 3-second duration electric
pulse.
The D.C. voltage is measured at each volumes cathode is then fed into the P.C. for
analysis. For practical reasons, the voltage data is expressed as conductivity which is
the inverse of electrical resistance. The reason there are 2 D.C. sets of pulse sequences is
to provide the maximum and the minimum conductivity values for each tissue volume.
The 1st D.C. set generates the maximum conductivity values because a 1-second electric
pulse is too brief a time to permit significant electrical current decay to occur.
Measurement 2: This 1st D.C set is used to determine the interstitial conductivity values
and the results for the modeling.
Measurement 3: In contrast, after 3 seconds, substantial loss of electrical energy has
occurred. The electrical pulse energy weakens at a rate of 1/t, where t = time (Cottrell
equation or chronoamperometry).
This 2nd DC set is used to determine interstitial biochemical values.

Reference values
A series of preliminary clinical studies of D.C. BIM using the EIS device were
carried out in France and Russia several years ago.32 During the clinical investigations,
the control groups of healthy subject were tested to generate a normative data base for the
EIS results. The Figure below, illustrates the composite ESG graphic from the normative
database.

pat1
pat2

150

pat3
pat4
pat5
pat6

100
50

pat7
pat8
pat9
pat10

0
-50
-100
-150
4

11

13

15

16

19

21

pat11
pat12
pat13
pat14

If you click on the icon RV, you can compare the reference values and the ESG patient

ESG of the patient

ESG Reference values

This icon determines the Fast Fourier Transformation of ESG graph (55) (56)
This transformation is made for simplified the calculations of algorithms and therefore
the interpretation

This icon allows visualising the values of all the 22 measurements:

In absolute value (scale 0/100)
For the AC measurement (AbsAC), the DC 1 second per volume (Abs1) and DC
3 seconds per volume (Abs3)

In ESG values (scale 100/-100) for the DC 1 second per volume (N1/A1) and DC 3 seconds
per volume (N3/A3)

Help in Interpretation in ESG graph: The ESG graph do not require interpretation, all the
following results are the analysis of the ESG graph. The ESG graph was used as a reference
or criteria of judgment of the clinical investigations.

Modeling
Modeling Process
These images are synthesized images made by a modeling process and derived from
mathematical algorithms of both direct and inverse problems. For each organ, there are 8
steps to the process as illustrated below.

Modeling
2

S
T
A
T
I
S
T
I
C
A

3
5
4

Chromatology conventions and scale of values

The measurement of conductivity on the level of the localized organs makes it possible to
carry out modeling images according to a chromatology corresponding to the measurement of
conductivity.

Scale of colours used for conductivities. The colour on the left corresponds to a null
conductivity (min=0). The colour on the right has the most significant conductivity for the
image considered.
In all the modeling images, one represents the value of conductivity treated according to a
value between - 100/+100

In all the modeling images:

Run the cursor over the images; at the top of the modeling window, you will see the value (in
scale +100/-100) of the organs corresponding to the conductivity (see chromatology)
Right clicking with the mouse on any organ, will visualize the corresponding parameters
linked with the conductivity of this organ
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Organic EIS Modeling Example

In this modeling example you can see the estimated functions of the Right lobe of the liver,
from a scan recording done by the EIS system.

Heart EIS Modeling Example

Brain EIS Modeling Example

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Neurovegetative system effects EIS Modeling Example

1
The modeling of the neurovegetative system
effects does not visualise the organs but
rather the effects of sympathic and
parasympathic system on the organs. These
effects are also estimated in the scale 100/100.

Segmental muscular excitability EIS Modeling Example

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Spine EIS Modeling Example

1

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The analysis list Icon

Click on this icon, and the entire listing of the organs and vertebra will open. When you click
on any organ in the listing, you will see at the bottom of the listing, the Intracellular ph
(icpH) ,the interstitial ph(ipH) and the interstitial Intensity (iI) of this organ or vertebra.
The whole list and values can be copied and pasted into the doctor's conclusion.
Warning: When the analysis list is open, direct reading on modeling with the mouse is not
possible

This icon makes it possible to turn the images in all the directions, and to
zoom in or out on the organs, as well as to move the modeling image up
or down within the modeling window.

This table allows to make adjustment of temperature, to

aggravating or reduce the chromatology and to visualise the
origin of the dysfunction

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Help in Interpretation in the results of modeling:

Interpretation of the different parts of the modeling:
The values are
1. In scale 100/ -100: The reference values are 20/-20
< -20 and > -59 in blue:
-20 to -30: Mild:
o Chronic inflammation (tissue)
o Excitability reduced (brain, muscles)
o Osseous density reduced (spine)
o Pressure reduced (vessel)
o Inhibitor effect (A.N.S)
-31 to -59: Significant
o
o
o
o
o

Chronic inflammation (tissue)

Excitability reduced (brain, muscles)
Osseous density reduce (spine)
Pressure reduced (vessel)
Inhibitor effects (A.N.S)

