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IN NEURODEGENERATIVE
DISEASE
Rafael Rodrigues LIMA2, Ana Maria Rabelo COSTA 3,Renata Duarte DE SOUZA 4 e Walace GOMES-LEALs
RESUMO
Objetivo: e,tudo de,critivo sobre a atuao do proces~'o inflamatrio em doena, neurodegenerativas, com
njse no,doi~'principais' tipos celulares envolvido.v: neutrfilo e macrfago, Mtodo: pesquisa do tema na~'
fontes bibliogrqficas na base de dado,PUBMED/ MEDLINE, Con,5ideraesFinais: existem diversas evidncias
na literatura que mo,tram que, embora o,mecanismos inflamatrios participem dosfenmeno.v de reparao
tecidual, tambm, esto envolvidos em processos de degenerao secundria em doenas agudas e crnicas do
sistema nervoso central.
DESCRITORES:
neutrfilos,
macrfagos,
neurodegenerao
INTRODUO
Inflamao uma resposta de defesa que ocorre
apsdano celular causadopor micrbios, agentesfisicos
(radiao, trauma, queimaduras), qumicos (toxinas,
substncias custicas), necrose tecidual e/ou reaes
imunolgicas1.2,
A reaoinflamatria agudacaractelizasepor uma srie de eventos inter-relacionados, entre os
quais aumento no fluxo sanguneo e permeabilidade
vascularna regio afetada, exsudaode fluido (edema),
dor localizada, migrao e acmulo de leuccitos
inflamatriosdos vasossanguneospara dentro do tecido,
formao de tecido de granulao e reparo teciduall.2,
A resposta inflamatria inclui a participao de
diferentes tipos celulares, tais como neutrfilos,
macrfagos, mastcitos, tinfcitos, plaquetas, clulas
dendrticas,clulasendoteliaise fibroblastos, entre outras,
Durantea infeco, a quimiotaxia um importante evento
e Neuroregenerao
Experimental
da
Paraense de Medicina
V21
(2) abril-junho
2007
29
OBJEnvo
Inflamao
tipos celulares
neutrfilos
macrfagos.
MTODO
Pesquisabibliogrfica na basede dadosPUBMED
(US National Library ofMedicine e lnstitute ofHealth)/
MEDLINE.
e Doenas Neurodegenerativas
no SNC est
incluindo
doenas de Parkinson,
PESQUISA NA LITERATURA
que liberam
fatores neurotxicos
e pr-
residentes, neutrfilos
Clulas
da microglia
so ativadas
que os neutrfilos
so as primeiras
clulas
como clulas
em seres humanos
e em animais
de
experimentao 14,15.
Os mecanismos pelos quais os neutrfilos podem
induzir leso ao tecido neural foram mais investigados em
modelos experimentais de trauma da medula espinhal]4,15.
Aps leso da medula espinhal em ratos, a leso
endotelial parece ser um evento importante subjacente
degenerao neuronal secundria'5,'6. Neutrfilos podem
liberar elastases, espcies reativas derivadas do oxignio
e metaloproteinases,
hemorrgica
rompimento
necrose
por uma
Paraense
de Medicina
V21
(2) abril-.iunho
2007
Macrfagos
CONSIDERAES FINAIS
Existem diversas evidncias na literatura que
mostram que, embora os mecanismos inflamatrios
participem dos fenmenosde reparaotecidual, tambm,
estoenvolvidos em processosde degeneraosecundria
em doenas agudas e crnicas do SNC.
SUMMARY
INFLAMMATION
IN NEURODEGENERATIVE
DISEASE
Rafael Rodrigues I"IMA, Ana Maria Rabelo COSTA, Renata Duarte de SOUZA e Walace GOMES-LEAL
Objective: to describe the performance of the il?flammatol}' process in neurodegenerative disease, with
in the two main involved cellular type.s: neutrophil and macrophage. Method: through bibliographical
the databases PUBMED/ MEDLINE. Final Considerations: diverse evidences in literature exi.s't showing
so the inflammatory mechani,sm,sparticipate of the phenomena qf tecidual repairing, also are involved in
of .s'econdary degeneration in acute and chronic disease of the central nervous system.
KEY
32
WORDS:
neutrophils,
macrophages,
emphasis
.search in
that even
proce.sses
neurodegeneration.
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