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My Summary:

The speakers participated in this partnering forum in fact are doing work that are in great match to present ITRI research activities.

1 The first speaker , Jon Cooper from U. Glasgow specializes in rapid

diagnostics using a Surface Acoustic Wave (SAW) platform.

eliminate the need for channels while better control fluid movement and cell

separation in sample preparation and cost-effect diagnostic tests.

This could

NOTE:

believe that if time allows, we should include his technology (SAW) into the 國合計畫 , together with Dr. Veres.

He is very interested in international collaboration.

And I

2 Second speaker is from a UK manufacturing biomedical device Surgical

Innovation to work on minimally-invasive technologies.

works on a number of novel designs to already-in-use products

Their company

3 Third speaker Dr. Pankaj from Uof Edinburgh specializes in mathematical modeling based on microCT scan of bone behavior to predict possible

damage in stress/strain and to assess suitable replacement designs.

modeling can reduce the amount of time and cost required to joint design.

This

4 Fourth speaker: Dr. Dahiya from U Glasgow works on ultrathin biosensors for

robotic use and also for further applications such as in mobile sensors. has a specialty in graphene and inorganic sensors that can be used in 3D.

He

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Event:

2016 年臺灣英國高階醫材研討會暨合作商談會 為強化臺灣醫療產業之國際競爭力,增加國際相關產業交流及合作,結合臺灣亞太區域優勢,創 造出高附加價值產品行銷全球。我們邀請了數家英國新創醫材團隊來臺交流,藉由此活動也將英 國知名大學產學研發體系(U of Glasgow 格拉斯哥大學, U of Edinburgh 愛丁堡大學,劍橋大學) 與國內業界分享。活動規劃如下:

一、活動名稱:

2016 年臺灣英國高階醫材研討會

二、主辦單位:

英國在台辦事處(British Office

協辦單位: 工研院國際中心 三、時間: 2016 3 8 () 09:30~12:00 (研討會) 13:30~16:30 (商談會) 四、地點: 工研院(竹東)中興院區 51 3A 會議室 五、研討會議程:

日期

時間

活動內容

 

09:30-

 

10:00

報到

10:00-

 

10:10

英國在台辦事處代表致詞

10:10-

工研院代表致詞

10:20

王明哲營運長,生醫與醫材研究所

10:20-

專題演講: 臺灣醫材產業發展現況及未來展望 講者: TBD

10:40

3/8

10:40-

演講主題:Novel formats for in vitro diagnostics 講者: Professor Jonathan Cooper, University of Glasgow Vice Principal Innovation & Knowledge Exchange Wolfson Chair of Bioengineering Founder of SAW Dx, Clyde Biosciences, and Mode Dx Ltd

()

11:00

11:00-

演講主題:UK Manufacturing and drive to innovate 講者: Chris Rawnsley, Global Sales Manager of Surgical Innovations Group Plc.

11:20

11:20-

演講主題:Modelling and optimising the behaviour of joint and fracture fixation implants in osteoporotic bone 講者: Dr. Pankaj Pankaj Dean International (South Asia) Deputy Head of the Institute for Bioengineering

11:40

11:45-

演講主題:Robotics in Automation, Bendable electronics

12:00

Dr. Dahiya

(BEST Group at U. of Glasgow)

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背景 : 新創 、 高階醫材 、 奈米技術 疾病診斷 、 歐盟計劃 合作項目 : 代理 、

背景: 新創高階醫材奈米技術 疾病診斷歐盟計劃 合作項目:代理台英產學合作計劃 申請臨床試驗合作(英國已有) 投資 spin-out合作開發

 

背景: 體外檢測 POC 流道模組

背景 : 體外檢測快篩系統 背景 : 心肌細胞治療
背景 : 體外檢測快篩系統 背景 : 心肌細胞治療

背景:體外檢測快篩系統 背景:心肌細胞治療

背景 : 腹腔鏡 、 減重 、 關節鏡 、 高階

背景: 腹腔鏡減重關節鏡高階

醫材

合作項目:代理銷售合作開發

 

背景 : 英國國民保健署 (NHS) 醫療 政策 、 關節鏡 、 植入性骨科技術 合作項目 : 產學合作

背景: 英國國民保健署(NHS)醫療 政策關節鏡植入性骨科技術 合作項目:產學合作新創公司台 英產學合作計劃申請

BEST group, University of Glasgow

背景:E-skin; bendable electornics

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Notes from Speaker Presentation

Speaker 1.

The Regulatory Pathway for Medical Devices in Asia

Three strategies for success

Dr. Min Wang

1. Determine if we are truly working with a medical device, if yes, then take the regulatory pathway

2. Identify the appropriate risk level for your product

3. Implement proper design controls, learn the regulatory tools: be regulatory intelligent

Brief overview of the regulatory bodies in Southeast Asia

A) Taiwan, TFDA, division of medical devices and cosmetics 16 categories of medical devices; 3 risk classes: 1, 2,3

B) China CFDA/cMDE, undergo major changes such that registration and supervision are now focused

C) Japan: Classes I-IV

D) South Korea: Ministry of Food and Drug Safety (MFDS) which also gone major restructuring last year