< -60 in dark blue: Strong

o
Degenerative process (tissue)
o
Excitability reduced (brain, muscles)
o
Osseous density reduce (spine)
o
Pressure reduce (vessel)
o
Inhibitor effects (A.N.S)

20 and < 59 in yellow

< 30: Mild:
o acute inflammation (tissue)
o Excitability increased (brain, muscles)
o Blocking part in spine (spine)
o Pressure increased (vessel)
o Stimulating effects (A.N.S)
> 31: Significant
o acute inflammation (tissue) and pains
o Excitability increased (brain, muscles)
o Blocking part in spine (spine)
o Pressure increased (vessel)
o Stimulating effects (A.N.S)

> 60 in red: Strong

o Acute inflammation and possibility of necrosis (tissue) and
pains
o Excitability increased (brain, muscles)
o Blocking part in spine (spine)
o Pressure increased (vessel)

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2. In physiologic tissue and microcirculation : indicated with the norms and units of
measurement
You can see all these parameters on the folder specifications table 1, 2 and 3 related
with the chromatology and the scale 100/-100
Brain Modeling:
1. Frontal lobes are the zone of the thought.
o < -30=> Depression, fatigue
o > 30 => Insomnia, behaviour disorders
2. The limbic systems are the zone of emotions
o < -30=> Emotional disorders
o > 30 => hyperactivity, lack of concentration, aggressively
3. The amygdalas are the zone of anguish or phobia
o < -30=> Anguish
o > 30 => Phobia
Unilateral unbalance:
o In the right the disorders is recent
o In the left: the disorder is old
Heart Modeling
1. Ventricles
o < -30=> Reduced cardiac pump activity
o > 30 => Hypoxia
2. Vessels
o < -30=> Reduced pressure
o > 30 => Increased pressure
3. Coronary
o > 20 => circulatory disorders in the coronary ( atherosclerosis, thrombus, high blood
viscosity)
4. Baroreceptor reflex
o > 20 => hypertension
5. Heart rate
o > 85 => Tachycardia
o < 60 => Bradycardia
Digestive system Modeling
1. Colons
o < -30=> chronic inflammation
o > 30 => acute inflammation
2. Stomach
o < -30=> chronic inflammation
o > 30 => acute inflammation
3. Liver
o < -30=> chronic inflammation , side effects of drugs
o > 30 => acute inflammation , increased cholesterol production
4. Pancreas
o < -30=> chronic inflammation and reduced insulin production
o > 30 => acute inflammation, increased insulin production and triglycerides

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Urogenital and renal Modeling

1. Kidney
o < -30=> kidney function reduced
o > 30 => interstitial nephropathy
2. Bladder
o < -30=> chronic inflammation
o > 30 => acute inflammation
3. Prostate
o < -30=> hypertrophy or possibility of degenerative process
o > 30 => hypertrophy or acute inflammation
4. Uterus
o < -30=> chronic inflammation or menstruation
o > 30 => acute inflammation or ovulation
Respiratory system Modeling
1. Lungs
o < -30=> chronic inflammation or hyperventilation
o > 30 => acute inflammation or hypoventilation
2. Trachea and Bronchi
o < -30=> chronic inflammation
o > 30 => acute inflammation
Thyroid Modeling
o < -30=> hypo activity see the value of TSH in estimation interstitial hormone
o > 30 => hyperactivity see the value of TSH in estimation interstitial hormone
Thymus Modeling
o < -30=> Immunity reduced
o > 30 => Immunity increased ( auto immune disease possibility)
Spine Modeling
o < -30=> osseous density reduced
o > 30 => pains , blocking zones or deformations
Muscular excitability Modeling
o < -30=> somesthesia disorders
o > 30 => pains or lactic acid
The EIS system modelizes the vertebral column indicating zones of least mineralization (blue)
and the zones of articular blockage and vertebral dislocation (yellow).
The EIS system also modelizes segmental muscular excitability permitting the localization of
painful muscular zones (yellow) or zones presenting pain of somesthesia (blue).
. Neurovegetative or Autonomic Nervous System (A.N.S) effects Modeling
o < -30=> Inhibiting effects
o > 30 => Stimulating effects

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Statistical functional risk analysis:

This graph represents a statistical analysis of the functional risks of the various systems.
Functional risk
Icon
Respiratory functional risk

Digestive functional risk

Immune functional risk

Renal and urogenital functional risk

Neuro muscular functional risk

Cardiovascular functional risk

Endocrine functional risk

Neurological functional risk

Metabolic general functional

This Statistical Functional Risk analysis results from the application of the mathematical
algorithms of the inverse problems made from all the clinical testing & investigations. All
these algorithms were integrated into a statistical program (Statistical version 7.0). This
program is on EIS software.
The main risk is I the associated risks with II, III or IV. Click on any of the branches showing
a risk, and a window will open listing the possibilities of the risk as related to the system.

17

While you click on the risk, the window indicates the possibility of dysfunction or disease
according to specificity and sensitivity statistical calculations, and the software automatically
zooms on the particular system being studied.

