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500mg/vial
1g/vial
Dosage Modifications
Renal impairment
Pediatric
500mg/vial
1g/vial
Bacterial Meningitis
Indicated as a single agent therapy for the treatment of bacterial meningitis caused by
Streptococcus pneumoniae (penicillin susceptible isolates), Haemophilus influenzae, and
Neisseria meningitidis
3 months: 40 mg/kg IV q8hr; not to exceed 2 g IV q8hr
Indicated as a single agent therapy for the treatment of complicated skin and skin structure
infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus
pyogenes, Streptococcus agalactiae, viridans group streptococci, Enterococcus faecalis
(vancomycin-susceptible isolates only), Pseudomonas aeruginosa, Escherichia coli, Proteus
mirabilis, Bacteroides fragilis, and Peptostreptococcus species
3 months: 10 mg/kg IV q8hr; not to exceed 500 mg IV q8hr
1% (MetroGel)
topical cream
0.75% (MetroCream)
1% (Noritate)
topical lotion
0.75% (MetroLotion)
Rosacea
Indicated for the topical treatment of inflammatory lesions of rosacea
1%: Apply topically qDay to affected area(s)
0.75%: Apply topically BID to affected area(s)
Administration
Cleanse treated areas prior to application
Apply thin film and rub into skin
Cosmetics may be applied 5 minutes after application
Severe infections
Tonsillitis/pharyngitis
Moxatag: 775 mg PO qDay for 10 days, taken within 1 hour after finishing a meal
Spectrum of action
Severe infections
Spectrum of action
Severe infections
Spectrum of action
Tonsilitis
775 mg (ER tabs) PO qDay for 10 days
Helicobacter Pylori
H pylori infection and active or 1-year history of duodenal ulcer
Triple therapy
1 g PO q12hr for 14 days with lansoprazole (30 mg) and clarithromycin (500 mg)
Dual therapy
1 g PO q8hr for 14 days with lansoprazole (30 mg) in patients intolerant of, or resistant
to, clarithromycin
Anthrax
Infective Endocarditis
Prophylaxis
2 g PO 30-60 min before procedure
Dosing considerations
First trimester: Test to document chlamydial eradication and retest for infection 3 months
after treatment
Administration
Take without regard to meals
Dosing Modifications
Renal impairment: Patients with impaired renal function do not generally require dose reduction
unless impairment is severe; do not administer extended-release product in patients with CrCl
<30 mL/min
GFR <30 mL/min: Should not receive 875 mg (immediate release) or 775 mg (extended release)
GFR 10-30 mL/min: 250-500 mg q12hr, depending on severity of infection
GFR <10 mL/min: 250-500 mg q24hr depending on severity of infection
Hemodialysis patients: 250-500 mg q24hr, depending on severity of infection; patients should
receive additional dose during and at completion of dialysis; do not administer extended-release
product or 875 mg immediate release
Contraindications
Documented hypersensitivity to penicillins, cephalosporins, imipenem
Cautions
Anaphylaxis has been reported rarely but is more likely to occur following parenteral therapy
with penicillins
Clostridium difficile-associated diarrhea (CDAD) has been reported with use of nearly all
antibacterial agents; severity may range from mild diarrhea to fatal colitis; CDAD may occur
over 2 months after discontinuation of therapy; if CDAD is suspected or confirmed, discontinue
immediately and begin appropriate fluid and electrolyte management, protein supplementation,
antibiotic treatment of C difficile, and surgical evaluation
Do not administer in patients with infectious mononucleosis because of risk of development of
erythematous skin rash
Do not administer to patients in the absence of a proven or suspected bacterial infection because
of risk of development of drug-resistant bacteria
Superinfections with bacterial or fungal pathogens may occur during therapy; if suspected,
discontinue immediately and begin appropriate treatment
Adverse Effects
Frequency Not Defined
Anaphylaxis
Anemia
AST/ALT elevation
Mucocutaneous candidiasis
Diarrhea
Headache
Nausea
Vomiting
Rash
Pseudomembranous colitis
Serum sickness-like reactions
Postmarketing Reports
Mucocutaneous candidiasis
Gastrointestinal (eg, black hairy tongue and hemorrhagic/pseudomembranous colitis, which may
occur during or after treatment)
Hypersensitivity reactions (eg, anaphylaxis, serum sicknesslike reactions, erythematous
maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis,
toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity
vasculitis, urticaria)
Moderate increase in AST and/or ALT; hepatic dysfunction (eg, cholestatic jaundice, hepatic
cholestasis and acute cytolytic hepatitis have been reported)
Renal (eg, crystalluria)
Anemia (eg, hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia,
leukopenia, agranulocytosis)
CNS reactions (eg, reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions,
behavioral changes, dizziness)
Tooth discoloration (brown, yellow, or gray staining); may be reduced or eliminated with
brushing or dental cleaning