E) ASEAN : AMDD

F) Asian Harmonization Working Party

Speaker 2: Dr. Paul Lai (Dephoron group) Development in digital health Health , income, education, environment: Commonwealth countries rank among the top 10. Overview of Taiwan Industry: 0.32% world population; 0.7% GDP, 0.48% health expenditure, 1.9% total wealth; produces 3.2% medical products 8 million households consumes 60% GDP; healthcare consumption only 14.5% of total Taiwan; when calculated, 200 billion is paid out-of-pocket 34,000 physicians in Taiwan, and each person visits the clinic 15 times/year The US invested 2 billion for the HGP, but the return is more than 25x; one of the most successful investments. So many initiatives and projects: HGP, HUPO, ENCORE, HCP, HBP, Brain initiative So much data, who will spend the effort to work through these? A recent example: adipokines conects obesity to dementia; Lancet Neurology 2014 Kevin Tracy connects nervous system to the immune system (TNF-a; Set Point) Some initiatives in Taiwan: CRUX healthTech The advantage of clinical consortiums throughout Taiwan

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Speaker 3:

Dr. Jon Cooper

University of Glasgow:

Acoustic Holograms to Shape Microfluidics Flows

Vice Principal for Knowledge Exchange

Rapid diagnosis:

PAST accomplishments

1. LED and origami paper isothermal PCR

2. MODE unit for detecting AFP in colorectal cancer

3. Lab-on-chip microfluidics

Using surface acoustic waves

1. Acoustic:

(10 mm aperture)

voltage, frequency, affect internal friction in water , generation of heat with

collision caused by power-loss

Wafer-

2.

3. Rayleigh waves

4. Created disposable acoustic platform with lithium niobate wafer and disposable sampling point

droplet interface:

reflection, radiative pressure, capillary pressure

A. Applications:

B. Warfarin titration:

C. NHS:

blood lysis1000x enrichment

measure viscosity of blood

chlamydia and gonorrhorea Isothermal amplication to speed up the STI

workflow

D. Atomisation, nebulisation: drug delivery, gene therapy, 1-5uM to enter the lung

Cooperation with Abbott/Alere; Vectura; Illumina; advanced liquid logic (?), Gates foundation

WEBSITE:

Publications (selected):

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Speaker 4.

Surgical Innovations

UK Manufacturing and drive to innovate 講者: Chris Rawnsley, Global Sales Manager of Surgical Innovations

As the only British company that does manufacturing in the UK, there is much government support!!

The long road from initial innovation in the house to the eventual building of manufacturing plant, from little regard to regulatory details to stringent accordance to requirements, all focused on a major product: the liver retractor (moving the liver out of the path of surgery)

Some innovative ideas behind success:

1. Reusable handle, disposable (always fresh) head

2. Decreasing size:

3. Segmented folding :

16mm 3mm

rod to pretzel design

Advanced medical innovation:

visibility of procedure, minimal damage and speedy recovery.

hernia fixation from staples to glue; minimal change and

http://www.surginno.com/

minimal damage and speedy recovery. hernia fixation from staples to glue; minimal change and http://www.surginno.com/ 6

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Speaker 5.

Dr. Pankaj Pankaj

University of Edinburgh

Modeling and optimizing behavior of joints

Medical simulation and modeling will save you much time and pain

1. Bone properties: microCT scan

2. Material properties:

elasticity ; cortical bone data with microCT scan; periosteal and

endosteal

3. Time-dependent properties: prevent orthopedic implant loosening and response to

traumatic event prediction;

linear and nonlinear viscoelasticity

4. Material property: post-elastic : 29Million degree of freedom; the way bone eases however,

is very similar.

Strain and stress.

A. Application:

B. Locking plates:

determine number of wires that are needed to hold joint in place

length, plate d+l’

working strength, bone width, bone density,

bone plate fracture site

C. Joint replacement:

total knee replacement; modular stems, unilateral knee

replacement

5. Boundary conditions:

6. Other research areas

stresses in the pelvis, effect of muscles and ligaments

A. Implantable microsystems for anti-cancer treatment:

O2, pH, temp

B. Industrial biotechnology:

LiFi

RF spectrum relief:

radiotherapy; oxygen/hypoxia;

light for communication

O2, pH, temp B. Industrial biotechnology: LiFi RF spectrum relief: radiotherapy; oxygen/hypoxia; light for communication 7
O2, pH, temp B. Industrial biotechnology: LiFi RF spectrum relief: radiotherapy; oxygen/hypoxia; light for communication 7

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Speaker 6: Dr. Ravinder Dahiya University of Glasgow : Bendable electronics; skin in robotics; prosthetics and medical applications (BEST Group)

1. Ultraflexible, ultrathin, electronics

Focus on grapheme, flexible sensors; bendable chip modeling, nanostructure, 3D prosthetic hands

2. Wearable systems:

Smallest electrobeam pattern of < 3nm

Alignment of 0.46nm

bioelectronics systems

(James Watt Nanofabrication Centre)

3. Robotics in Automation: feedback is essential for machine control POSFET piezoelectronics

a. 3D

b. Organic and inorganic semiconductors: RoboSkin

c. 3D structure: 2D layout build semiconductor layout rebuild into 3D structure (Triangular module)

d. Problem: inorganic semiconductors are only slightly flexible and therefore only large curvatures can be made.

e. Organic semiconductors are tested based on graphene: cheap but does not work well

conformable, with touch, temperature, thermoelectric, memory

as electroconductors; form capacitance sensors.

f. Form printable tactile skin : top down or bottom up approaches have been developed.

g. Possible novel applications in biomedical instruments and self-health management monitoring

have been developed. g. Possible novel applications in biomedical instruments and self-health management monitoring 8
have been developed. g. Possible novel applications in biomedical instruments and self-health management monitoring 8

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