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Left Click with the mouse to see the vertebra and

Right Click on the mouse to see the segmentary muscular
excitability

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This icon:

Give access to the graphics with the list of organs and tissues and blood parameters

Help in interpretation for the statistical risk analysis

DISCLAIMER! According to the results of the tissue parameters, microcirculation and
inverses problems, issues from clinical tests the software propose some possibilities of
diseases or dysfunction with a specificity and a sensitivity. These possibilities are not
diagnostic, but help to regulate more specific and sensitive supplementary examinations.
These possibilities are not available for a patient under medications (drugs or chemotherapy,
radiotherapy, surgery). In this case the statistical functional risk analysis is a follow up of
effects of these therapies.
The risk I is not obligatory significant, it can be sometimes mild dysfunction.
The risk will be I for the subject even if this risk is minor.

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Estimation of the interstitial Oxidative stress: free radicals

These interstitial fluid free radicals of oxidative stress are estimated on scale 0/+ 60, with
reference norms from 0 to +20 (red lines).
The calculation is made by the chronoamperometry method (Cottrell equation)

Help in interpretation:
The oxygen free radicals (H202 and O2-) increased the entropy: Selenium will reduce these
free radicals
The ONOOH. NO and OH- free radicals increased the DNA damages: Manganese will reduce
these free radicals.
This graphic explains the mechanism of the free radicals production, and which substances
are active in their production and prevention.

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Estimation of the interstitial cerebral Neurotransmitters:

These values are an estimation of interstitial fluid cerebral neurotransmitters.
The calculation is made by the chronoamperometry method (Cottrell equation) in a scale 60/+60 with reference norms range from -20 to +20 (red lines).
The validation of this measurement are made by the clinical tests in St Louis hospital, Botkin
hospital 2006 and the study for ADHD children (Dr Caudal France)

Only the EIS system will provides these results

Help in interpretation:
Interstitial cerebral Serotonin:
Decreased => Depression, emotional disorders
Increased=> Insomnia, behaviour disorders
Interstitial cerebral Dopamine
Increased => addiction, hyperactivity, lack of concentration, aggressively
Decreased=> lack of communication, lassitude, lack of vitality
Interstitial cerebral Catecholamines
Increased => memory disorders, stress
Decreased=> lack of concentration, lack of vitality, fatigue
Interstitial cerebral Acetylcholine
Increased => Cranial parasympathetic increased and effects on the cardiac rate
frequency (tachycardia)
Decreased=> Cranial parasympathetic decreased and effects on the cardiac rate
frequency (bradycardia)

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Statistical estimation of some blood biochemical constants values

These values are an estimation of blood venous biochemical constants related to the
algorithms issues from clinical study of Marfino center in 2004 (See the full text in
www.ldteck.com) in a scale -60/+60 with reference norms range from -20 to +20 (red lines)

Help in interpretation

DISCLAIMER! According to the results of the tissues parameters, microcirculation and

inverses problems issues from clinical tests the software propose an statistical estimation of
some blood biochemical constants with a specificity and a sensitivity.
These estimation are not a measurement, but help for regulate more specific and sensitive
laboratory tests. These estimations are not available for a patient under medications.
These values are a screening of blood biochemical constants disorders, if the subject is not
under medications
Triglycerides: depend of the fat mass and depend of pancreatic function
Urea: depend of the proteins concentration and kidney function
Creatinine: depend of muscle and kidney function
Glucose: depend of pancreatic function and /or cell insulino resistance: When the glucose
increase: possibility of microcirculation disorders, cardiovascular, ocular and renal disorders.
Atherogenic Index: Ratio LDL (bad cholesterol) and HDL cholesterol (good
cholesterol).This index is the more important for estimated the cardiovascular consequence
(coronary) than the total cholesterol and/or the DHL cholesterol.

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Davenport Diagram
These values of Davenport diagram are measured in interstitial fluid with the
chronoamperometry method (Cottrell equation) for H+ and HCO3 and by Hassenbach
formula for the PCO2
Three type or acidosis/alkalosis ratios exist:
Metabolic: depends of the level of the bicarbonates: Norms SBE=0. Ligns of bicarbonates in
blue (Bic): if the bicarbonates increased (SBE positive), the result is metabolic alkalosis, if the
bicarbonates decreased (SBE negative), the result is metabolic acidosis

Respiratory: Norms PCO2= 46: if the PCO2 decreased (on the left), the result is respiratory
alkalosis, if the PCO2 decreased (on the right) , the result is respiratory acidosis

Interstitial Fluid Norm=7.33

1
3

This icon allows to access to the 22 divisions of the Diagram

Typical Zones:
Acute Respiratory Acidosis (7 & 8)
Chronic Respiratory Acidosis (5)
Metabolic Alkalosis (3)
Acute Respiratory Alkalosis (18 & 19)
Chronic Respiratory Alkalosis (16)
Metabolic Acidosis (14)

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Help in interpretation of the Davenport Diagram

The EIS davenport Diagram is an adaptation of the original Diagram made by Davenport 50
years ago. Originally, this diagram was made with the data from arterial blood.
It was used in hospital for arterial blood gases results and for the patient under anaesthesia.
The value of arterial blood gases analysis is the diagnosis of renal failure or respiratory
insufficiently.
Therefore, in the medical office, this examination is very rarely utilized.
Because there is are no buffers in interstitial fluid (no carbonic anhydrase from red cells and
very low protein concentrations), the acid base balance depends predominently upon the cells
activity (mitochondria ATP production). Useage of the interstitial values in the Davenport
Diagram will allow relatively early detection of dysfunctions, disorders or diseases and
greatly changes the benefits of using this Diagram.
Our patient databases from clinical trials were examined with the interstitial Davenport
Diagram with the following results:
Patients not undergoing under any drugs:
1. On the left of the diagram: respiratory acidosis:
Cardiovascular disorders or diseases
Diabetes II
Renal disorder
Hyperthyroidism
Inflammation or germs infections
2. On the right down: metabolic acidosis
Cancers
Renal failure
Diabetes I
3. On the right of the diagram: Respiratory alkalosis
Hypothyroidism

These results are not available for making a diagnosis, because they have
very high specificity but not low sensibility.
The benefits of the Davenport Diagram is the therapeutic follow up (see the
folder clinical applications)

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Interstitial Ionograms
These values are measured in interstitial fluid with the chronoamperometry method (Cottrell
equation). (See clinical tests 2004 MARFINO in www.ldteck.com)

Help in interpretation in interstitial ionograms:

The blood ionogram (sample in capillary) is rarely regulated in medical office; the main
indication will be the renal disorders.
The reason will be the extreme variability of the results if there is not renal failure or deep
metabolic acidosis or alkalosis (patients in hospital).
The interstitial fluid ionogram
1. Is more stable because this compartment is stagnant.
2. Is not under the dependence of the dilution (intra and extra cellular) which can change
completely the true results: for example, the hyponatremia of dilution.
So the results of interstitial ionograms should be different from blood ionogram (in particular
the natremia) and are complementary.
Interstitial values interpretation
Phosphates:
Increase: Possibility of: Hypoparathyroidism, Hypovitaminose D, Pancreatitis
Hypomagnesaemia, Diarrhoea, Tetania, Cutaneous affections
Decrease: Hyperparathyroidism, Bone affections, Osteolysis, Hypervitaminose D
Potassium:
Decrease Possibility of: Hyper insulinaemia Hyperthyroidism, Interstitial nephropathy
Hypercorticism associed with hypertension (Hyperaldosteronism)
Increase: Possibility of: Hypocorticoadrenal, hypoaldosteronism Diabetes keto acidosis
Hypoinsulinism Muscular troubles Fibrillation, conduction troubles
Drugs linked with hyper kaliaemia: Diuretic, B-blockers, Inhibitor of Angiotensinogenic
enzyme, Antibiotics, Corticoids, Glucose, insulin or potassium perfusion
Calcium:
Decrease Possibility of: Hypoparathyroidism, Hypovitaminose D, Pancreatitis
Hyperphosphataemia, Hypomagnesaemia, Diarrhoea, Tetania
Lower ventricular contraction Cutaneous affections

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Increase: Hyperparathyroidism, Bone affections, Osteolysis, Constipation, Nauseas

Hypervitaminose D
Magnesium:
Decrease: Possibility of: Intestinal malabsorption, Diarrhoeas, Hyperaldosteronism
Hyperthyroid, Hypoparathyroidism, Pancreatitis
Increase Possibility of: Renal failure Blood volume decreased, Hypothyroid
Hyperparathyroid Hypoaldosteronism Diabetes keto acidosis coma Hepatitis by retention

Chlorine/ Sodium:
Decrease: Possibility of: Extra cellular dehydratation
Increased: lipidaemia Increased triglycerides Increased glycaemia, Water retention, Edema
Increase: Possibility of: Hyperventilation, Hyperaldosteronism
Iron:
Decrease: Anaemia
Increase: Hyperchromatose and hepatic disorders

Estimation of interstitial Hormonal assessment

These values are an estimation of interstitial fluid hormonal assessment related to the values
of endocrine organs in the modeling with a scale -60/+60 with reference norms range from
-20 to +20 (red lines)

Help in interpretation in estimation of interstitial hormonal assessment

The interstitial fluid and the blood hormonal assessment are completely different except
for the TSH measurement. (See clinical test Botkin hospital 2006)
The estimation of interstitial fluid hormonal assessment:
1. Is more stable because this compartment is stagnant.
2. Is the true target of the hormones, the bloodstream is only a way for the distribution of
the hormones into the tissue.
Interpretation of the results requires some physiology knowledge, in particular the
chronobiology and the peak of production of the different hormones.
Cortisol:
With inflammation: The production of cortisol is increased. The production of cortisol
reduces the ACTH production (feedback effect) and DHEA balance in cortico adrenal
production)

27

Without inflammation: The peak is the morning (wake up), decrease until 11am, then increase
until 4pm and then decrease.
Thyroid Hormones
The production of the thyroid is increased if the body temperature is too high and/or if you
need to increase your metabolism (stress, effort, sport)
The production of thyroid hormone reduces the TSH production (feedback effect)
At normal body temperature condition, and without stress or effort:
The peak will be at 11am then decrease or stable related your activity.
Catecholamines
Increase with stress, and the production is related to your activity and lifestyle
Reduced catecholamine are related to the symptom of fatigue.
Sexual hormones
For women, related to their menstruation cycle
The production of oestradiol reduces the FSH production (biofeedback effect)
For the men, the level of testosterone is related to the brain activity. Good news increases the
level of testosterone, and bad news, depression, inflammation reduces the level of testosterone
Insulin
Increases with food intake, in particular carbonic hydrate and sugars.
Decreases if you do not eat.
The level of aldosterone is increased in metabolic acidosis
The level of ADH is increased if there is dehydratation.
The level of PTH hormone is related to the calcemia levels.

Body Composition estimation

The calculation of the body composition is made according to the Bioelectrical Impedance
Analysis (BIA) (62) (63).
The BIA analysis uses a range of frequencies between 5Hz and 200 KHz.

Help in interpretation in the body composition

The BMI is not sufficient for estimations of overweight. The body composition is necessary to
understand and follow up a treatment regime.
The body composition is significant for the follow up of sports (fat mass and muscular mass) ,
diabetes (water retention, fat mass) and obesity (fat mass, water retention).
The intracellular and extra cellular water disorders are necessary for follow up the water and
sodium disorders (water retention or dehydratation) and in the follow up of diabetes,
cardiovascular diseases and cancers.

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Supplementary examinations and diet

The supplementary examinations and the nutrition are presented in the form of printable and
modifiable tables before impression
Supplementary examinations
Depending on the results of the statistical functional risk, a list of supplementary
examinations is proposed for the risk I and II:
Conventional examinations
Laboratory tests
The health care professional will choose the final prescription within the clinical context.

Diet and micro-nutrition

Warning! These recommended or not recommended foods are temporary (4- 6 weeks), they
will be revised to the next examination:
These foods are recommended or not recommended according to an analysis program issue
from the acid-base balance, the main functional risk, the BMI and the body composition.
Warning! The micro nutrition is indicating in particularly vulnerable people such as the
malnourished, alcoholics, cancer sufferers and pregnant women. This list of micro nutriments
is a suggestion of some products according to the analysis of tissue parameters, statistical risk
analysis, Body composition and BMI, the health care professional will choose the final
prescription within the clinical context.

Diets are proposed in the form of foods which are recommended or not recommended
Micro-nutrition
Cooking methods
Regime
Food associations
Diet advices

Nutritional and micro nutrional program Analysis (Venn diagram)

29

30

References Table of acid/alkaline foods.

Table 19.A

31

Table 19.B

32

Table 19.C

33

Therapeutic follow up
To open this window, you must select 2 visits: click twice on the last visit, then once on the
visit that you wish compared and visit 2. The 2 visits will be shown in the window on the
bottom right side of the screen.

Modeling and physiological tissue and microcirculation parameters of the organs comparison
example.

34

Button 1: ESG graphs comparison example (scale 0/100 and 100/-100)

Button 2: Free radicals comparison example (oxidative stress)

35

Button 3: Ionogram and hormones comparison example

Button 4: Biochemistry values and davenport diagram comparison example.

36

Button 5: Hormonal Follow up comparison example (for all the visits of the patient)
This process will be taking some minutes, please wait.

Button 6: Acid base balance and body composition comparison example (follow up for all
the visits of the patient)

37

Button 7: Acid base balance and body composition follow up for all the visits of the patient

Button 8: Statistical functional risks comparison example (follow up for all the visits of the
patient)

38

Time necessary for follow-up treatment visualization:

Functional or alternative medicine:

Auricular acupuncture
somatic acupuncture,
homeopathy
biofeedback
5 minutes
Chiropractic:
Immediately following the treatment

Nutrition, micro nutrition:

Plant therapy
micro nutrition
trace elements
nutrition
6 weeks
Allopathic treatments:

Antibiotics: 3 days
Hypotensive therapies: 3 weeks
Antiagregants: 3 weeks
Anticoagulant: 24 hours
Diuretics: 3 weeks
Antidepressants: IRSS: 45 days
Surgery: 24 hours
Chemotherapy: 1 week

39

Summary
A synthesis of the measurements taken in editorial form:
Estimation of interstitial biochemical values
Statistical Main functional Risk
Statistical Associated functional Risk
General metabolic functions

Summary

Physician notes
You can find this icon in all the windows of the software. You can utilize this window with
the functions cut, copy or paste, or write your commentary. When you click OK, this
information will be automatically reported in the summary and in the status report for printing.

40

Auricular acupuncture: ElectroAuriculoGram (E.A.G)

Warning! According to new conventions, the ElectroAuriculoGram (E.A.G) displays on the
ears points, the values of the modeling. The ear illustrations provided are courtesy of Dr.
Terry Oleson.(USA). The list of points (results analysis points, points related to the symptoms
and tabagism) is a suggestion according to the analysis of tissue and blood parameters,
statistical functional risk analysis, and brain analysis. The health care professional will choose
the points within the clinical context.

Icon: Help to choose the points according to the selected symptoms

Icon: Help to choose the points in the tabagism treatment

Icon: Help to choose the points according to the program analysis.

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Somatic Acupuncture:
Measurements are displayed in graphic form and are classified in several groups:
In the analysis list, Chinese names for the meridians have been retained to specify that they
are bioelectrical points and reflexogenic circuits and not the degree by which the organ
corresponding to the meridian is affected. While you click on the list, you get the resistance
value of each meridian.

The main meridians A meridian must be affected bilaterally (right and left)

The Paradoxal meridians

Can be affected unilaterally

42

Tendinous, muscular meridians

A meridian must be affected bilaterally (right and left)

LO points

43

Therapeutic decision aid in choosing somatic acupuncture points

Warning! This list of somatic acupunctures points is a suggestion according to the analysis
of the meridian measurements; the health care professional will choose the points within the
clinical context

Homeopathy
The design was produced by Dr. Richard Clement.(MD France/USA)
Warning! This list of homeopathic products is a suggestion according to the analysis of tissue
and blood parameters, statistical risk analysis, Body composition and BMI, and brain analysis.
The health care professional will choose the final prescription within the clinical context

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Bio feedback Program: (BFP)

The biofeedback program sends alternatively A.C with intensity 650A and frequencies
between 1000 Hz and 50 KHz on the 22 volumes of ESG.
The biofeedback program provides a regulation of the neurovegetative system (sympathetic
and parasympathetic systems) and acts on the stress which affects various volumes of the
body.
According to the value of each volume the program stimulates or reduces the stress (inversion
of polarity).
Indication of Use of Biofeedback Program
The indications of use the Biofeedback Program depend of the understanding and the
consequence of the stress.
Definition of the stress
In medical terms, stress is the disruption of homeostasis through physical or psychological
stimuli. Stressful stimuli can be mental, physiological, anatomical or physical reactions. The
term 'stress' in this context was coined by Austro-Canadian endocrinologist Hans Selye, who
defined the General Adaptation Syndrome or GAS paradigm in 1936.
General Adaption Syndrome ( 69) (70)
This is a model on stress, researched mainly by Hans Selye[3][4] on rats and other animals. His
research involved exposing animals to unpleasant or harmful stimuli such as injections,
extreme cold and even vivisection.
He found that all animals showed a very similar series of reactions, broken into three stages.
He describes this universal response to the stressors as the General Adaption Syndrome or
GAS in 1936.
Stage one: alarm
When the threat or stressor is identified or realized, the body's stress response is a state of
alarm. During this stage adrenaline will be produced in order to bring about the fight or flight
response. There is also some activation of the HPA axis, producing cortisol.
Stage two: resistance
If the stressor persists, it becomes necessary to attempt some means of coping with the stress.
Although the body begins to try to adapt to the strains or demands of the environment, the
body cannot keep this up indefinitely, so its resources are gradually depleted.
Stage three: exhaustion
In the final stage in the GAS model, all the body's resources are eventually depleted and the
body is unable to maintain normal function. At this point the initial autonomic nervous system
symptoms may reappear (sweating, raised heart rate etc.). If stage three is extended, long term
damage may result as the capacity of glands, especially the adrenal gland, and the immune
system is exhausted and function is impaired resulting in decompensation. The result can
manifest itself in obvious illnesses such as ulcers, depression or even cardiovascular problems,
along with other mental issues.

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Neuro-chemistry and Physiology

The neurochemistry of the general adaptation syndrome is now believed to be well understood,
although much remains to be discovered about how this system interacts with others in the
brain and elsewhere in the body.
The body reacts to stress first by releasing the catecholamine hormones, epinephrine and
norepinephrine, and the glucocorticoid hormones, cortisol and cortisone.
The hypothalamic-pituitary-adrenal axis (HPA) is a major part of the neuroendocrine system,
involving the interactions of the hypothalamus, the pituitary gland, and the adrenal glands.
The HPA axis is believed to play a primary role in the body's reactions to stress by balancing
hormone releases from the adrenaline-producing adrenal medulla, and from the corticosteroidproducing adrenal cortex. Stress can significantly affect many of the body's immune systems,
as can an individual's perceptions of, and reactions to, stress. The term
psychoneuroimmunology is used to describe the interactions between the mental state,
nervous and immune systems, as well as research on the interconnections of these systems.
Actions of cortisol and the catecholamine: (68)
Sugars Metabolism: increase in the production of sugars by the liver: hyperglycaemia and
hyperinsulinism (diabetes).
Proteins Metabolism: increase in the protidic destruction (muscles, skin, bone)
Fat mass Metabolism: inhibit the lipogenesis, raises cholesterol and triglycerides
Water, Calcium and Sodium Metabolism: increase the drainage of water by the kidney, the
retention of salt and the calcium and potassium loss in the urines.
Bone tissue metabolism and growth: inhibition of Growth by action on the cartilage,
antagonism with the vitamin D and probable inhibition of the growth hormone. The stop of
the growth in the child can occur for amounts relatively low.
Action on coagulation: increase the risk of thrombosis.
Action in Brain: Euphoria action, stimulative on the central nervous system and increase the
risk of insomnia.
Bloodstream Action Hypertensive action and hypoxemia
Immunological Action: action anti-inflammatory and anti-allergic agent
In excess cortisol Increase the risk of infections.
Digestive Action: increase the gastric acidity being able to involve an ulcer and decrease the
colon peristaltic action.
Oxidative stress action: Increase the free radicals of oxygen
Common factors of stress
Both negative and positive stressors can lead to stress. Some common categories and
examples of stressors include:

Sensory: pain, bright light

Life events: birth and deaths, marriage, and divorce
Responsibilities: lack of money, unemployment
Work/study: exams, project deadlines
Personal relationships: conflict, deception

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Lifestyle: heavy drinking, insufficient sleep

Early life exposure (e.g. child abuse) can permanently alter an individual's stress
response
Environmental: Lack of control over environmental circumstances, such as food,
housing, health, freedom, or mobility.

One evaluation of the different stresses in people's lives is the Holmes and Rahe stress scale.
Chronic stress
Chronic stress is stress that lasts a long time or occurs frequently. Chronic stress is potentially
damaging. Family problems, a difficult class at school, a schedule that is too busy, or a long
illness can cause chronic stress.
Symptoms of chronic stress are:
eating problems, upset stomach, headache, backache, insomnia, anxiety, depression, or anger.
There are many ways to control chronic stress, including exercise, proper diet, time
management, adequate rest, and relaxing hobbies.
Oxidative stress
Oxidative stress is caused by an imbalance between the production of reactive oxygen and a
biological system's ability to readily detoxify the reactive intermediates or easily repair the
resulting damage. All forms of life maintain a reducing environment within their cells. The
cellular redox environment is preserved by enzymes that maintain the reduced state through a
constant input of metabolic energy. Disturbances in this normal redox state can cause toxic
effects through the production of peroxides and free radicals that damage all components of
the cell, including proteins, lipids, and DNA.
In humans, oxidative stress is involved in many diseases, such as atherosclerosis, Parkinson's
disease and Alzheimer's disease and it may also be important in ageing. However, reactive
oxygen species can be beneficial, as they are used by the immune system as a way to attack
and kill pathogens and as a form of cell signaling.

Protocol of use of the biofeedback program

1. To take a dynamic examination
2. To register a new visit, the patient is in contact with the electrodes face, hands and feet, to
click on icon BFE.
The system sends a variable frequency (between 1000 Hz and 50 KHz) positive or negative
(polarity) according to the value of volume and alternatively on 22 volumes into positive or
negative according to the value of volume in the following sequence:
5 6 7 8 19 20 21 22 11 12 2 4 15 17 1 3 16 18 9 10.
The process lasts approximately 3 minutes
3. To Click twice on visit BFE and then on the icon Control measurement, in order to
note the biofeedback effects.

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4.

If the effects are overall positive, to remake the process 2 times both 6 minutes and
stop the process.

Interpretation and help of the results of alternative medicine

Auricular and somatic puncture
The EIS system provides the possibility of the visualization of your puncture (permanent in
auricular or laser or electro stimulation), in use of the measurement FCM, and follow up.
For this control, the time will be 5 minutes
Biofeedback program
Same possibility of visualization after 3 minutes of sending frequency and or 9 minutes.
Same process, using of the measurement FCM, and follow up.
For this control, the time will be 5 minutes
Homeopathy
Same possibility of visualization after taking the treatment ( not on the skin).
Same process, using of the measurement FCM, and follow up.
For this control, the time will be 5 minutes

Reliability and stability of the results

The results are functional and the reliability is closer to the results of the laboratory tests.
EIS system value of reference was determined from clinical investigations.
The analytical variation reflects the inaccuracy of the method used: one estimates this by
analyzing the test several times.
For EIS system, the follow up of a subject without treatment during 1 year, was made for
more 100 cases, with physiological more modification that the follow up of laboratory tests.
The intra-individual variation is estimated by the repetition of the examination to the same
individual. The clinical investigations at the Botkin hospital, made it possible successively to
record the patients 3 times. No notable modification.
An experiment of Dr. Richard Clement was carried out, by recording 2 patients on 2 different
computers of mark and in 2 different geographical places. No notable modification.
The inter-individual variation estimates by the average values of several individuals and is
influenced by variables such as age and gender.
The EIS system takes in to account age, gender, weight and height in the scale measurement
by applying a mathematical formula with a specific coefficient.
This calibration is carried out automatically by the software after recording of the patients
data.
Its specificity and its sensitivity (See the results of clinical investigations in
www.softmedtechnology.com)

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Factors of variation
The conductivity (and the results of physiologic tissue parameters) can be modified by the
factors of this table 16 and must be included for results interpretation. Some of these factors
are contraindications for the calculation of body composition.

Decrease in conductivity
temperature of the part <
15 C
Tranquilizing
Antidepressant
Barbiturates
Diuretics: Carbonic
Anhydrase
HBP Medications
Statin Drugs
Anticoagulant
Antibiotic
Anti histamine
Morning

Exposure to the light

Menopause
Spa Treatment
Fast
Strict vegetarian
Diarrhoea
Hypolipemiants

Increase in conductivity
Variable factors
temperature of the part > 25 C Contraceptive pill
Radiotherapy
Surgery
Chemotherapy
Substitute hormonal treatment
post or menopausic
Hormonal treatment
Coffee and caffeine
Puberty
Living at high altitude

over 20 cigarettes per day

Seasonal rhythms
Weekly rhythms
Circadian rhythms

Intense physical activity 8

hours before the
examination
Strong alcohol or drugs or
stimulants (amphetamines) 12
hours before the examination
Fever and infections
Vomiting

Pregnancy as from the 5th

month

Acid food or high contribution

protein

Recent emotional shock

Biological rhythms
Race
Posture
Noise

Metal in the body (pins, apart

from the dental prostheses)
Immobilization lying
Menstruation
Lactation

Obesity
Hemorrhages of all kinds

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General principles of Interpretation of the results

Limits of decision:
The interpretation of an EIS scan must not be based only upon a comparison between the
result(s) and the reference values provided by the scan. Interpretation also requires a
definition of physiological limits. On the other hand, physiological limits of decision
fluctuate according to the objectives:
Established diagnosis
Follow-up of the patient
Diseases considered
Possible therapies
Prevalence

So, it is impossible to make the interpretation of the EIS system without the
clinical context
Just like laboratory tests, the interpretation of the EIS requires that the user has medical
knowledge of adequate references and a list of variables which can modify the results. (See
table 17)
The following specific issues need to be understood and respected if one is to properly
interpret the results of an EIS scan:
1. The results obtained by the EIS system should not be used imperatively to confirm nor
deny laboratory tests, the results of imagery devices, or an electrical activity recording device.
Each medical examination or evaluation has its own specificities and results on the same
organ can be different according to the technique used (see table 8 & 9). EIS scanning brings
new elements of a complementary nature such as physiologic tissue and micro circulation
parameters (see table2) as well as the biochemical values of the interstitial fluid. (See table 6)
2. Biochemical values, EIS and Laboratory tests: further comments
Table 1 shows the differences in concentration of the biochemical values for each
compartment.
All the values of interstitial fluid are different from the laboratory tests
There are specifics of this compartment and the interpretation of the results are not the
same that the results of blood or urinary tests. These results are complementary.
(See clinical test in Marfino center 2005 www.softmedtechnology.com)
The pH values are different, (i.e. than arterial blood) because interstitial fluid does not have
the main blood buffering elements (such as Haemoglobin and proteins). The acid base balance
of interstitial fluid is regulated by the cells activity and the electrolytic balance between the
extra and intracellular medium.
The biochemical values are calculated in interstitial fluid .Unlike the bloodstream this
compartment is stagnant.
3. The modeling is a representation of the organs as well as the physiopathology of interstitial
fluid which traverses them. The physiopathology of interstitial fluid will be a direct reflection
of the cellular activity of these organs. EIS does not give information about the physical
structure of organs.

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4. According to the results of the tissues parameters, microcirculation and inverses problems
issues from clinical tests the software propose some statistical possibilities of diseases or
dysfunction with a specificity and a sensitivity. These possibilities are not diagnostic, but
screening or help for regulate more specific and sensitive supplementary examinations.
These possibilities are not available for a patient under medications (drugs or chemotherapy,
radiotherapy, surgery). In this case the statistical functional risk analysis is a follow up of
effects of these therapies.
The strong point of the EIS system is the follow up and the early visualization of the effects of
any therapy.
5. All data about a cells blood, nerves, vessels, lymphatic, muscles, and articulations are
computed by extrapolation.
6. The EIS device provides a lot of results, but for the interpretation of cases, you do not need
all the data. The EIS device is a modeling of the human body and perhaps my point will be
better understood if we make a comparison with another type of modeling, the GPS (Global
Positioning Service).
GPS is a modeling allowing one to find the specific directions about how to get to a specific
destination. To use a GPS, you must first input both the departure address and the destination
address. For the EIS system, the interpretation requires the same information: the departure
address is the clinical context (check up, known pathology, symptoms, any treatment in
progress, antecedents etc.), the destination address is the goal you wish to achieve for the
client and what parameters you need to check in relation to the departure address (clinical
context).

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Manufacturer, Specification developer:

SOFTMED Technology

REF/ DR&I Version 9 01/09/2007

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